公开(公告)号：US11230732B2

公开(公告)日：2022-01-25

申请号：US16493607

申请日：2018-03-30

申请人： Marcella Chiari ,  Francesco Damin ,  Silvia Galbiati ,  Maurizio Ferrari

发明人： Marcella Chiari ,  Francesco Damin ,  Silvia Galbiati ,  Maurizio Ferrari

IPC分类号： C12Q1/6837 ,  C12Q1/6827

摘要： An assay for detecting gene fragments, including: amplifying gene fragments comprising single-nucleotide polymorphisms (SNPs) to form an initial amplification product; isolating single strand oligonucleotides of interest from the initial amplification product; forming a solution comprising the oligonucleotides of interest and reporter molecules, each reporter molecule having a first oligonucleotide domain configured to hybridize with a complementary oligonucleotide of interest, and a second oligonucleotide domain configured to hybridize with a complementary capture probe; hybridizing, in the solution, the oligonucleotides of interest with the reporter molecules that have complementary first domains; applying the solution to the surface of a microarray including an array of capture probes fixed to a microarray slide; capturing the oligonucleotides of interest on the microarray by hybridizing the second oligonucleotide domains of the reporter molecules with complementary capture probes of the microarray; and detecting the hybridized oligonucleotides of interest captured on the microarray.

公开(公告)号：US08100613B2

公开(公告)日：2012-01-24

申请号：US12003706

申请日：2007-12-31

申请人： Sandro Foletti ,  Maurizio Ferrari ,  Roberto Muselli

发明人： Sandro Foletti ,  Maurizio Ferrari ,  Roberto Muselli

IPC分类号： B23C1/00 ,  B23Q15/013

CPC分类号： B23Q5/045 ,  B23Q2220/006 ,  Y10T83/869 ,  Y10T408/175 ,  Y10T408/566 ,  Y10T409/30448 ,  Y10T409/306832 ,  Y10T409/307672 ,  Y10T409/308176 ,  Y10T409/309296

摘要： Complex workpieces, particularly aeronautical parts made of solid stock presenting a bottom wall and at least one stiffening rib transverse to the bottom wall, are machined using a device having a tool head furnished with a transmission component rotatable about a relative longitudinal axis, and a tool, typically a milling cutter, connected to the transmission component and capable of piercing the transverse rib. The longitudinal axis of the tool is disposed obliquely to the longitudinal axis of the transmission component so that the stiffening rib can be pierced at a point close to the bottom wall of the workpiece. The device also incorporates a feeler mechanism associated with the tool head and designed to engage the bottom wall during the movement of the tool toward the machining location, in such a way that the position of the tool head can be actively controlled and the tool deployed at a selected distance from the bottom wall.

摘要翻译： 复杂的工件，特别是由具有底壁的固体原料制成的航空部件以及横向于底壁的至少一个加强肋，使用具有工具头的装置加工，所述工具头具有可围绕相对纵向轴线旋转的传动部件，以及工具 通常是铣刀，连接到传动部件并且能够刺穿横向肋。 工具的纵向轴线相对于变速部件的纵向轴线倾斜地设置，使得加强肋可以在靠近工件的底壁的点处被刺穿。 该装置还包括与工具头相关联的触发器机构，并被设计成在工具朝向加工位置运动期间接合底壁，使得可以主动地控制工具头的位置并且将工具部署在 距离底壁的选定距离。

公开(公告)号：US07918440B2

公开(公告)日：2011-04-05

申请号：US11443158

申请日：2006-05-31

申请人： Bruno Schiavi ,  Maurizio Ferrari ,  Sandro Foletti

发明人： Bruno Schiavi ,  Maurizio Ferrari ,  Sandro Foletti

IPC分类号： B25B11/00

CPC分类号： B25B11/005 ,  B23Q1/035

摘要： Workpieces of large dimensions, typically body pressings or fuselage panels, are supported and secured for machining by a device capable of movement in a vertical direction and adaptable thus to the particular geometry of the workpiece. The vertical movement is produced by a rod of which the top end carries a head incorporating a pivotable fixture mechanism, equipped with a suction cup connected to a source of negative pressure by way of a suction duct and activated to clamp the work once the head is in position.

摘要翻译： 大尺寸的工件，通常是机身按压或机身面板，由一个能够在垂直方向上移动并能适应工件的特定几何形状的装置来支撑和固定用于机械加工。 垂直运动是由一根杆产生的，其顶端装有一个头部，该头部装有一个可旋转的固定装置，该装置配有一个通过抽吸管连接到负压源的吸盘，一旦头部是 在位。

公开(公告)号：US20090035081A1

公开(公告)日：2009-02-05

申请号：US12003706

申请日：2007-12-31

申请人： Sandro Foletti ,  Maurizio Ferrari ,  Roberto Muselli

发明人： Sandro Foletti ,  Maurizio Ferrari ,  Roberto Muselli

IPC分类号： B23B39/00 ,  B23B49/00 ,  B23B47/00

CPC分类号： B23Q5/045 ,  B23Q2220/006 ,  Y10T83/869 ,  Y10T408/175 ,  Y10T408/566 ,  Y10T409/30448 ,  Y10T409/306832 ,  Y10T409/307672 ,  Y10T409/308176 ,  Y10T409/309296

