公开(公告)号：US09895489B2

公开(公告)日：2018-02-20

申请号：US14841963

申请日：2015-09-01

Applicant: Michael Merchant

Inventor： Michael Merchant

IPC: A61M5/34 ,  A61M5/158 ,  A61M5/162 ,  A61M5/32

CPC classification number: A61M5/1626 ,  A61M5/158 ,  A61M5/3243 ,  A61M5/34 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/3247 ,  A61M2005/3249 ,  A61M2005/341 ,  A61M2005/342

Abstract: A disposable safety needle assembly and safety enclosure for internally shielding a used or contaminated needle includes a needle assembly having a needle cannula slidably disposed within a safety enclosure. An angular orientation to the needle within the enclosure maintains an insertion angle allowing the safety enclosure to remain substantially flush with a dermal surface during and while the needle is inserted. The safety enclosure also includes an internally disposed flexible safety member. The flexible safety member has face portion transversely situated and having a safety feature disposed to the needle and that slides thereon. Retracting the needle within the safety enclosure to a point wherein the sharp tip of the needle is beyond the needle protection section of the flexible member causes the protection section to travel transversely to the direction of motion of the needle. As a result, the safety feature receives the sharp tip of the needle.

公开(公告)号：US08039227B2

公开(公告)日：2011-10-18

申请号：US12234401

申请日：2008-09-19

Applicant: Jon B. Klein ,  Michael Merchant ,  Grzegorz Boratyn

Inventor： Jon B. Klein ,  Michael Merchant ,  Grzegorz Boratyn

IPC: C12Q1/02 ,  C07K7/00 ,  C07K7/18

CPC classification number: G01N33/6893 ,  G01N2800/042 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

Abstract: Methods for diagnosing a kidney disease, or the risk thereof, in a subject are provided. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.

Abstract translation: 提供了用于诊断受试者的肾脏疾病或其风险的方法。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。

公开(公告)号：US08758991B2

公开(公告)日：2014-06-24

申请号：US12298467

申请日：2007-04-26

Applicant: Jon Klein ,  Elias Klein ,  Michael Merchant

Inventor： Jon Klein ,  Elias Klein ,  Michael Merchant

IPC: C12Q1/00

CPC classification number: G01N33/6842 ,  C07K1/34

Abstract: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.

Abstract translation: 提供了从生物流体样品中分离膜囊泡的方法。 在一些实施方案中，所述方法包括提供包含膜囊泡的生物流体样品; 通过包含平均孔径在约0.01μm至约0.15μm之间的过滤器的过滤模块过滤生物流体样品; 并从所述过滤模块收集包含所述膜囊泡的滞留物，从而将所述膜泡与所述生物流体样品隔离。

公开(公告)号：US08394601B2

公开(公告)日：2013-03-12

申请号：US13234756

申请日：2011-09-16

Applicant: Jon B. Klein ,  Michael Merchant ,  Grzegorz Boratyn

Inventor： Jon B. Klein ,  Michael Merchant ,  Grzegorz Boratyn

IPC: C07K7/00 ,  G01N33/53 ,  H01J49/26 ,  H01J49/40

CPC classification number: G01N33/6893 ,  G01N2800/042 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

Abstract: Methods and kits are provided for diagnosing a kidney disease, or the risk thereof, in a subject. The methods include determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.

Abstract translation: 提供了用于诊断受试者的肾脏疾病或其风险的方法和试剂盒。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。

公开(公告)号：US20090258379A1

公开(公告)日：2009-10-15

申请号：US12298467

申请日：2007-04-26

Applicant: Jon Klein ,  Elias Klein ,  Michael Merchant

Inventor： Jon Klein ,  Elias Klein ,  Michael Merchant

IPC: G01N33/00 ,  C12N1/00 ,  C12Q1/00 ,  C07K1/14

CPC classification number: G01N33/6842 ,  C07K1/34

Abstract: Methods of isolating membrane vesicles from a biological fluid sample are provided. In some embodiments, the methods comprise providing a biological fluid sample comprising membrane vesicles; filtering the biological fluid sample through a filtration module comprising a filter having an average pore diameter of between about 0.01 um and about 0.15 um; and collecting from the filtration module a retentate comprising the membrane vesicles, thereby isolating the membrane vesicles from the biological fluid sample.

