公开(公告)号：US5249234A

公开(公告)日：1993-09-28

申请号：US851902

申请日：1992-03-16

申请人： Michael J. Butler

发明人： Michael J. Butler

IPC分类号： H04R25/02

CPC分类号： H04R25/00 ,  H04R2460/17 ,  H04R25/654

摘要： A cover for BTE (behind-the-ear) hearing aids includes a hollow latex body configured similar to, but slightly smaller than, an arcuate BTE hearing aid. The cover possesses a larger quadrilateral closed end and a smaller open end. Opposite arcuate planar sidewalls are connected by a convexly curved top wall and a concavely curved bottom wall. The quadrilateral closed end extends transversely between the sidewalls and the top and bottom walls. The sidewalls and top and bottom walls taper and merge smoothly at the open end to form a circular opening. The cover is formed by dipping a complimentary shaped former into a liquid latex mixture, curing the latex to form a solid cover, and removing the cover from the former. In use, prongs of an expander tool are inserted into the open end of the cover, the prongs are then moved apart to mechanically stretch the cover, the BTE hearing aid is then inserted into the open end of the cover, and the cover is relaxed and allowed to conform closely to the outer surface of the hearing aid, preventing damage by moisture and other contaminants.

摘要翻译： 用于BTE（耳后）助听器的护罩包括一个中空胶乳体，其被配置为类似但略小于弧形BTE助听器。 该盖具有较大的四边形封闭端和较小的开口端。 相对的弧形平面侧壁通过凸形弯曲的顶壁和凹入弯曲的底壁连接。 四边形封闭端横向延伸在侧壁和顶壁和底壁之间。 侧壁和顶壁和底壁在开口端平滑并且平滑地合并以形成圆形开口。 通过将互补成形的成型器浸渍到液体胶乳混合物中，固化胶乳以形成固体覆盖物并从前者去除盖子来形成盖子。 在使用中，将扩展器工具的插脚插入盖的开口端，然后将插脚移开以机械地拉伸盖子，然后将BTE助听器插入盖的开口端，并且盖子被放松 并允许与助听器的外表面紧密配合，防止水分和其他污染物的损伤。

公开(公告)号：US5217055A

公开(公告)日：1993-06-08

申请号：US876742

申请日：1992-04-27

申请人： Michael J. Butler

发明人： Michael J. Butler

IPC分类号： B25H1/02 ,  B27C1/02 ,  B27C1/14

CPC分类号： B25H1/02 ,  B27C1/02 ,  B27C1/14 ,  Y10T83/8763

摘要： A table with means for installation of an electric planer therein so that the planer cutting blades engage a workpiece placed upon the table. An adjustable guide fence is also provided with the table for guiding workpieces over the cutting blades of the planer.

摘要翻译： 具有用于在其中安装电动刨床的装置的工作台，使得平面切割刀片与放置在工作台上的工件接合。 还有一个可调节的导向栅栏还设置有用于在刨床的切割刀片上引导工件的工作台。

公开(公告)号：US6127144A

公开(公告)日：2000-10-03

申请号：US951742

申请日：1997-10-16

申请人： Daniel Bartfeld ,  Michael J. Butler ,  Dany Hadary ,  David L. Jenish ,  Timothy J. Krieger ,  Lawrence T. Malek ,  Gisela Soostmeyer ,  Eva Walczyk ,  Phyllis Krygsman ,  Sheila Garven

发明人： Daniel Bartfeld ,  Michael J. Butler ,  Dany Hadary ,  David L. Jenish ,  Timothy J. Krieger ,  Lawrence T. Malek ,  Gisela Soostmeyer ,  Eva Walczyk ,  Phyllis Krygsman ,  Sheila Garven

IPC分类号： C12N9/52 ,  C12P21/06 ,  A61K38/06 ,  C12N1/12 ,  C12N9/48

CPC分类号： C12N9/52 ,  C07K2319/02

摘要： An aminopeptidase inhibitor is used when expressing heterologous protein in a bacterial host, such as Streptomyces. Use of such an inhibitor inhibits degradation of the heterologous protein by aminopeptidases. Inhibitors are designed based upon the mechanism and substrate specificity of the target protease and expressed protein.

