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1.发明授权
公开(公告)号：US4668396A
公开(公告)日：1987-05-26
申请号：US765530
申请日：1985-08-14
申请人： Ulrich Baurmeister , Walter Brodowski , Michael Diamantoglou , Gustav Dunweg , Werner Henne , Michael Pelger , Helmut Schulze
发明人： Ulrich Baurmeister , Walter Brodowski , Michael Diamantoglou , Gustav Dunweg , Werner Henne , Michael Pelger , Helmut Schulze
摘要： A dialysis membrane used for hemodialysis having a structure comprised of flat films, blown films or tubular threads of substitution-modified cellulose, in which the effects of complement activation and leukopenia are clearly reduced. The average degree of substitution of the modified cellulose is 0.02 to 0.07. Dialysis membranes, which have proven successful within the scope of the invention, contain modified cellulose, having a structure represented by the formula cellulose-Z, wherein Z represents the group --R'--X--Y.X is at least one member selected from the group consisting of ##STR1## Y is at least one member selected from the group consisting of --R, --NR.sub.2, --Si(OR").sub.3, --SO.sub.3 H, --COOH, --PO.sub.3 H.sub.2, --N.sup.+ HR.sub.2, --OR" and the salts thereof.R' is at least one member selected from the group consisting of an alkylenes cycloalkylenes and arylenes having a total of 1 to 25 carbon atoms.R" is a hydrogen atom or R.R is at least one member selected from the group consisting of an alkyls with 1 to 5 carbon atoms, cycloalkyls and an aryls.
摘要翻译： 用于血液透析的透析膜具有包含补体活化和白细胞减少的效果的取代改性纤维素的平膜，吹膜或管状线构成的结构。 改性纤维素的平均取代度为0.02〜0.07。 已经证明在本发明范围内成功的透析膜含有具有式Z-基团-R'-X-Y所示结构式纤维素-Z的改性纤维素。 X是从由以下组成的组中选择的至少一个成员：Y是至少一个选自-R，-NR2，-Si（OR“）3，-SO3H， -COOH，-PO 3 H 2，-N + HR 2，-OR“及其盐。 R'是选自具有总共1至25个碳原子的亚烷基环烷烃和亚芳基中的至少一种。 R“是氢原子或R.R是选自具有1至5个碳原子的烷基，环烷基和芳基中的至少一个。
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公开(公告)号：US5427684A
公开(公告)日：1995-06-27
申请号：US73359
申请日：1993-06-07
摘要： A dialysis membrane for hemodialysis in the form of sheet films, tubular films, or hollow fibers is composed of a polysaccharide ether. The polysaccharide ether has a structure given by the formula ##STR1## in which cell is the skeleton of the unmodified cellulose molecule or of the chitin molecule, each with no hydroxyl groups, s is equal to 3 for the unmodified cellulose molecule and 2 for the chitin molecule, and x is the degree of etherification, which is in the range from 0.001 to 0.079, and R is an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, arylalkyl, arylalkenyl, and/or arylalkynyl group with 3 to 25 carbon atoms, and/or the radical of a heterocyclic compound with 3 to 25 carbon atoms, in which the carbon chain may be interrupted by oxygen or sulfur atoms.
摘要翻译： 以薄膜，管状薄膜或中空纤维的形式进行血液透析的透析膜由多糖醚构成。 多糖醚具有由式“IMAGE”给出的结构，其中细胞是未修饰的纤维素分子或几丁质分子的骨架，每个不含羟基，对于未修饰的纤维素分子s等于3，对于未修饰的纤维素分子，s等于3 甲壳素分子，x是醚化度，其范围为0.001至0.079，R为任选取代的烷基，烯基，炔基，环烷基，环烯基，环炔基，芳基，芳基烷基，芳基烯基和/或芳基炔基 具有3至25个碳原子，和/或具有3至25个碳原子的杂环化合物的基团，其中碳链可被氧或硫原子间隔开。
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公开(公告)号：US4708985A
公开(公告)日：1987-11-24
申请号：US360146
申请日：1982-03-22
CPC分类号： C08L67/02
摘要： The invention relates to a hydrophilic moulding compound of homopolyester and/or copolyester which contains 1 to 20 percent by weight of an alkaline and/or alkaline-earth salt of salt-forming polymer and/or copolymers from ethylenic unsaturated monomers as finely dispersed filling material, having in particualr a maximum particle size of 1 um, the salt-forming polymers being composed in particular of the following single monomers or mixtures thereof: vinyl-sulfonic acid, acrylamidoalkylene-sulfonic acid, sulfonated styrene, acrylic acid, methacrylic acid, maleic acid, fumaric acid, itaconic acid, crotonic acid, vinyl-phosphonic acid, monoalkyl ester of maleic acid, monoalkyl ester of fumaric acid.The invention also relates to a process according to which the salts are preferably added to the polycondensation mixture of the polyester starting materials before and/or during poly-condensation as a suspension in polyhydric alcohol.The moulding compound is preferably used for making filament yarns, or staple fibers.
