-
公开(公告)号：US20060183695A1
公开(公告)日：2006-08-17
申请号：US11405734
申请日：2006-04-17
申请人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K38/04 , A61K31/502
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
-
公开(公告)号：US20060178316A1
公开(公告)日：2006-08-10
申请号：US11406023
申请日：2006-04-17
申请人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
-
公开(公告)号：US20060178317A1
公开(公告)日：2006-08-10
申请号：US11406484
申请日：2006-04-17
申请人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Stephen Klaus , Al Lin , Thomas Neff , Qingjian Wang , Volkmar Guenzler-Pukall , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K38/04 , A61K31/4745
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.
-
公开(公告)号：US20060258702A1
公开(公告)日：2006-11-16
申请号：US11495118
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/47
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
-
公开(公告)号：US20060270699A1
公开(公告)日：2006-11-30
申请号：US11494978
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/4745
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
-
公开(公告)号：US20060258660A1
公开(公告)日：2006-11-16
申请号：US11495036
申请日：2006-07-28
申请人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
发明人： Volkmar Guenzler-Pukall , Thomas Neff , Qingjian Wang , Michael Arend , Lee Flippin , Alex Melekhov
IPC分类号： A61K31/502
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
-
公开(公告)号：US20050020487A1
公开(公告)日：2005-01-27
申请号：US10861590
申请日：2004-06-03
申请人： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
发明人： Stephen Klaus , Christopher Molineaux , Thomas Neff , Volkmar Guenzler-Pukall , Ingrid Langsetmo Parobok , Todd Seeley , Robert Stephenson
IPC分类号： A61K31/00 , A61K31/165 , A61K31/395 , A61P7/06 , A61K38/16
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及用于治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
-
公开(公告)号：US20050214294A1
公开(公告)日：2005-09-29
申请号：US11057323
申请日：2005-02-11
申请人： Allan Flyvbjerg , Guangjie Guo , David Liu , Thomas Neff , Noelynn Oliver , William Usinger , Qingjian Wang
发明人： Allan Flyvbjerg , Guangjie Guo , David Liu , Thomas Neff , Noelynn Oliver , William Usinger , Qingjian Wang
IPC分类号： A61K31/00 , A61K38/00 , A61K38/55 , A61K39/395 , C07K16/22
CPC分类号： A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
摘要翻译： 本发明涉及用于治疗糖尿病肾病的特异性早期方面和晚期方面的方法和化合物。 还提供了用于治疗与早期和晚期糖尿病肾病相关的各种生理特征的方法和化合物。
-
公开(公告)号：US20050271670A1
公开(公告)日：2005-12-08
申请号：US11119309
申请日：2005-04-28
申请人： Suzanne Spong , Thomas Neff , Stephen Klaus
发明人： Suzanne Spong , Thomas Neff , Stephen Klaus
IPC分类号： A61K39/395 , A61K45/00 , A61K48/00 , C07K14/71 , C07K16/22 , C12Q1/68 , G01N33/574
CPC分类号： A61K39/395 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K14/71 , C07K16/22 , G01N33/57438 , G01N2333/475
摘要： The present invention provides methods for reducing tumor survival, expansion, and metastasis. In particular, the invention provides methods for reducing pancreatic tumor survival, expansion, and metastasis. The invention also provides agents for use in the methods, particularly agents that reduce the level or activity of connective tissue growth factor (CTGF), and methods for identifying such agents.
摘要翻译： 本发明提供了减少肿瘤存活，扩张和转移的方法。 特别地，本发明提供了减少胰腺肿瘤存活，扩张和转移的方法。 本发明还提供用于该方法的试剂，特别是降低结缔组织生长因子（CTGF）的水平或活性的试剂以及用于鉴定此类试剂的方法。
-
公开(公告)号：US20060276477A1
公开(公告)日：2006-12-07
申请号：US11448326
申请日：2006-06-06
申请人： Stephen Klaus , Thomas Neff
发明人： Stephen Klaus , Thomas Neff
IPC分类号： A61K31/502 , A61K31/4745 , A61K31/4704
CPC分类号： A61K45/06 , A61K31/00 , A61K31/17 , A61K31/4365 , A61K31/44 , A61K31/47 , A61K31/4704 , A61K31/4725 , A61K31/473 , A61K31/4745 , A61K31/496 , A61K31/502 , A61K33/26 , A61K38/1816 , A61K2300/00
摘要： The present invention relates to improved methods for treating anemia. Methods and compounds useful for treating anemia, wherein the anemia treatment is associated with a lower risk of thrombosis or hypertension compared to that observed with rhEPO therapy, are provided.
摘要翻译： 本发明涉及治疗贫血的改进方法。 提供了用于治疗贫血的方法和化合物，其中与用rhEPO治疗观察到的相比，贫血治疗与血栓形成或高血压的风险相关。
-
-
-
-
-
-
-
-
-
搜索结果
32 条记录 (耗时 0.035 秒)
