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1.发明授权Isolation of membrane vesicles from biological fluids and methods of using same 有权从生物液体中分离膜囊泡及其使用方法公开(公告)号：US08758991B2
公开(公告)日：2014-06-24
申请号：US12298467
申请日：2007-04-26
Applicant: Jon Klein , Elias Klein , Michael Merchant
Inventor： Jon Klein , Elias Klein , Michael Merchant
IPC: C12Q1/00
CPC classification number: G01N33/6842 , C07K1/34
Abstract: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.
Abstract translation: 提供了从生物流体样品中分离膜囊泡的方法。 在一些实施方案中，所述方法包括提供包含膜囊泡的生物流体样品; 通过包含平均孔径在约0.01μm至约0.15μm之间的过滤器的过滤模块过滤生物流体样品; 并从所述过滤模块收集包含所述膜囊泡的滞留物，从而将所述膜泡与所述生物流体样品隔离。
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2.发明授权公开(公告)号：US08394601B2
公开(公告)日：2013-03-12
申请号：US13234756
申请日：2011-09-16
Applicant: Jon B. Klein , Michael Merchant , Grzegorz Boratyn
Inventor： Jon B. Klein , Michael Merchant , Grzegorz Boratyn
CPC classification number: G01N33/6893 , G01N2800/042 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
Abstract: Methods and kits are provided for diagnosing a kidney disease, or the risk thereof, in a subject. The methods include determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
Abstract translation: 提供了用于诊断受试者的肾脏疾病或其风险的方法和试剂盒。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。
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3.发明申请ISOLATION OF MEMBRANE VESICLES FROM BIOLOGICAL FLUIDS AND METHODS OF USING SAME 有权从生物流体中分离膜片和使用它们的方法公开(公告)号：US20090258379A1
公开(公告)日：2009-10-15
申请号：US12298467
申请日：2007-04-26
Applicant: Jon Klein , Elias Klein , Michael Merchant
Inventor： Jon Klein , Elias Klein , Michael Merchant
CPC classification number: G01N33/6842 , C07K1/34
Abstract: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.
Abstract translation: 提供了从生物流体样品中分离膜囊泡的方法。 在一些实施方案中，所述方法包括提供包含膜囊泡的生物流体样品; 通过包含平均孔径在约0.01μm至约0.15μm之间的过滤器的过滤模块过滤生物流体样品; 并从所述过滤模块收集包含所述膜囊泡的滞留物，从而将所述膜泡与所述生物流体样品隔离。
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公开(公告)号：US08221352B2
公开(公告)日：2012-07-17
申请号：US12697148
申请日：2010-01-29
Applicant: Michael Merchant
Inventor： Michael Merchant
IPC: A61M5/00
CPC classification number: A61B5/153 , A61B5/15003 , A61B5/150389 , A61B5/150503 , A61B5/150641 , A61B5/15074 , A61M5/3202 , A61M5/3213 , A61M5/3273
Abstract: Techniques disclosed herein include a disposable safety needle assembly and safety enclosure for internally shielding a used or contaminated needle. The needle assembly has a needle cannula slidably disposed within a safety enclosure. The safety enclosure includes an internally disposed flexible safety member. The flexible safety member has face portion transversely situated and having a safety feature disposed to the needle and that slides thereon. Retracting the needle within the safety enclosure to a point wherein the sharp tip of the needle is beyond the needle protection section of the flexible member causes the protection section to travel transversely to the direction of motion of the needle. As a result, the safety feature receives the sharp tip of the needle and prevents the needle from exiting the enclosure, thereby maintaining the needle safely after use.