摘要翻译： 本发明涉及均聚酯和/或共聚酯的亲水性模塑料，其含有1-20重量％的成盐聚合物的碱和/或碱土金属盐和/或由烯属不饱和单体作为精细分散的填充材料的共聚物 ，特别是最大粒度为1um，成盐聚合物特别由以下单体或其混合物组成：乙烯基磺酸，丙烯酰氨基亚烷基磺酸，磺化苯乙烯，丙烯酸，甲基丙烯酸，马来酸 酸，富马酸，衣康酸，巴豆酸，乙烯基膦酸，马来酸的单烷基酯，富马酸的单烷基酯。 本发明还涉及一种方法，根据该方法，所述盐优选在聚缩合之前和/或期间作为多元醇中的悬浮液加入到聚酯原料的缩聚混合物中。 成型化合物优选用于制造长丝纱线或短纤维。
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公开(公告)号：US5087366A
公开(公告)日：1992-02-11
申请号：US453797
申请日：1989-12-20
摘要： A biocompatible dialysis membrane for hemodialysis in the form of flat sheets, tubular sheets or hollow filaments is disclosed. The dialysis membrane comprises a mixed polysaccharide ester of acetic acid, and/or propionic acid and/or butyric acid and has a structure represented by the formula ##STR1## wherein Cell denotes the skeleton of the polysaccharide molecule without hydroxyl groups; a, b, p, and s are numbers wherein s is a maximum degreee of substitution and the following equations are satisfied: ##EQU1## with the provision that, if a=0, then p and b must be greater than 0 and, if p or b=0, then a must be greater than 0.
摘要翻译： 公开了一种用于血液透析的生物相容性透析膜，其为扁平片，管状片或中空细丝。 透析膜包含乙酸和/或丙酸和/或丁酸的混合多糖酯，并具有由式“IMAGE”表示的结构，其中Cell表示无羟基的多糖分子的骨架; a，b，p和s是其中s是最大取代度并且满足以下等式的数字：a + p + b =（0.5）（s）至（0.95）（s）p + b =（0.13 ）（s）至（0.95）（s）; a =（0至0.83）（s）; b =（0〜0.9）（s）; 并且p =（0至0.9）（s），条件是如果a = 0，则p和b必须大于0，并且如果p或b = 0，则a必须大于0。
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5.发明授权Water-insoluble fibers of cellulose acetate, cellulose propionate and cellulose butyrate with an extremely high absorptive capacity for water and physiological liquids 失效乙酸纤维素，丙酸纤维素和丁酸纤维素的水不溶性纤维，对水和生理液体具有极高的吸收能力
公开(公告)号：US4543409A
公开(公告)日：1985-09-24
申请号：US560285
申请日：1983-12-12
CPC分类号： D01F2/28 , A61L15/28 , C08B3/00 , Y10T428/2913
摘要： The invention refers to water-insoluble fibers of cellulose acetate cellulose propionate and cellulose butyrate with an extremely high absorptive capacity for water and physiological liquids and to a process for their preparation.