摘要翻译： 当在细菌宿主例如链霉菌中表达异源蛋白质时，使用氨肽酶抑制剂。 使用这种抑制剂抑制氨基肽酶对异源蛋白质的降解。 基于靶蛋白酶和表达蛋白质的机制和底物特异性设计抑制剂。

公开(公告)号：US5616485A

公开(公告)日：1997-04-01

申请号：US173508

申请日：1993-12-23

申请人： Dany Hadary ,  Daniel Bartfeld ,  Michael J. Butler ,  David Jenish ,  Timothy Krieger ,  Lawrence T. Malek ,  Gisela Soostmeyer ,  Eva Walcyzk

发明人： Dany Hadary ,  Daniel Bartfeld ,  Michael J. Butler ,  David Jenish ,  Timothy Krieger ,  Lawrence T. Malek ,  Gisela Soostmeyer ,  Eva Walcyzk

IPC分类号： C07K14/475 ,  C07K14/505 ,  C07K14/53 ,  C07K14/535 ,  C07K14/54 ,  C12N9/48 ,  C12N9/52 ,  C12N15/57 ,  C12N15/62 ,  C12N15/76 ,  C12N15/31

CPC分类号： C12N15/76 ,  C07K14/475 ,  C07K14/505 ,  C07K14/53 ,  C07K14/535 ,  C07K14/5418 ,  C12N15/62 ,  C12N15/625 ,  C12N9/48 ,  C12N9/52 ,  C07K2319/00 ,  C07K2319/02

摘要： A family of proteases endogenous to Streptomyces cells degrade heterologous proteins secreted from Streptomyces host cells. The previously unidentified proteases include (1) tripeptidyl aminopeptidase--Streptomyces ("Tap"), (2) a Streptomyces protease ("Ssp") which displayed significant amino acid sequence homology to Subtilisin BPN' and showed an ability to remove tripeprides from the amino termini of proteins and peptides, and (3) other proteases derived from Streptomyces which degraded certain substrates under certain conditions. Degradation was alleviated by selective inhibition of secreted proteases or by using hosts with impaired capabilities to produce proteases. An irreversible inhibitor was designed based upon the mechanism and substrate specificity of the target protease. Hosts secreting high amounts of proteases were selected. Impaired hosts were produced by deleting or altering the nucleotide sequence for the proteases.

摘要翻译： 链霉菌细胞内源的蛋白酶家族降解从链霉菌宿主细胞分泌的异源蛋白质。 以前不明确的蛋白酶包括（1）三肽基氨基肽酶 - 链霉菌（“Tap”），（2）与枯草杆菌蛋白酶BPN'显示显着氨基酸序列同源性的链霉菌蛋白酶（“Ssp”），并且显示出从氨基 蛋白质和肽的末端，和（3）衍生自链霉菌的其它蛋白酶，其在某些条件下降解某些底物。 通过选择性抑制分泌的蛋白酶或通过使用能力下降的宿主产生蛋白酶来减轻降解。 基于靶蛋白酶的机制和底物特异性设计不可逆抑制剂。 选择分泌大量蛋白酶的宿主。 通过缺失或改变蛋白酶的核苷酸序列产生受损宿主。

公开(公告)号：US06398562B1

公开(公告)日：2002-06-04

申请号：US09398984

申请日：1999-09-17

申请人： Michael J. Butler ,  Thomas E. Conn ,  David M. Liu ,  Norman A. Parris ,  Michael Reidy ,  Pravin L. Soni

发明人： Michael J. Butler ,  Thomas E. Conn ,  David M. Liu ,  Norman A. Parris ,  Michael Reidy ,  Pravin L. Soni

IPC分类号： H01R458

CPC分类号： A61B5/1486 ,  A61B5/04087 ,  A61B5/14514 ,  A61B5/1468 ,  A61B2562/0215 ,  A61B2562/0217 ,  Y10S439/909

摘要： Devices and methods are described for improving the contact of a conductive material, for example, a hydrogel, with a sensor, for example an electrode, by means of using mechanical force to apply the conductive material to the sensor before use of the conductive material and sensor in a sampling device. The device and methods of the present invention improve the sensor response characteristics in transdermal sampling devices placed in operative contact with a skin or mucosal surface of a biological system to obtain a chemical signal associated with an analyte of interest.

