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公开(公告)号：US09187835B2
公开(公告)日：2015-11-17
申请号：US13474599
申请日：2012-05-17
申请人： Thomas A. Albrecht , Ryan J. Gilliam , Bryan Boggs , Kyle Self , Dennis W. Solas , Michael Kostowskyj , Margarete K. Leclerc , Alexander Gorer , Michael Joseph Weiss
发明人： Thomas A. Albrecht , Ryan J. Gilliam , Bryan Boggs , Kyle Self , Dennis W. Solas , Michael Kostowskyj , Margarete K. Leclerc , Alexander Gorer , Michael Joseph Weiss
CPC分类号： C25B3/06 , B01J27/122 , B01J27/132 , C07C17/02 , C07D301/03 , C25B1/00 , C25B1/02 , C25B1/16 , C25B1/18 , C25B1/20 , C25B1/26 , C25B1/46 , C25B3/02 , C25B9/06 , C25B9/08 , C25B11/0489 , Y02E60/366
摘要： There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
摘要翻译： 提供了包括阳极和阴极的电化学电池的方法和系统，其中阳极与将金属离子从较低氧化态转化为较高氧化态的金属离子接触。 较高氧化态的金属离子与氢气，不饱和烃和/或饱和烃反应形成产物。
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公开(公告)号：US20080306285A1
公开(公告)日：2008-12-11
申请号：US12111188
申请日：2008-04-28
申请人： Ron L. Hale , Dennis W. Solas , Kathleen Simis , Amy T. Lu , Peter M. Lloyd
发明人： Ron L. Hale , Dennis W. Solas , Kathleen Simis , Amy T. Lu , Peter M. Lloyd
IPC分类号： C07D311/80 , C07C39/06 , C07J1/00
CPC分类号： C07C69/96 , C07C59/68 , C07D311/80 , C07J1/0051 , C07J41/0072
摘要： Disclosed herein are heat-labile prodrugs, their preparation and uses.
摘要翻译： 本文公开了热不稳定的前药，其制备和用途。
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3.发明授权Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 失效通过吸入途径递送舒马曲坦，呋喃曲坦或纳拉曲坦公开(公告)号：US07014840B2
公开(公告)日：2006-03-21
申请号：US10792239
申请日：2004-03-03
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing sumatriptan, frovatriptan, or naratriptan that are used in inhalation therapy. In a method aspect of the present invention, one of sumatriptan, frovatriptan, or naratriptan is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising sumatriptan, frovatriptan, or naratriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering sumatriptan, frovatriptan, or naratriptan through an inhalation route is provided which comprises: a) a thin coating of a sumatriptan, frovatriptan, or naratriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送抗偏头痛化合物。 具体地说，它涉及用于吸入治疗的含有舒马曲坦，呋喃曲坦或纳拉曲坦的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用舒马普坦，福来曲坦或纳拉曲坦中的一种。 该方法包括：a）加热组合物，其包含舒马曲坦，呋喃曲坦或纳拉曲坦，形成蒸气; 和b）允许蒸气冷却，由此形成少于药物降解产物的5％的凝结气雾剂。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送舒马曲坦，福来曲坦或纳拉曲坦的试剂盒，其包括：a）舒马曲坦，福布曲坦或纳拉曲坦组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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4.发明授权Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 失效通过吸入途径递送舒马曲坦，呋喃曲坦或纳拉曲坦公开(公告)号：US06805854B2
公开(公告)日：2004-10-19
申请号：US10155705
申请日：2002-05-22
IPC分类号： A61K912
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing sumatriptan, frovatriptan, or naratriptan that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of sumatriptan, frovatriptan, or naratriptan. In a method aspect of the present invention, one of sumatriptan, frovatriptan, or naratriptan is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of sumatriptan, frovatriptan, or naratriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering sumatriptan, frovatriptan, or naratriptan through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of sumatriptan, frovatriptan, or naratriptan; and, b) a device that forms a sumatriptan, frovatriptan, or naratriptan aerosol from the composition, for inhalation by the mammal.