Abstract translation: 提供了从生物流体样品中分离膜囊泡的方法。 在一些实施方案中，所述方法包括提供包含膜囊泡的生物流体样品; 通过包含平均孔径在约0.01μm至约0.15μm之间的过滤器的过滤模块过滤生物流体样品; 并从所述过滤模块收集包含所述膜囊泡的滞留物，从而将所述膜泡与所述生物流体样品隔离。

公开(公告)号：US20170056586A1

公开(公告)日：2017-03-02

申请号：US14841963

申请日：2015-09-01

Applicant: Michael Merchant

Inventor： Michael Merchant

IPC: A61M5/162 ,  A61M5/158

CPC classification number: A61M5/1626 ,  A61M5/158 ,  A61M5/3243 ,  A61M5/34 ,  A61M2005/1585 ,  A61M2005/1586 ,  A61M2005/3247 ,  A61M2005/3249 ,  A61M2005/341 ,  A61M2005/342

Abstract: A disposable safety needle assembly and safety enclosure for internally shielding a used or contaminated needle includes a needle assembly having a needle cannula slidably disposed within a safety enclosure. An angular orientation to the needle within the enclosure maintains an insertion angle allowing the safety enclosure to remain substantially flush with a dermal surface during and while the needle is inserted. The safety enclosure also includes an internally disposed flexible safety member. The flexible safety member has face portion transversely situated and having a safety feature disposed to the needle and that slides thereon. Retracting the needle within the safety enclosure to a point wherein the sharp tip of the needle is beyond the needle protection section of the flexible member causes the protection section to travel transversely to the direction of motion of the needle. As a result, the safety feature receives the sharp tip of the needle.

Abstract translation: 用于内部屏蔽使用或污染的针的一次性安全针组件和安全壳包括具有可滑动地设置在安全壳体内的针管的针组件。 外壳内的针的角度取向保持插入角度，允许安全外壳在插针期间和针时保持与真皮表面基本齐平。 安全外壳还包括内部设置的柔性安全构件。 柔性安全构件具有横向定位的面部部分，并且具有设置在针上并在其上滑动的安全特征。 将针安全壳内的针头缩回至针尖的尖端超过柔性部件的针保护部分的位置，使得保护部分横向于针的运动方向行进。 因此，安全功能接收针尖尖端。

公开(公告)号：US20110125056A1

公开(公告)日：2011-05-26

申请号：US12697148

申请日：2010-01-29

Applicant: Michael Merchant

Inventor： Michael Merchant

IPC: A61M5/32 ,  A61B5/15

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150641 ,  A61B5/15074 ,  A61M5/3202 ,  A61M5/3213 ,  A61M5/3273

Abstract: A disposable safety needle assembly and safety enclosure means for internally shielding a used or contaminated needle is disclosed. The needle assembly has a needle cannula which is disposed and slidably within a safety enclosure. The safety enclosure includes an internally disposed flexible safety member situated substantially longitudinally within said flexible safety member, having a face portion transversely having a safety feature and being disposed to the needle and cooperatively sliding thereon. Retraction of the needle within the safety enclosure to a point wherein the sharp tip of the needle is beyond the needle protection section of the flexible member causes the protection section to travel transversely to the direction of motion of the needle and the safety feature receiving the sharp tip of the needle and preventing it from exiting the enclosure, thereby maintaining the needle safely after use.