摘要翻译： 描述了用于改善导电材料（例如水凝胶）与传感器（例如电极）的接触的装置和方法，借助于使用机械力将导电材料施加到传感器之前，在使用导电材料之前， 传感器在采样设备中。 本发明的装置和方法改善放置在与生物系统的皮肤或粘膜表面有效接触的透皮采样装置中的传感器响应特性，以获得与感兴趣的分析物相关的化学信号。

公开(公告)号：US5856166A

公开(公告)日：1999-01-05

申请号：US265310

申请日：1994-06-24

申请人： Daniel Bartfeld ,  Michael J. Butler ,  Dany Hadary ,  David L. Jenish ,  Timothy J. Krieger ,  Lawrence T. Malek ,  Gisela Soostmeyer ,  Eva Walczyk ,  Phyllis Krygsman ,  Sheila Garven

发明人： Daniel Bartfeld ,  Michael J. Butler ,  Dany Hadary ,  David L. Jenish ,  Timothy J. Krieger ,  Lawrence T. Malek ,  Gisela Soostmeyer ,  Eva Walczyk ,  Phyllis Krygsman ,  Sheila Garven

IPC分类号： C07K14/475 ,  C07K14/505 ,  C07K14/53 ,  C07K14/535 ,  C07K14/54 ,  C12N9/48 ,  C12N9/52 ,  C12N15/57 ,  C12N15/62 ,  C12N15/76 ,  C12N1/20

CPC分类号： C12N15/76 ,  C07K14/475 ,  C07K14/505 ,  C07K14/53 ,  C07K14/535 ,  C07K14/5418 ,  C12N15/62 ,  C12N15/625 ,  C12N9/48 ,  C12N9/52 ,  C07K2319/00 ,  C07K2319/02

摘要： A family of proteases endogenous to Streptomyces cells degrades heterologous proteins secreted from Streptomyces host cells. The previously unidentified proteases include (1) tripeptidyl aminopeptidase--Streptomyces ("Tap"), (2) a Streptomyces protease ("Ssp") which displayed significant amino acid sequence homology to Subtilisin BPN' and showed an ability to remove tripeptides from the amino termini of proteins and peptides, and (3) other proteases derived from Streptomyces which degraded certain substrates under certain conditions. Degradation was alleviated by selective inhibition of secreted proteases or by using hosts with impaired capabilities to produce proteases. An irreversible inhibitor was designed based upon the mechanism and substrate specificity of the target protease. Hosts secreting high amounts of proteases were selected. Impaired hosts were produced by deleting or altering the nucleotide sequence for the proteases.

摘要翻译： 链霉菌细胞内源的蛋白酶家族降解从链霉菌宿主细胞分泌的异源蛋白质。 以前不明确的蛋白酶包括（1）三肽基氨基肽酶 - 链霉菌（“Tap”），（2）与枯草杆菌蛋白酶BPN'显示显着的氨基酸序列同源性的链霉菌蛋白酶（“Ssp”），并显示出从氨基 蛋白质和肽的末端，和（3）衍生自链霉菌的其它蛋白酶，其在某些条件下降解某些底物。 通过选择性抑制分泌的蛋白酶或通过使用能力下降的宿主产生蛋白酶来减轻降解。 基于靶蛋白酶的机制和底物特异性设计不可逆抑制剂。 选择分泌大量蛋白酶的宿主。 通过缺失或改变蛋白酶的核苷酸序列产生受损宿主。

公开(公告)号：USD305926S

公开(公告)日：1990-02-06

申请号：US908530

申请日：1986-09-17

申请人： Michael J. Butler

设计人： Michael J. Butler