摘要翻译： 本发明涉及通过吸入途径递送抗偏头痛化合物。 具体地说，它涉及用于吸入治疗的含有舒马曲坦，呋喃曲坦或纳拉曲坦的气溶胶。 在本发明的组合物方面，气溶胶包含包含至少5重量％的舒马曲坦，呋喃曲坦或纳拉曲坦的颗粒。 在本发明的方法方面，舒马曲坦，福来曲坦或纳拉曲坦中的一种通过吸入途径递送至哺乳动物。 该方法包括：a）加热组合物，其中所述组合物包含至少5重量％的舒马曲坦，福来曲坦或纳拉曲坦，以形成蒸气; 和b）允许蒸气冷却，由此形成包含由哺乳动物吸入的颗粒的冷凝气雾剂。 在本发明的试剂盒方面，提供了一种用于通过吸入途径向哺乳动物递送舒马曲坦，福来曲坦或纳拉曲坦的试剂盒，其包括：a）包含至少5重量％的舒马曲坦，福替普坦或纳拉曲坦的组合物; 和b）由组合物形成舒马曲坦，福布斯坦或奈拉曲坦气溶胶的装置，用于哺乳动物的吸入。
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公开(公告)号：US5889165A
公开(公告)日：1999-03-30
申请号：US444598
申请日：1995-05-19
IPC分类号： B01J19/00 , C07B61/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K17/06 , C07K17/14 , C08F2/46 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G01N21/25 , G01N21/64 , G03F7/00 , G03F7/004 , G03F7/26 , G03F7/38 , G11C13/02 , C07H19/00 , C07H21/02
CPC分类号： G01N21/6452 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K1/062 , C07K17/06 , C07K17/14 , C07K7/06 , C12Q1/6809 , C12Q1/6816 , C12Q1/6837 , C12Q1/6874 , C40B80/00 , G01N21/253 , G01N21/6428 , G03F7/00 , G03F7/0045 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6458 , Y02P20/55 , Y10S435/969 , Y10S435/973 , Y10S436/807 , Y10S436/809
摘要： A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
摘要翻译： 创造大规模化学多样性的综合战略。 使用固相化学，光不稳定保护基团和光刻法来实现光定向空间可寻址并行化学合成。 在一个实施例中使用二进制掩蔽技术。 还公开了反应器系统，可光除保护组和改进的数据收集和处理技术。 还提供了筛选接头分子的技术。
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公开(公告)号：US5032677A
公开(公告)日：1991-07-16
申请号：US118292
申请日：1987-11-06
申请人： Ron L. Hale , Dennis W. Solas
发明人： Ron L. Hale , Dennis W. Solas
IPC分类号： C07D213/79 , C07D213/81 , C07D401/14
CPC分类号： C07D213/79 , C07D213/81 , C07D401/14 , Y10S436/80
摘要： A class of fluorescent rare earth chelates and the ligands upon which they are based whose molecular structure incorporates a plurality of substituted arylpyridine diacid units attached to a central template structure is disclosed. These ligands function as efficient energy transfer groups in fluorescent tagging reagents and tracers. ##STR1##
摘要翻译： 公开了一类荧光稀土螯合物及其所属的配体，其分子结构包含连接至中心模板结构的多个取代的芳基吡啶二酸单元。 这些配体在荧光标记试剂和示踪剂中起到有效的能量转移基团的作用。
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公开(公告)号：US4761481A
公开(公告)日：1988-08-02
申请号：US712774
申请日：1985-03-18
申请人： Ron L. Hale , Dennis W. Solas
发明人： Ron L. Hale , Dennis W. Solas
IPC分类号： C07D213/36 , C07D213/38 , C07D213/55 , C07D213/79 , C07D405/14 , C07D473/08 , C09K11/06 , G01N21/78 , G01N33/533 , C07D213/68 , C07D213/65 , C07D213/73
CPC分类号： C07D213/79 , C07D213/38 , C07D405/14 , C07D473/08 , G01N33/533 , Y10S436/80
摘要： It is disclosed that aryl-substituted 2,6-bis[N,N-di(carboxyalkyl)aminoalkyl] pyridines in which the aryl groups are substituted with one or more electron-releasing groups are an advantageous ligand for forming fluorescent chelates with rare earth metals. The pyridine moieties can be linked to target molecules, especially biologically active target molecules to provide fluorescent tagging for use in fluoroassay techniques. The pyridine moieties are disclosed as tetraacids, as salts and as esters. Preparation processes and precursors including the corresponding aryl-substituted 2,6-dicarboxypyridines as acids, salts and esters, are disclosed as well.
