公开(公告)号：US20050241023A1

公开(公告)日：2005-10-27

申请号：US10958062

申请日：2004-10-04

Applicant: Mich Hein ,  Andrew Hiatt

Inventor： Mich Hein ,  Andrew Hiatt

IPC: A61K38/00 ,  C07K16/00 ,  C07K16/12 ,  C07K16/44 ,  C12N9/00 ,  C12N9/18 ,  C12N15/82 ,  A01H1/00

CPC classification number: C07K16/00 ,  A61K38/00 ,  C07K16/12 ,  C07K16/1228 ,  C07K16/1275 ,  C07K16/44 ,  C07K2317/13 ,  C07K2319/00 ,  C07K2319/02 ,  C12N9/0002 ,  C12N9/18 ,  C12N15/8242 ,  C12N15/8258

Abstract: The present invention relates to expression and assembly of foreign multimeric proteins—e.g., antibodies—in plants, as well as to transgenic plants that express such proteins. In one of several preferred embodiments, the generation and assembly of functional secretory antibodies in plants is disclosed. The invention also discloses compositions produced by the transgenic plants of the present invention and methods of using same.

Abstract translation: 本发明涉及外源多聚体蛋白质的表达和装配，例如植物中的抗体以及表达这种蛋白质的转基因植物。 在几个优选实施方案中的一个中，公开了植物中功能分泌抗体的产生和组装。 本发明还公开了由本发明的转基因植物产生的组合物及其使用方法。

公开(公告)号：US20070089201A1

公开(公告)日：2007-04-19

申请号：US10536875

申请日：2003-11-28

Applicant: Kristen Briggs ,  Todd Glancy ,  Mich Hein ,  Andrew Hiatt ,  Anton Karnoup ,  W. H. Anderson ,  Dayakar Pareddy ,  Joseph Petolino ,  Beth Rubin-Wilson ,  Doug Taylor ,  Jean Roberts

Inventor： Kristen Briggs ,  Todd Glancy ,  Mich Hein ,  Andrew Hiatt ,  Anton Karnoup ,  W. H. Anderson ,  Dayakar Pareddy ,  Joseph Petolino ,  Beth Rubin-Wilson ,  Doug Taylor ,  Jean Roberts

IPC: A01H5/00 ,  C07K16/18 ,  C12N5/04 ,  C12N15/82

CPC classification number: C12N15/8258 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/087 ,  C07K16/2839 ,  C07K2317/13 ,  C07K2317/41

Abstract: This invention provides for the plant production of immunoglobulins, wherein at least a portion of the glycans attached to the immunoglobulins lack fucose. The invention also provides the constructs; plasmids; vectors; transformed plant cells, transformed plant calli; transformed plant tissues (e.g., leaves, seeds, tubers, etc.); transformed whole plants used to produce such immunoglobulins; methods of producing the immunoglobulins; the immunoglobulins produced by the disclosed methods; and the use of such immunoglobulins.

Abstract translation: 本发明提供免疫球蛋白的植物生产，其中与免疫球蛋白连接的至少一部分聚糖缺乏岩藻糖。 本发明还提供了构建体; 质粒 向量 转化植物细胞，转化植物愈伤组织; 转化的植物组织（例如叶，种子，块茎等）; 转化用于产生这种免疫球蛋白的整个植物; 生产免疫球蛋白的方法; 通过公开的方法产生的免疫球蛋白; 以及使用这种免疫球蛋白。

公开(公告)号：US20080060093A1

公开(公告)日：2008-03-06

申请号：US10590546

申请日：2005-02-23

Applicant: Helge Zieler ,  James Jin ,  Jennifer Mach ,  Gary Rudgers ,  Daphne Preuss ,  Mich Hein ,  Gregory Copenhaver ,  Kevin Keith

Inventor： Helge Zieler ,  James Jin ,  Jennifer Mach ,  Gary Rudgers ,  Daphne Preuss ,  Mich Hein ,  Gregory Copenhaver ,  Kevin Keith

IPC: A01H1/00 ,  A01H5/00 ,  C07K14/00 ,  C12N15/64 ,  C12N9/00

CPC classification number: C12N15/82

Abstract: The invention is generally related to methods of generating plants transformed with novel autonomous mini-chromosomes. Mini-chromosomes with novel compositions and structures are used to transform plants cells which are in turn used to generate the plant. Methods for generating the plant include methods for delivering the mini-chromosome into plant cell to transform the cell, methods for selecting the transformed cell, and methods for isolating plants transformed with the mini-chromosome. Plants generated in the present invention contain novel genes introduced into their genome by integration into existing chromosomes.

Abstract translation: 本发明通常涉及用新型自主小型染色体转化的植物的方法。 具有新组合物和结构的微型染色体用于转化依次用于产生植物的植物细胞。 用于产生植物的方法包括将微型染色体递送到植物细胞以转化细胞的方法，用于选择转化细胞的方法，以及分离用微型染色体转化的植物的方法。 本发明产生的植物含有通过整合入现有染色体而引入其基因组的新基因。

公开(公告)号：US20060105396A1

公开(公告)日：2006-05-18

申请号：US11324947

申请日：2006-01-04

Applicant: Andrew Hiatt ,  Mich Hein ,  John Fitchen

Inventor： Andrew Hiatt ,  Mich Hein ,  John Fitchen

IPC: G01N33/53 ,  C07K16/46

CPC classification number: A61K51/10 ,  A61K39/395 ,  C07K16/00 ,  C07K2317/77 ,  Y10S530/81

Abstract: Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having β-sheet character, each of the domains being separated by domains lacking β-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.