摘要翻译： 本发明涉及醋酸纤维素丙酸纤维素和丁酸纤维素的水不溶性纤维，对水和生理液体具有极高的吸收能力及其制备方法。
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公开(公告)号：US6019925A
公开(公告)日：2000-02-01
申请号：US856861
申请日：1997-05-15
IPC分类号： A61M1/16 , B01D69/02 , B01D69/04 , B01D69/06 , B01D69/08 , B01D71/10 , B01D71/12 , B01D71/14 , B01D71/22 , C08J9/28
摘要： A method for producing cellulosic dialysis membranes in the form of flat, tubular, or hollow fiber membranes by spinning a spinning solution of cellulose and/or modified cellulose, a tertiary amine oxide, and additional liquids and additives such as stabilizers, pore formers and the like is provided. The method operates at high takeoff speed and produces membranes for the low, middle, and high flux ranges. The membranes show practically no aging and have a stable structure. The oxidative breakdown of cellulose in the manufacture of the membranes is extremely low and hemocompatability is very good.
摘要翻译： 通过纺丝纤维素和/或改性纤维素的纺丝溶液，叔胺氧化物以及其它液体和添加剂例如稳定剂，成孔剂和平滑管状或中空纤维膜的形式制备纤维素透析膜的方法 喜欢被提供。 该方法以高起飞速度运行，并产生用于低，中，高通量范围的膜。 膜几乎没有老化，结构稳定。 纤维素在膜的制造中的氧化分解极低，血液可兼容性非常好。
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7.发明授权Modified chitin for biocompatible dialysis membranes III and process for preparation of modified cellulose and modified chitin for use therewith 失效生物可渗透膜III的改性化合物及其改性纤维素的制备方法及其使用的改性酪氨酸
公开(公告)号：US5093488A
公开(公告)日：1992-03-03
申请号：US599821
申请日：1990-10-19
申请人： Michael Diamantoglou
发明人： Michael Diamantoglou
IPC分类号： C08B3/00 , B01D71/08 , B01D71/10 , B01D71/12 , C08B13/00 , C08B15/00 , C08B15/06 , C08B37/08
摘要： A modified cellulose and/or chitin for biocompatible dialysis membranes having a structure represented by the formula ##STR1## wherein cell is cellulose or chitin, in each case without hydroxyl groups, s=3 in the case of cellulose and s=2 in the case of chitin, R' is CH.sub.3 and/or C.sub.2 H.sub.5 and/or C.sub.3 H.sub.7, X denotes specified functional groups, R" is H or R, R"' denotes R, x+t=0.75 to 2.85, t=0 to 2.85, x=0 to 2.85, and r=0 to 1. A process for preparation of the cellulose and/or chitin derivatives is also disclosed.
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8.发明授权
公开(公告)号：US5055570A
公开(公告)日：1991-10-08
申请号：US389767
申请日：1989-08-04
申请人： Michael Diamantoglou
发明人： Michael Diamantoglou
摘要： A cellulose derivative comprising substitution-modified cellulose regenerated from a cuprammonium solution, the substituents being ester groups, wherein the acyl group represents one or more, optionally substituted, carbon chains with 10-36 carbon atoms, or a residue containing at least one aromatic and/or heterocyclic, optionally substituted, ring, or wherein the substituents are carbamate groups, the carbamoyl group of which represents a group containing one or more, optionally substituted, carbon chains with 2-36 carbon atoms, or a group containing at least one aromatic and/or heterocyclic, optionally substituted, ring. A dialysis membrane made from the substitution-modified cellulose, typically in the form of a flat film, a tubular film, or a hollow filament, is also disclosed.
摘要翻译： 一种纤维素衍生物，其包含由铜铵溶液再生的取代改性纤维素，所述取代基为酯基，其中所述酰基代表一个或多个任选取代的具有10-36个碳原子的碳链，或含有至少一个芳族和 或/或杂环，任选取代的环，或其中取代基是氨基甲酸酯基团，其氨基甲酰基代表含有一个或多个任选取代的具有2-36个碳原子的碳链，或含至少一个芳族的基团 和/或杂环，任选取代的环。 还公开了由取代改性纤维素制成的透析膜，通常为扁平薄膜，管状薄膜或中空丝。
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公开(公告)号：US5132415A
公开(公告)日：1992-07-21
申请号：US578575
申请日：1990-09-07
摘要： Method of manufacturing deoxycellulose compounds from cellulose in aprotic solvents with LiCl and/or CaCl.sub.2, with the solvent, in addition to LiCl or CaCl.sub.2, additionally containing bromides, iodides, rhodanides, or dithiocarbamates of the alkaline and/or alkaline earth metals, and the cellulose initially being dissolved in the mixture of aprotic solvent and salts, with a base and/or a basic salt being added at room temperature, and a sulfonic acid halide being added corresponding to the desired degree of substitution, and then being caused to react at temperatures between 16.degree. C. and 100.degree. C.
