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公开(公告)号：US4828587A
公开(公告)日：1989-05-09
申请号：US75726
申请日：1987-07-20
申请人： Ulrich Baurmeister , Michael Pelger
发明人： Ulrich Baurmeister , Michael Pelger
CPC分类号： A61M5/36 , B01D19/0031 , B01D63/021 , B01D63/024 , B01D63/025 , B01D63/026 , B01D63/04 , B01D2319/06
摘要： A device for separating gas bubbles from infusion fluids or human-body fluids by means of fluid-repellent, gas-permeable, microporous degassing elements with a casing, which has an inlet opening for the fluid to be degassed, an outlet opening for the degassed fluid, and at least one outlet opening for gas. The degassing element is disposed at least in the area of the casing in which gas bubbles occur, wherein the degassing element comprises at least one degassing capillary whose inner cavity is closed against the passage of fluid, and an outlet opening for the gas. Preferably, this device is used as an infusion filter, in which case a wettable, gas-impermeable microporous filter is additionally disposed in the casing. The wettable, gas-impermeable microporous filter may comprise filter capillaries, in which case the filter capillaries and the degassing capillaries can be disposed in such a way that they have only one common embedment.
摘要翻译： 一种用于通过防液体，气体可渗透的微孔脱气元件与输液或人体液体分离气泡的装置，其具有用于待脱气的流体的入口开口，用于待脱气的流体的出口开口 流体和至少一个用于气体的出口。 脱气元件至少设置在气泡发生的壳体的区域中，其中脱气元件包括至少一个脱气毛细管，其内腔相对于流体的通道而封闭，以及用于气体的出口。 优选地，该装置用作输液过滤器，在这种情况下，另外在壳体中设置可润湿的气体不可渗透的微孔过滤器。 可湿透的不透气微孔过滤器可以包括过滤器毛细管，在这种情况下，过滤器毛细管和脱气毛细管可以以这样的方式设置，使得它们仅具有一个共同的嵌入。
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公开(公告)号：US4814440A
公开(公告)日：1989-03-21
申请号：US103345
申请日：1987-10-01
申请人： Joachim Behnke , Helmut Schulze , Ernst Berg , Michael Pelger
发明人： Joachim Behnke , Helmut Schulze , Ernst Berg , Michael Pelger
IPC分类号： C08B1/00 , B01D71/10 , C08L1/00 , D01D5/24 , D01F2/00 , D06M11/00 , D06M11/05 , D06M11/38 , D06M13/192 , D06M23/00 , D06M101/00 , D06M101/02 , D06M101/06 , D21C5/00 , D21C9/00 , D21H11/12 , C08B1/02 , C08B16/00
摘要： The invention relates to a process for obtaining extractive-material-reduced cellulose with a low LAL reaction, wherein cotton linters or wood pulps, subsequent to the customary digesting treatment, are subjected for 1 to 10 hours to hydraulic washing with water, lye with a concentration of less than 5 g/l alkali content, or with a diluted acid containing less than 5 g/l acid at temperatures of 120.degree. to 180.degree. C. and under a pressure of 2 to 20 bar.The resulting cellulose is used for the manufacture of hemodialysis and/or hemofiltration membranes in the form of flat membranes, tubular membranes or hollow filaments by regeneration of a cellulose solution containing the extractive-material-reduced cellulose with a low LAL reaction.The regeneration may be effected from solutions of cellulose cuoxam, cellulose xanthate, or solutions of cellulose in tertiary amine oxide or in an LiCl-containing solvent.
摘要翻译： 本发明涉及一种获得具有低LAL反应的萃取材料还原的纤维素的方法，其中在常规消化处理之后将棉绒或木浆进行1至10小时以水洗液体，碱 浓度小于5g / l碱含量，或在120℃至180℃的温度和2至20巴的压力下，使用含有少于5g / l酸的稀酸。 所得到的纤维素用于通过用低LAL反应再生含有萃取材料还原的纤维素的纤维素溶液来制造平膜，管状膜或中空细丝形式的血液透析和/或血液滤过膜。 再生可以由纤维素cuoxam，黄原酸纤维素或纤维素在叔胺氧化物溶液中或在含LiCl的溶剂中的溶液进行。
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公开(公告)号：US4673506A
公开(公告)日：1987-06-16
申请号：US801520
申请日：1985-11-25
申请人： Werner Henne , Michael Pelger
发明人： Werner Henne , Michael Pelger
CPC分类号： B01D67/0095 , A01N31/02 , A61L2/18 , B01D65/02 , B01D65/022 , B01D2321/08 , B01D2321/168
摘要： A cleaning treatment is disclosed for the blood compartments of dialyzators which is effected still in the preparation stage. The dialyzators contain membranes of cellulose in the form of hollow filaments, tubes or flat foils. The cleaning treatment embraces the following measures:washing with water or aqueous solutions and evacuation of the compartments, then filling with a mixture of water, glycerin and alcohol and drying after a renewed evacuation--or, filling with water or aqueous solutions and subsequently closing the entrance and exit of the blood compartment. As a third measure, the compartments are sterilized with gamma radiation and/or ethylene oxide and/or superheated steam.
