公开(公告)号：US20050000514A1

公开(公告)日：2005-01-06

申请号：US10858447

申请日：2004-06-01

申请人： Vincent Sullivan ,  Ronald Pettis ,  John Mikszta ,  John Dekker ,  Wendy Woodley ,  Anjana Wills ,  Matthew Ferriter

发明人： Vincent Sullivan ,  Ronald Pettis ,  John Mikszta ,  John Dekker ,  Wendy Woodley ,  Anjana Wills ,  Matthew Ferriter

IPC分类号： A61M11/00

CPC分类号： A61M37/0015 ,  A61M11/003 ,  A61M11/008 ,  A61M15/0028 ,  A61M15/0031 ,  A61M15/0033 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2205/075 ,  B05B11/061 ,  B05B11/062

摘要： A method and device for intradermal delivery of a reconstituted powdered medicament. The device includes a chamber, which is in fluid communication with a microdevice, e.g. microabrader or one or more microneedles. A cartridge containing the powdered medicament may be located within said chamber. At least one burstable membrane retains a powdered medicament within the housing. The method involves the steps of positioning the device at a delivery site on the skin of a patient and intradermally administering the medicament by dispensing a diluent from a diluent source an through inlet port to rupture the membranes, reconstitute the powdered medicament and deliver the reconstituted medicament through the microdevice to the dermal region of the skin.

摘要翻译： 用于皮内递送重构粉末状药物的方法和装置。 该装置包括与微型装置例如流体连通的腔室。 微型抛光机或一个或多个微针。 含有粉末状药物的药筒可以位于所述腔室内。 至少一个可爆破膜在壳体内保持粉末状药物。 该方法包括以下步骤：将装置定位在患者皮肤上的递送部位，并通过从稀释剂源通过入口端口分配稀释剂来皮内施用药物，以破裂膜，重构粉末状药物并递送重组的药物 通过微型装置到皮肤的皮肤区域。

公开(公告)号：US20060106346A1

公开(公告)日：2006-05-18

申请号：US11222204

申请日：2005-09-08

申请人： Vincent Sullivan ,  Ge Jiang ,  Matthew Ferriter ,  Kenneth Powell ,  P. Kinsey ,  Carl Sahi ,  John Polidoro

发明人： Vincent Sullivan ,  Ge Jiang ,  Matthew Ferriter ,  Kenneth Powell ,  P. Kinsey ,  Carl Sahi ,  John Polidoro

IPC分类号： A61M37/00 ,  A61M5/20

CPC分类号： A61M5/145 ,  A61M5/1407 ,  A61M5/1409 ,  A61M5/14248 ,  A61M5/14566 ,  A61M5/14586 ,  A61M2005/14256

摘要： A system and method for a patch-like, self-contained multi-component substance infusion device which provides one or more substantially hidden patient needles which can be placed in fluid communication with a fluid reservoir assembly that includes a rigid bladder portion used in conjunction with a non-distensible bladder film, such as a metallized film. The device can be attached to a skin surface via an adhesive contact and a pressurization system provides a pressure to the contents of a fluid reservoir assembly. Improvements to dry powdered formulations for reconstitution for preferred use in the device are also disclosed.