摘要翻译： 使用LiCl和/或CaCl 2的非质子溶剂中的纤维素制备脱氧纤维素化合物的方法，除了LiCl或CaCl 2之外还含有碱金属和/或碱土金属的溴化物，碘化物，硫氰酸盐或二硫代氨基甲酸盐的溶剂，以及 纤维素最初溶解在非质子溶剂和盐的混合物中，在室温下加入碱和/或碱性盐，并加入对应于所需取代度的磺酰卤，然后使其在 温度在16℃到100℃之间
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公开(公告)号：US5008385A
公开(公告)日：1991-04-16
申请号：US219309
申请日：1988-07-15
申请人： Michael Diamantoglou
发明人： Michael Diamantoglou
摘要： Cellulose derivatives are disclosed which have the following formula: ##STR1## wherein Z is selected from the group consisting of alkylene, alkenylene, alkynylene, cycloalkylene or benzylene or xylylene radicals, which may or may not be substituted;X is selected from the group consisting of --H, --NR.sub.2, --N.sup.+ R.sub.3, --CN, --COOH, --SO.sub.3 H, --SO.sub.3 H, --PO(OR).sub.2, CONR.sub.2 or --Si(OR).sub.3 ;R is selected from the group consisting of hydrogen, alkyl and alkenyl groups having from 1 to 25 carbon atoms, and cycloalkyl, tolyl and phenyl groups;Y is selected from the group consisting of alkyl, alkenyl, alkynyl groups having from 1 to 36 carbon atoms, which may or may not be substituted, cycloalkyl, phenyl, tolyl and benzyl groups, ##STR2## (--CH.dbd.CH--COOH), and NHR, where R has the same meaning as in X, andm=0 to 2.5n=0.01 to 2.95,with the provision that, when m=0, n.gtoreq.1.55, if Y is an alkyl radical with 1 to 5 carbon atoms, 3-(CH.sub.2).sub.r radical with r-0, 1 or 2 or a phthalic acid radical,and also the degree of polymerization being higher than 400. These cellulose derivatives can be synthesized by homogeneous reaction in a mixture of dimethylacetamide and/or N-methylpyrrolidone with LiCl, preferably after activation of the cellulose starting material in the absence of LiCl. These cellulose derivatives are suitable for use as membranes and fibers, especially in hemodialysis applications.
摘要翻译： 公开了具有下式的纤维素衍生物：其中Z选自亚烷基，亚烯基，亚炔基，亚环烷基或亚苯基或亚二甲苯基，其可以被取代或不被取代; X选自-H，-NR2，-N + R3，-CN，-COOH，-SO3H，-SO3H，-PO（OR）2，CONR2或-Si（OR）3; R选自氢，具有1至25个碳原子的烷基和烯基，以及环烷基，甲苯基和苯基; Y选自烷基，烯基，具有1至36个碳原子的炔基，其可以是或可以不被取代，环烷基，苯基，甲苯基和苄基，（-CH = CH -COOH）和NHR，其中R具有与X相同的含义，m = 0至2.5 n = 0.01至2.95，条件是当m = 0时，n> = 1.55，如果Y是烷基 具有1至5个碳原子的基团，3-（CH 2）r基团与r-0,1或2或邻苯二甲酸基团，并且聚合度高于400.这些纤维素衍生物可以通过均相反应 二甲基乙酰胺和/或N-甲基吡咯烷酮与LiCl的混合物，优选在不存在LiCl的情况下活化纤维素原料之后。 这些纤维素衍生物适用于膜和纤维，特别是在血液透析应用中。
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