摘要翻译： 公开透析器的血液隔室的清洁处理，其仍在制备阶段中进行。 透析器含有中空丝，管或扁平箔形式的纤维素膜。 清洁处理包括以下措施：用水或水溶液洗涤并排空隔室，然后用水，甘油和酒精的混合物填充，并在更新排空后干燥，或者用水或水溶液填充，然后关闭 血液室的入口和出口。 作为第三个措施，隔室用γ辐射和/或环氧乙烷和/或过热蒸汽灭菌。
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4.发明授权
公开(公告)号：US4668396A
公开(公告)日：1987-05-26
申请号：US765530
申请日：1985-08-14
申请人： Ulrich Baurmeister , Walter Brodowski , Michael Diamantoglou , Gustav Dunweg , Werner Henne , Michael Pelger , Helmut Schulze
发明人： Ulrich Baurmeister , Walter Brodowski , Michael Diamantoglou , Gustav Dunweg , Werner Henne , Michael Pelger , Helmut Schulze
摘要： A dialysis membrane used for hemodialysis having a structure comprised of flat films, blown films or tubular threads of substitution-modified cellulose, in which the effects of complement activation and leukopenia are clearly reduced. The average degree of substitution of the modified cellulose is 0.02 to 0.07. Dialysis membranes, which have proven successful within the scope of the invention, contain modified cellulose, having a structure represented by the formula cellulose-Z, wherein Z represents the group --R'--X--Y.X is at least one member selected from the group consisting of ##STR1## Y is at least one member selected from the group consisting of --R, --NR.sub.2, --Si(OR").sub.3, --SO.sub.3 H, --COOH, --PO.sub.3 H.sub.2, --N.sup.+ HR.sub.2, --OR" and the salts thereof.R' is at least one member selected from the group consisting of an alkylenes cycloalkylenes and arylenes having a total of 1 to 25 carbon atoms.R" is a hydrogen atom or R.R is at least one member selected from the group consisting of an alkyls with 1 to 5 carbon atoms, cycloalkyls and an aryls.
摘要翻译： 用于血液透析的透析膜具有包含补体活化和白细胞减少的效果的取代改性纤维素的平膜，吹膜或管状线构成的结构。 改性纤维素的平均取代度为0.02〜0.07。 已经证明在本发明范围内成功的透析膜含有具有式Z-基团-R'-X-Y所示结构式纤维素-Z的改性纤维素。 X是从由以下组成的组中选择的至少一个成员：Y是至少一个选自-R，-NR2，-Si（OR“）3，-SO3H， -COOH，-PO 3 H 2，-N + HR 2，-OR“及其盐。 R'是选自具有总共1至25个碳原子的亚烷基环烷烃和亚芳基中的至少一种。 R“是氢原子或R.R是选自具有1至5个碳原子的烷基，环烷基和芳基中的至少一个。
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公开(公告)号：US5853647A
公开(公告)日：1998-12-29
申请号：US806924
申请日：1997-02-26
CPC分类号： B01D67/0088 , B01D67/0095 , B01D71/10
摘要： Properties of cellulosic membranes such as the length and the ultrafiltration rate are stabilized by warmth/humidity conditioning, whereby temperatures in a range of about 30.degree. to 60.degree. C. and relative humidities in a range of about 10 to 60% are suitable. The membranes may be enveloped at a relative humidity of about 40 to 60% and at about 20.degree. to 25.degree. C. in a packaging which is at least substantially impermeable to the passage of moisture before being subjected to the conditioning.
摘要翻译： 纤维素膜的性质如长度和超滤速率通过温暖/湿度调节来稳定，由此温度在约30℃至60℃的范围内，相对湿度在约10至60％的范围内是合适的。 膜可以在约40至60％和约20至25℃的相对湿度下包封，该包装在经受调理之前至少基本上不透水分通过。
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公开(公告)号：US4772393A
公开(公告)日：1988-09-20
申请号：US81534
申请日：1987-08-04
申请人： Michael Pelger , Helmut Schulze
发明人： Michael Pelger , Helmut Schulze
摘要： The invention relates to a dialysis membrane of regenerated cellulose and to a process for its production. Isocyanate prepolymers with an average molecular weight of 300 to 50,000, which are soluble in organic solvents other than solvents reacting with isocyanate groups and dissolving cellulose, are bound chemically at least to one membrane surface of the dialysis membrane. The dialysis membrane of the present invention substantially eliminates the symptoms of leukopenia and complement activation.
摘要翻译： 本发明涉及再生纤维素的透析膜及其生产方法。 平均分子量为300〜50,000的异氰酸酯预聚物，其可溶于与异氰酸酯基反应的溶剂和溶解纤维素以外的有机溶剂中，化学键合在透析膜的至少一个膜表面。 本发明的透析膜基本上消除了白细胞减少症和补体激活的症状。
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7.发明授权
公开(公告)号：US4741927A
公开(公告)日：1988-05-03
申请号：US871761
申请日：1986-05-16
申请人： Michael Pelger , Helmut Schulze
发明人： Michael Pelger , Helmut Schulze
摘要： The invention relates to a method for the production of a dialysis membrane of regenerated cellulose. Isocyanate prepolymers with an average molecular weight of 300 to 50,000, which are soluble in organic solvents other than solvents reacting with isocyanate groups and dissolving cellulose, are bound chemically at least to one membrane surface of the dialysis membrane. The dialysis membrane made by the process of the present invention substantially eliminates the symptoms of leukopenia and complement activation.
摘要翻译： 本发明涉及生产再生纤维素透析膜的方法。 平均分子量为300〜50,000的异氰酸酯预聚物，其可溶于与异氰酸酯基反应的溶剂和溶解纤维素以外的有机溶剂中，化学键合在透析膜的至少一个膜表面。 通过本发明的方法制备的透析膜基本上消除了白细胞减少症和补体激活的症状。
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