摘要： Complex workpieces, particularly aeronautical parts made of solid stock presenting a bottom wall and at least one stiffening rib transverse to the bottom wall, are machined using a device having a tool head furnished with a transmission component rotatable about a relative longitudinal axis, and a tool, typically a milling cutter, connected to the transmission component and capable of piercing the transverse rib. The longitudinal axis of the tool is disposed obliquely to the longitudinal axis of the transmission component so that the stiffening rib can be pierced at a point close to the bottom wall of the workpiece. The device also incorporates a feeler mechanism associated with the tool head and designed to engage the bottom wall during the movement of the tool toward the machining location, in such a way that the position of the tool head can be actively controlled and the tool deployed at a selected distance from the bottom wall.

摘要翻译： 复杂的工件，特别是由具有底壁的固体原料制成的航空部件以及横向于底壁的至少一个加强肋，使用具有工具头的装置加工，所述工具头具有可围绕相对纵向轴线旋转的传动部件，以及工具 通常是铣刀，连接到传动部件并且能够刺穿横向肋。 工具的纵向轴线相对于变速部件的纵向轴线倾斜地设置，使得加强肋可以在靠近工件的底壁的点处被刺穿。 该装置还包括与工具头相关联的触发器机构，并被设计成在工具朝向加工位置运动期间接合底壁，使得可以主动地控制工具头的位置并且将工具部署在 距离底壁的选定距离。

公开(公告)号：US20080248185A1

公开(公告)日：2008-10-09

申请号：US11695765

申请日：2007-04-03

申请人： Maurizio Ferrari

发明人： Maurizio Ferrari

IPC分类号： A23L1/035 ,  A23L1/216 ,  A23L1/222 ,  A23L1/224

CPC分类号： A23L33/21 ,  A23L29/10

摘要： Base compositions, methods of manufacturing base compositions and frozen food products including a base composition are described. According to one or more embodiments, a base composition for a frozen food product includes at least one insoluble fiber, at least one soluble fiber, at least one emulsifier and at least one stabilizer. In one or more aspects of the invention, methods are provided for processing the base composition with additional ingredients to provide flavor, sweetness and the like for a variety of frozen food products such as: frozen desserts; ice creams; gelato; and mousse, either confectionary, seafood-type or savory vegetable-type, with desirable organoleptic and stability properties. In one or more embodiments, base compositions and methods described herein are suitable for preparing many types of frozen food products ranging from dairy-type products to those having low-fat, low calorie, fruit flavors and the like.

摘要翻译： 描述了基础组合物，制备基础组合物的方法和包括基础组合物的冷冻食品。 根据一个或多个实施方案，用于冷冻食品的基础组合物包括至少一种不溶性纤维，至少一种可溶性纤维，至少一种乳化剂和至少一种稳定剂。 在本发明的一个或多个方面，提供了用于加工基础组合物与另外成分以提供各种冷冻食品的风味，甜度等的方法，例如：冷冻甜点; 冰淇淋; 冰淇淋 和慕斯，无论是糖果，海鲜类或咸菜植物型，具有理想的感官和稳定性。 在一个或多个实施方案中，本文所述的基础组合物和方法适用于制备许多类型的冷冻食品，其范围从乳制品到具有低脂肪，低热量，水果香料等的那些。

公开(公告)号：US07220088B2

公开(公告)日：2007-05-22

申请号：US11106579

申请日：2005-04-15

申请人： Maurizio Ferrari ,  Sandro Foletti

发明人： Maurizio Ferrari ,  Sandro Foletti

IPC分类号： B23B39/00 ,  B23B35/00 ,  B23C9/00

CPC分类号： B23Q17/2233 ,  B23B2215/04 ,  B23Q11/0046 ,  Y10T408/46 ,  Y10T408/50 ,  Y10T408/5623 ,  Y10T408/56245 ,  Y10T409/30392 ,  Y10T409/304088 ,  Y10T409/30784 ,  Y10T409/308232 ,  Y10T409/309352

摘要： A toolhead for use on a multi-axis machine tool consists of a support assembly equipped with a pivoting spindle designed to accept a removable tool-holder, and centered on a machining axis about which a tool clamped to the tool-holder can be driven in rotation. Also forming part of the toolhead is a depth stop affording an active surface substantially transverse to the machining axis and positionable against a surface of a workpiece. The depth stop is mounted to the support assembly and capable of movement along the machining axis between a first position, distanced from the spindle, and a second position of proximity to the spindle. Transducers incorporated into the toolhead are able to sense the position of the active surface relative to the support assembly, and thus used to control the depth to which the workpiece is penetrated by the tool.