Abstract translation: 本文公开的技术包括用于内部屏蔽使用或污染的针的一次性安全针组件和安全壳。 针组件具有可滑动地设置在安全壳体内的针套管。 安全壳包括一个内置的柔性安全构件。 柔性安全构件具有横向定位的面部部分，并且具有设置在针上并在其上滑动的安全特征。 将针安全壳内的针头缩回至针尖的尖端超过柔性部件的针保护部分的位置，使得保护部分横向于针的运动方向行进。 结果，安全特征接收针的锋利尖端并防止针离开外壳，从而在使用后保持针头安全。
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5.发明申请公开(公告)号：US20120009606A1
公开(公告)日：2012-01-12
申请号：US13234756
申请日：2011-09-16
Applicant: Jon B. Klein , Michael Merchant , Grzegorz Boratyn
Inventor： Jon B. Klein , Michael Merchant , Grzegorz Boratyn
CPC classification number: G01N33/6893 , G01N2800/042 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
Abstract: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
Abstract translation: 目前公开的主题提供了在受试者中诊断肾脏疾病或其风险的方法。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20090081713A1
公开(公告)日：2009-03-26
申请号：US12234401
申请日：2008-09-19
Applicant: Jon B. Klein , Michael Merchant , Grzegorz Boratyn
Inventor： Jon B. Klein , Michael Merchant , Grzegorz Boratyn
CPC classification number: G01N33/6893 , G01N2800/042 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
Abstract: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
Abstract translation: 目前公开的主题提供了在受试者中诊断肾脏疾病或其风险的方法。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。
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公开(公告)号：US20080021763A1
公开(公告)日：2008-01-24
申请号：US11483272
申请日：2006-07-06
Applicant: Michael Merchant
Inventor： Michael Merchant
IPC: G06F17/30
CPC classification number: G06Q30/02 , G06Q30/0203
Abstract: Methods for collecting accurate perception data points related to a given item from a set of respondents by offering an incentive that benefits the respondent or respondents who submit data points that match most closely to a calculated value of the data points collected. Provides methods for collecting perception data points by a market research service provider that offers considerably greater information and convenience to prospective initiators of market research service who desire to have a given item be assessed and offer the chances to win incentives to encourage accurate assessment and participation by respondents. Helps one to understand how others perceive the value of a given item so that one may make an educated judgment on how to price such item. The object of the invention is that the more accurate the perception data given by respondents, the more likely the respondents will win the incentive.
Abstract translation: 通过提供一种激励措施来收集与一组受访者相关的指定项目的准确感知数据点的方法，该激励措施有利于答复者或答复者提交与收集的数据点的计算值最匹配的数据点。 提供市场研究服务提供商收集感知数据点的方法，为希望对某个项目进行评估的市场研究服务的潜在发起者提供更大的信息和便利，并提供获得奖励以鼓励准确评估和参与的机会 受访者 帮助人们了解别人如何看待给定项目的价值，以便人们对如何对这样的项目进行定价做出有根据的判断。 本发明的目的在于，答复者给出的感知数据越准确，受访者越有可能赢得激励。
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公开(公告)号：US09895489B2
公开(公告)日：2018-02-20
申请号：US14841963
申请日：2015-09-01
Applicant: Michael Merchant
Inventor： Michael Merchant
CPC classification number: A61M5/1626 , A61M5/158 , A61M5/3243 , A61M5/34 , A61M2005/1585 , A61M2005/1586 , A61M2005/3247 , A61M2005/3249 , A61M2005/341 , A61M2005/342
Abstract: A disposable safety needle assembly and safety enclosure for internally shielding a used or contaminated needle includes a needle assembly having a needle cannula slidably disposed within a safety enclosure. An angular orientation to the needle within the enclosure maintains an insertion angle allowing the safety enclosure to remain substantially flush with a dermal surface during and while the needle is inserted. The safety enclosure also includes an internally disposed flexible safety member. The flexible safety member has face portion transversely situated and having a safety feature disposed to the needle and that slides thereon. Retracting the needle within the safety enclosure to a point wherein the sharp tip of the needle is beyond the needle protection section of the flexible member causes the protection section to travel transversely to the direction of motion of the needle. As a result, the safety feature receives the sharp tip of the needle.
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9.发明授权公开(公告)号：US08039227B2
公开(公告)日：2011-10-18
申请号：US12234401
申请日：2008-09-19
Applicant: Jon B. Klein , Michael Merchant , Grzegorz Boratyn
Inventor： Jon B. Klein , Michael Merchant , Grzegorz Boratyn
CPC classification number: G01N33/6893 , G01N2800/042 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
Abstract: Methods for diagnosing a kidney disease, or the risk thereof, in a subject are provided. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.
Abstract translation: 提供了用于诊断受试者的肾脏疾病或其风险的方法。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。
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公开(公告)号：US20190082866A1
公开(公告)日：2019-03-21
申请号：US16015872
申请日：2018-06-22
Applicant: Terry Michael Merchant
Inventor： Terry Michael Merchant
Abstract: A unitary bedsheet and cover are provided for applying bedding to a mattress. A mattress encasement surrounds the mattress, much like a pillow case and pillow. A flap is provided to cover the opening in the encasement tuck beneath the mattress. A top sheet is attached along a foot end of the mattress encasement. The unitary bedsheet system may have elastic panels to provide a snug fit of the encasement around the mattress. Once installed the sheets of unitary unit do not move or come untucked and the fitted encasement stays tight to the mattress.
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