公开(公告)号：US20130072447A1

公开(公告)日：2013-03-21

申请号：US13471083

申请日：2012-05-14

申请人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick J. Sinko ,  Tamara Minko ,  Gregory C. Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Hee Park ,  Bo Qiu ,  Pankaj Paranjpe

发明人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick J. Sinko ,  Tamara Minko ,  Gregory C. Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Hee Park ,  Bo Qiu ,  Pankaj Paranjpe

IPC分类号： A61K47/48 ,  A61K38/08 ,  A61K47/34

CPC分类号： A61K38/08 ,  A61K47/60 ,  A61K47/62 ,  A61K47/665 ,  B82Y5/00

摘要： The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

摘要翻译： 本发明涉及通过施用以下缀合物之一将治疗剂或诊断剂从一个身体隔室递送至一个或多个其它身体隔室的药物组合物和方法：具有多个官能团的聚合物，其中至少一个共价结合 至少一种与治疗剂或诊断剂共价结合的细胞摄取促进剂; 或与其结合的聚合物和至少一种细胞摄取促进剂; 所述聚合物还包含多个官能团，其中至少一个与治疗剂或诊断剂共价结合。

公开(公告)号：US07740882B2

公开(公告)日：2010-06-22

申请号：US11170652

申请日：2005-06-29

申请人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick J. Sinko ,  Tamara Minko ,  Gregory C. Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Hee Park ,  Bo Qiu ,  Pankaj Paranjpe

发明人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick J. Sinko ,  Tamara Minko ,  Gregory C. Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Hee Park ,  Bo Qiu ,  Pankaj Paranjpe

IPC分类号： A61K9/20 ,  A61K38/04 ,  A61K38/00 ,  A61K51/00

CPC分类号： A61K47/48346 ,  A61K38/08 ,  A61K47/60 ,  A61K47/62 ,  A61K47/665 ,  B82Y5/00

摘要： The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

摘要翻译： 本发明涉及通过施用以下缀合物之一将治疗剂或诊断剂从一个身体隔室递送至一个或多个其它身体隔室的药物组合物和方法：具有多个官能团的聚合物，其中至少一个共价结合 至少一种与治疗剂或诊断剂共价结合的细胞摄取促进剂; 或与其结合的聚合物和至少一种细胞摄取促进剂; 所述聚合物还包含多个官能团，其中至少一个与治疗剂或诊断剂共价结合。

公开(公告)号：US20060029667A1

公开(公告)日：2006-02-09

申请号：US11170652

申请日：2005-06-29

申请人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick Sinko ,  Tamara Minko ,  Gregory Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Park ,  Bo Qiu ,  Pankaj Paranjpe

发明人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick Sinko ,  Tamara Minko ,  Gregory Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Park ,  Bo Qiu ,  Pankaj Paranjpe

IPC分类号： A61K9/20

CPC分类号： A61K47/48346 ,  A61K38/08 ,  A61K47/60 ,  A61K47/62 ,  A61K47/665 ,  B82Y5/00

摘要： The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

公开(公告)号：US20150024789A1

公开(公告)日：2015-01-22

申请号：US13977029

申请日：2012-06-08

申请人： Aras Bilgen ,  Dirk Hohndel ,  Michael Leibowitz

发明人： Aras Bilgen ,  Dirk Hohndel ,  Michael Leibowitz

IPC分类号： G06F17/30 ,  H04W4/02 ,  H04W4/04

CPC分类号： G06F16/29 ,  G06F16/9537 ,  G06Q10/10 ,  G06Q10/1093 ,  H04W4/025 ,  H04W4/029

摘要： Systems and methods may provide for detecting an event on a mobile platform, and determining a physical location of the mobile platform in response to the event. The event may be one of a time-based trigger that identifies a colloquial name for the physical location and a single-action request from a user interface of the mobile platform. In one example, the time-based trigger is scheduled based on a calendar entry that includes the colloquial name and is created before the mobile platform enters the physical location.

摘要翻译： 系统和方法可以提供用于检测移动平台上的事件，以及响应于事件来确定移动平台的物理位置。 该事件可以是基于时间的触发器之一，其标识物理位置的口语名称和来自移动平台的用户界面的单个动作请求。 在一个示例中，基于包括口语名称并且在移动平台进入物理位置之前创建的日历条目来调度基于时间的触发器。

公开(公告)号：US20110087004A1

公开(公告)日：2011-04-14

申请号：US12818955

申请日：2010-06-18

申请人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick J. Sinko ,  Tamara Minko ,  Gregory C. Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Hee Park ,  Bo Qiu ,  Pankaj Paranjpe

发明人： Srinivasan Ramanathan ,  Stanley Stein ,  Michael Leibowitz ,  Patrick J. Sinko ,  Tamara Minko ,  Gregory C. Williams ,  Goubao Zhang ,  Xiaoping Zhang ,  Shahrair Pooyan ,  Seong Hee Park ,  Bo Qiu ,  Pankaj Paranjpe

IPC分类号： C07K7/06

CPC分类号： A61K38/08 ,  A61K47/60 ,  A61K47/62 ,  A61K47/665 ,  B82Y5/00

摘要： The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.

摘要翻译： 本发明涉及通过施用以下缀合物之一将治疗剂或诊断剂从一个身体隔室递送至一个或多个其它身体隔室的药物组合物和方法：具有多个官能团的聚合物，其中至少一个共价结合 至少一种与治疗剂或诊断剂共价结合的细胞摄取促进剂; 或与其结合的聚合物和至少一种细胞摄取促进剂; 所述聚合物还包含多个官能团，其中至少一个与治疗剂或诊断剂共价结合。