摘要翻译： 在多轴机床上使用的工具头由支撑组件组成，支撑组件配有枢转主轴，设计用于接收可拆卸的工具架，并以加工轴为中心，夹持在刀架上的刀具可围绕该加工轴驱动 回转。 还形成工具头的一部分是提供基本横向于加工轴线并可抵靠工件表面定位的有效表面的深度停止。 深度限位器被安装到支撑组件上，并且能够沿着加工轴线在远离主轴的第一位置与靠近主轴的第二位置之间移动。 结合到工具头中的传感器能​​够感测有源表面相对于支撑组件的位置，并且因此用于控制工件被工具穿透的深度。

公开(公告)号：US07214013B2

公开(公告)日：2007-05-08

申请号：US11106487

申请日：2005-04-15

申请人： Maurizio Ferrari ,  Sandro Foletti

发明人： Maurizio Ferrari ,  Sandro Foletti

IPC分类号： B23C9/00

CPC分类号： B23Q11/0046 ,  Y10T408/98 ,  Y10T409/304032 ,  Y10T409/304088

摘要： A machine tool equipped with a supporting body and at least one tool-holder spindle, rotatable about a respective axis, also has a built-in dust extraction device comprising an extractor hood located in close proximity to the spindle and presenting a suction port positionable near to a machining area, so as to extract chips and dust generated in the course of machining operations; the hood is capable of movement along a direction parallel to the axis of rotation, extended and retracted by the action of respective translating members operating in conjunction with sensors able to read the profile of a workpiece, in such a way that the suction port can be positioned to best advantage.

摘要翻译： 装备有支撑体和至少一个可绕相应轴线旋转的工具架心轴的机床还具有内置的除尘装置，该抽吸装置包括位于主轴附近的抽油烟机，并且具有可位于靠近 到加工区域，以提取在加工操作过程中产生的碎屑和粉尘; 罩能够沿着平行于旋转轴线的方向移动，通过与能够读取工件的轮廓的传感器一起操作的各个平移构件的作用而延伸和缩回，使得吸入口可以 定位到最好的优势。

公开(公告)号：US06655884B2

公开(公告)日：2003-12-02

申请号：US10092632

申请日：2002-03-08

申请人： Maurizio Ferrari ,  Carlo Massari

发明人： Maurizio Ferrari ,  Carlo Massari

IPC分类号： B23C112

CPC分类号： B23Q39/023 ,  B23Q1/012 ,  B23Q5/28 ,  B23Q39/04 ,  Y10T408/385 ,  Y10T409/307728 ,  Y10T409/308288 ,  Y10T409/308344

摘要： The automatic machine tool comprises two parallel longitudinal guides supported by a plurality of columns standing on a base, the guides being slidably engaged with two parallel sliding crossbeams that mount respective machining units. The drive motion for the sliding crossbeams running in the guides is provided by linear electric motors.

公开(公告)号：US06634839B2

公开(公告)日：2003-10-21

申请号：US09946339

申请日：2001-09-06

申请人： Maurizio Ferrari ,  Carlo Massari

发明人： Maurizio Ferrari ,  Carlo Massari

IPC分类号： B23C106

CPC分类号： B23Q1/267 ,  B23Q1/58 ,  B23Q1/70 ,  B23Q5/28 ,  Y10T82/2552 ,  Y10T408/91 ,  Y10T409/307112 ,  Y10T409/307728 ,  Y10T409/309576

摘要： In a machine tool of the type comprising a spindle mounting slide which is driven by a linear electric motor and which runs in a vertical direction in a slideway, the slide comprises two runners designed to engage with corresponding fixed sliding guides integral with the slideway, and two roller pads that slide on corresponding longitudinal sliding surfaces which are also integral with the slideway.

公开(公告)号：US07743526B2

公开(公告)日：2010-06-29

申请号：US12216173

申请日：2008-06-30

申请人： Sandro Foletti ,  Maurizio Ferrari ,  Roberto Muselli

发明人： Sandro Foletti ,  Maurizio Ferrari ,  Roberto Muselli

IPC分类号： G01B3/28 ,  G01B5/18

CPC分类号： G01B3/28 ,  B23Q17/20 ,  B23Q2230/002 ,  G01B5/18

摘要： A device for checking countersink dimensions comprises a measuring head (2) associated with a spindle (3) of a multi-axis process machine (4), and a processing unit operatively associated with the spindle (3) to control spindle movements, the measuring head (2) comprising a contact element (5) that can be inserted into a countersink (101) and a comparator element (7) which, by coming into contact with the countersink and withdrawing, detects the stroke of the contact element (5) inside the countersink (101). A floating member (22) automatically corrects any alignment errors between the contact element (5) and the axis of the countersink (101).

摘要翻译： 用于检查埋头孔尺寸的装置包括与多轴加工机（4）的主轴（3）相关联的测量头（2），以及与主轴（3）可操作地相关联以控制主轴运动的处理单元，测量 头部（2）包括可插入锪孔（101）的接触元件（5）和通过与锪孔接触并抽出的比较器元件（7）来检测接触元件（5）的行程， 在锪孔（101）内。 浮动构件（22）自动校正接触元件（5）和埋头孔（101）的轴线之间的任何对准误差。