Abstract translation: 公开了一种一次性安全针组件和用于内部屏蔽使用或污染的针的安全外壳装置。 针组件具有设置并可滑动地安装在安全壳体内的针套管。 安全壳包括内部设置的柔性安全构件，其基本纵向地设置在所述柔性安全构件内，具有横向具有安全特征的面部，并且设置在针上并在其上协同地滑动。 针头在安全壳体内的缩回至针尖的尖端超过柔性部件的针保护部分的位置使得保护部分横向于针的运动方向行进，并且安全特征接收尖锐的 针尖并防止其离开外壳，从而在使用后保持针头的安全。

公开(公告)号：US07062357B2

公开(公告)日：2006-06-13

申请号：US09960626

申请日：2001-09-21

Applicant: Michael Merchant ,  Richard Lund ,  Doug Mann

Inventor： Michael Merchant ,  Richard Lund ,  Doug Mann

IPC: G05D23/00

CPC classification number: G05B17/02 ,  G01M7/022

Abstract: A multiple region convolver includes tapering between successive models of a physical system. The tapering is performed during a transition period.

公开(公告)号：US08221352B2

公开(公告)日：2012-07-17

申请号：US12697148

申请日：2010-01-29

Applicant: Michael Merchant

Inventor： Michael Merchant

IPC: A61M5/00

CPC classification number: A61B5/153 ,  A61B5/15003 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150641 ,  A61B5/15074 ,  A61M5/3202 ,  A61M5/3213 ,  A61M5/3273

Abstract: Techniques disclosed herein include a disposable safety needle assembly and safety enclosure for internally shielding a used or contaminated needle. The needle assembly has a needle cannula slidably disposed within a safety enclosure. The safety enclosure includes an internally disposed flexible safety member. The flexible safety member has face portion transversely situated and having a safety feature disposed to the needle and that slides thereon. Retracting the needle within the safety enclosure to a point wherein the sharp tip of the needle is beyond the needle protection section of the flexible member causes the protection section to travel transversely to the direction of motion of the needle. As a result, the safety feature receives the sharp tip of the needle and prevents the needle from exiting the enclosure, thereby maintaining the needle safely after use.

Abstract translation: 本文公开的技术包括用于内部屏蔽使用或污染的针的一次性安全针组件和安全壳。 针组件具有可滑动地设置在安全壳体内的针套管。 安全壳包括一个内置的柔性安全构件。 柔性安全构件具有横向定位的面部部分，并且具有设置在针上并在其上滑动的安全特征。 将针安全壳内的针头缩回至针尖的尖端超过柔性部件的针保护部分的位置，使得保护部分横向于针的运动方向行进。 结果，安全特征接收针的锋利尖端并防止针离开外壳，从而在使用后保持针头安全。

公开(公告)号：US20120009606A1

公开(公告)日：2012-01-12

申请号：US13234756

申请日：2011-09-16

Applicant: Jon B. Klein ,  Michael Merchant ,  Grzegorz Boratyn

Inventor： Jon B. Klein ,  Michael Merchant ,  Grzegorz Boratyn

IPC: G01N33/53 ,  H01J49/26 ,  H01J49/40 ,  C07K16/00

CPC classification number: G01N33/6893 ,  G01N2800/042 ,  G01N2800/347 ,  G01N2800/50 ,  G01N2800/52 ,  G01N2800/56

Abstract: The presently-disclosed subject matter provides methods for diagnosing a kidney disease, or the risk thereof, in a subject. The methods comprise determining an amount of at least one peptide biomarker disclosed herein in a biological sample from the subject and comparing the amount of the at least one peptide in the sample with a control level, wherein if the amount determined is different than the control level, the subject is diagnosed as having, or at an increased risk of developing, the kidney disease.

Abstract translation: 目前公开的主题提供了在受试者中诊断肾脏疾病或其风险的方法。 所述方法包括测定来自受试者的生物样品中本文公开的至少一种肽生物标志物的量，并将样品中的至少一种肽的量与对照水平进行比较，其中如果所测定的量不同于对照水平 ，被诊断为患有或有增加的发展为肾脏疾病的风险。