公开(公告)号：US20060178317A1

公开(公告)日：2006-08-10

申请号：US11406484

申请日：2006-04-17

申请人： Stephen Klaus ,  Al Lin ,  Thomas Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

发明人： Stephen Klaus ,  Al Lin ,  Thomas Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

IPC分类号： A61K38/04 ,  A61K31/4745

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.

公开(公告)号：US20060183695A1

公开(公告)日：2006-08-17

申请号：US11405734

申请日：2006-04-17

申请人： Stephen Klaus ,  Al Lin ,  Thomas Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

发明人： Stephen Klaus ,  Al Lin ,  Thomas Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

IPC分类号： A61K38/04 ,  A61K31/502

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.

公开(公告)号：US20060178316A1

公开(公告)日：2006-08-10

申请号：US11406023

申请日：2006-04-17

申请人： Stephen Klaus ,  Al Lin ,  Thomas Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

发明人： Stephen Klaus ,  Al Lin ,  Thomas Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

IPC分类号： A61K31/47 ,  A61K38/04

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo. Methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included. Compounds for use in these methods are provided, as are methods of identifying such compounds.

公开(公告)号：US20060258702A1

公开(公告)日：2006-11-16

申请号：US11495118

申请日：2006-07-28

申请人： Volkmar Guenzler-Pukall ,  Thomas Neff ,  Qingjian Wang ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

发明人： Volkmar Guenzler-Pukall ,  Thomas Neff ,  Qingjian Wang ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

IPC分类号： A61K31/47

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：US20060258660A1

公开(公告)日：2006-11-16

申请号：US11495036

申请日：2006-07-28

申请人： Volkmar Guenzler-Pukall ,  Thomas Neff ,  Qingjian Wang ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

发明人： Volkmar Guenzler-Pukall ,  Thomas Neff ,  Qingjian Wang ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

IPC分类号： A61K31/502

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：US20060270699A1

公开(公告)日：2006-11-30

申请号：US11494978

申请日：2006-07-28

申请人： Volkmar Guenzler-Pukall ,  Thomas Neff ,  Qingjian Wang ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

发明人： Volkmar Guenzler-Pukall ,  Thomas Neff ,  Qingjian Wang ,  Michael Arend ,  Lee Flippin ,  Alex Melekhov

IPC分类号： A61K31/4745

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：US20150080425A1

公开(公告)日：2015-03-19

申请号：US14332814

申请日：2014-07-16

申请人： STEPHEN J. KLAUS ,  Al Y. Lin ,  Thomas B. Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Lee A. Flippin ,  Michael P. Arend ,  Alex Melekhov

发明人： STEPHEN J. KLAUS ,  Al Y. Lin ,  Thomas B. Neff ,  Qingjian Wang ,  Volkmar Guenzler-Pukall ,  Lee A. Flippin ,  Michael P. Arend ,  Alex Melekhov

IPC分类号： A61K31/4745

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention provides methods for treating anemia in a subject having kidney failure by administering a compound that inhibits hypoxia-inducible factor (HIF) prolyl hydroxylase.

摘要翻译： 本发明提供了通过施用抑制缺氧诱导因子（HIF）脯氨酰羟化酶的化合物来治疗患有肾衰竭的受试者的贫血的方法。

公开(公告)号：US20130245037A1

公开(公告)日：2013-09-19

申请号：US13897207

申请日：2013-05-17

申请人： Volkmar Guenzler-Pukall ,  Thomas B. Neff ,  Qingjian Wang ,  Michael P. Arend ,  Lee A. Flippin ,  Alex Melekhov

发明人： Volkmar Guenzler-Pukall ,  Thomas B. Neff ,  Qingjian Wang ,  Michael P. Arend ,  Lee A. Flippin ,  Alex Melekhov

IPC分类号： A61K31/496 ,  A61K31/472 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/44 ,  A61K31/4375 ,  A61K31/17

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

摘要翻译： 本发明涉及稳定缺氧诱导因子（HIF）的α亚基的方法。 本发明还涉及预防，预处理或治疗与HIF相关的病症（包括缺血和缺氧病症）的方法。 还提供了用于这些方法的化合物。

公开(公告)号：US08466172B2

公开(公告)日：2013-06-18

申请号：US12928119

申请日：2010-12-02

申请人： Volkmar Guenzler-Pukall ,  Thomas B. Neff ,  Qingjian Wang ,  Michael P. Arend ,  Lee A. Flippin ,  Alex Melekhov

发明人： Volkmar Guenzler-Pukall ,  Thomas B. Neff ,  Qingjian Wang ,  Michael P. Arend ,  Lee A. Flippin ,  Alex Melekhov

IPC分类号： A01N43/42 ,  A01N43/40 ,  A61K31/47 ,  A61K31/44 ,  C07D217/00

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

公开(公告)号：US20110166145A1

公开(公告)日：2011-07-07

申请号：US12928119

申请日：2010-12-02

申请人： Volkmar Guenzler-Pukall ,  Thomas B. Neff ,  Qingjian Wang ,  Michael P. Arend ,  Lee A. Flippin ,  Alex Melekhov

发明人： Volkmar Guenzler-Pukall ,  Thomas B. Neff ,  Qingjian Wang ,  Michael P. Arend ,  Lee A. Flippin ,  Alex Melekhov

IPC分类号： A61K31/502 ,  A61K31/44 ,  A61K31/47 ,  A61K31/437 ,  A61P9/10

CPC分类号： A61K31/4745 ,  A61K31/00 ,  A61K31/17 ,  A61K31/4375 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/472 ,  A61K31/4738 ,  A61K31/496 ,  A61K31/63 ,  A61K38/1709 ,  C07K14/4702 ,  C07K14/505 ,  G01N33/746

摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.

摘要翻译： 本发明涉及稳定缺氧诱导因子（HIF）的α亚基的方法。 本发明还涉及预防，预处理或治疗与HIF相关的病症（包括缺血和缺氧病症）的方法。 还提供了用于这些方法的化合物。