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公开(公告)号：US20120292196A1
公开(公告)日：2012-11-22
申请号：US13474598
申请日：2012-05-17
申请人： Thomas A. Albrecht , Ryan J. Gilliam , Bryan Boggs , Kyle Self , Dennis W. Solas , Michael Kostowskyj , Margarete K. Leclerc , Alexander Gorer , Michael Joseph Weiss
发明人： Thomas A. Albrecht , Ryan J. Gilliam , Bryan Boggs , Kyle Self , Dennis W. Solas , Michael Kostowskyj , Margarete K. Leclerc , Alexander Gorer , Michael Joseph Weiss
IPC分类号： C25B15/00
CPC分类号： C25B3/06 , B01J27/122 , B01J27/132 , C07C17/02 , C07D301/03 , C25B1/00 , C25B1/02 , C25B1/16 , C25B1/18 , C25B1/20 , C25B1/26 , C25B1/46 , C25B3/02 , C25B9/06 , C25B9/08 , C25B11/0489 , Y02E60/366
摘要： There are provided methods and systems for an electrochemical cell including an anode and a cathode where the anode is contacted with a metal ion that converts the metal ion from a lower oxidation state to a higher oxidation state. The metal ion in the higher oxidation state is reacted with hydrogen gas, an unsaturated hydrocarbon, and/or a saturated hydrocarbon to form products.
摘要翻译： 提供了包括阳极和阴极的电化学电池的方法和系统，其中阳极与将金属离子从较低氧化态转化为较高氧化态的金属离子接触。 较高氧化态的金属离子与氢气，不饱和烃和/或饱和烃反应形成产物。
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公开(公告)号：US07923662B2
公开(公告)日：2011-04-12
申请号：US12015893
申请日：2008-01-17
申请人： Ron L. Hale , Mingzu Lei , Hilary N. Pettit , Dennis W. Solas , Soonho Song , Curtis Tom
发明人： Ron L. Hale , Mingzu Lei , Hilary N. Pettit , Dennis W. Solas , Soonho Song , Curtis Tom
CPC分类号： F23Q3/006
摘要： High sparking initiator compositions with a controlled amount of power are disclosed. The initiator compositions comprise a metal containing oxidizing agent, at least one metal reducing agent, and a non-explosive binder. Low voltage igniters that provide bidirectional plumes upon ignition are also disclosed. These igniters have a electrically resistive element positioned across a hole in a support which directs the plume. These igniters and compositions are useful in the actuation of solid fuel heating unit, in particular, sealed heating units.
摘要翻译： 公开了具有受控量功率的高火花引发剂组合物。 引发剂组合物包含含金属的氧化剂，至少一种金属还原剂和非爆炸性粘合剂。 还公开了在点火时提供双向羽流的低电压点火器。 这些点火器具有定位在引导羽流的支撑件中的孔的电阻元件。 这些点火器和组合物在固体燃料加热单元，特别是密封加热单元的致动中是有用的。
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10.发明授权Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 失效通过吸入途径递送舒马曲坦，呋喃曲坦或纳拉曲坦公开(公告)号：US07005122B2
公开(公告)日：2006-02-28
申请号：US10791915
申请日：2004-03-03
CPC分类号： A61K9/007 , A61K9/0073 , A61K9/12 , A61K31/00 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/19 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/27 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/4196 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/437 , A61K31/473 , A61K31/485 , A61K31/49 , A61K31/495 , A61K31/496 , A61K31/4985 , A61K31/501 , A61K31/519 , A61K31/53 , A61K31/551 , A61K31/5517 , A61K47/54 , A61M11/042 , A61M15/06 , A61M2205/8206 , F24V30/00 , Y10S514/923 , Y10S514/958
摘要： The present invention relates to the delivery of anti-migraine compounds through an inhalation route. Specifically, it relates to aerosols containing sumatriptan, frovatriptan, or naratriptan that are used in inhalation therapy. In a method aspect of the present invention, sumatriptan, frovatriptan, or naratriptan is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of sumatriptan, frovatriptan, or naratriptan on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering sumatriptan, frovatriptan, or naratriptan through an inhalation route is provided which comprises: a) a thin coating of a sumatriptan, frovatriptan, or naratriptan composition; and, b) a device for dispending said thin coating as a condensation aerosol.
摘要翻译： 本发明涉及通过吸入途径递送抗偏头痛化合物。 具体地说，它涉及用于吸入治疗的含有舒马曲坦，呋喃曲坦或纳拉曲坦的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用舒马拉坦，福布曲坦或纳拉曲坦。 该方法包括：a）在固体支持物上加热舒马曲坦，呋喃曲坦或纳拉曲坦的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送舒马曲坦，福来曲坦或纳拉曲坦的试剂盒，其包括：a）舒马曲坦，福布曲坦或纳拉曲坦组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。
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