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公开(公告)号：US09339643B1
公开(公告)日：2016-05-17
申请号：US11694769
申请日：2007-03-30
CPC分类号： A61N1/0553 , A61N1/0476 , A61N1/05 , A61N1/375
摘要： An implantable device for stimulating body tissue that includes an electrode lead body and at least one stimulating electrode contact disposed on the electrode lead body. The electrode lead body may be a percutaneous electrode lead or an electrode paddle that is configured and arranged to be substantially stiff outside the patient's body and during insertion into the patient's body and then becomes non-stiff within the patient's body. The stiffness may be modified using, for example, resorbable materials, temperature sensitive materials, or a lumen within the lead body for introducing a pressurized gas or liquid to modify a stiffness of the lead body. In one embodiment, the lead body may have different acute and/or chronic shapes.
摘要翻译： 一种用于刺激身体组织的可植入装置，包括电极引线体和设置在电极引线体上的至少一个刺激电极触点。 电极引线体可以是经皮电极引线或电极焊盘，其被构造和布置成在插入到患者体内并且然后在患者身体内变得非刚性时基本上刚性地在患者身体外部僵硬。 可以使用例如可吸收材料，温度敏感材料或引线体内的管腔来引入加压气体或液体以改变引线体的刚度来改变刚度。 在一个实施例中，引线体可具有不同的急性和/或慢性形状。
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公开(公告)号：US20130013044A1
公开(公告)日：2013-01-10
申请号：US13620138
申请日：2012-09-14
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US07856277B1
公开(公告)日：2010-12-21
申请号：US11464137
申请日：2006-08-11
IPC分类号： A61N1/372
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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4.发明授权Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权基于植入式酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US06934572B2
公开(公告)日：2005-08-23
申请号：US10286174
申请日：2002-10-31
IPC分类号： A61B5/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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公开(公告)号：US08554342B2
公开(公告)日：2013-10-08
申请号：US13620138
申请日：2012-09-14
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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6.发明授权Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces 有权基于植入式酶的监测系统由于改进的外表面而具有改善的寿命公开(公告)号：US07722913B2
公开(公告)日：2010-05-25
申请号：US11096818
申请日：2005-03-31
IPC分类号： A61L33/00
CPC分类号： A61B5/14865 , A61B5/14532
摘要： An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
摘要翻译： 提供了一种适用于长期体内使用的可植入酶的监测系统，用于测量规定物质如葡萄糖的浓度。 在一个实施方案中，可植入酶基监测系统包括至少一个传感器组件，围绕传感器组件的外部膜并且在其中具有窗口，以及固定到外部膜并覆盖窗户的聚合物窗口盖。 优选地，监测系统的外膜是硅树脂，窗罩是甲基丙烯酸2-羟乙酯（HEMA），甲基丙烯酸N，N，N-二甲基氨基乙酯（DMAEMA）和甲基丙烯酸（MA）的聚合物。 本文还提供了一种植入式酶基监测系统，其具有至少一个传感器组件，围绕传感器组件的外膜和固定到外膜外表面的涂层，其中该涂层抗凝血和蛋白质结合到外部 外膜表面。 优选地，涂层是80:20摩尔比的聚乙二醇（PEG）和肝素。 最后，本文提供了一种涂覆可植入酶基监测系统的外膜的外表面的方法，包括以下步骤：通过等离子体蚀刻在硅氧烷表面上形成羟基; 使硅氧烷表面与氨基官能化硅烷反应，从而在硅氧烷表面上形成氨基; 同时将聚乙二醇（PEG）和肝素共价结合到氨基上; 并将肝素离子结合到监测系统表面。
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公开(公告)号：US07099718B1
公开(公告)日：2006-08-29
申请号：US10155146
申请日：2002-05-24
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. The pressure of the balloon is monitored or otherwise controlled during the filling process in order to determine at what point the filling process should be discontinued. An elastic aspect of the balloon serves as a contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 气球可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 在填充过程中监测或以其他方式控制气囊的压力，以便确定在何时应该停止填充过程。 气囊的弹性方面用作包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US4707523A
公开(公告)日：1987-11-17
申请号：US786649
申请日：1985-10-11
摘要： Metal oxide containing polymers and particularly styrene, acrylic or protein polymers containing fine, magnetic iron oxide particles are formed by combining a NO.sub.2 -substituted polymer with an acid such as hydrochloric acid in the presence of metal, particularly iron particles. The iron is oxidized to fine, black Fe.sub.3 O.sub.4 particles which deposit selectively on the polymer particles. Nitrated polymers are formed by reacting functionally substituted, nitrated organic compounds such as trinitrobenzene sulfonate or dinitrofluoro benzene with a functionally coreactive polymer such as an amine modified acrylic polymer or a protein. Other transition metals such as cobalt can also be incorporated into polymers using this method.
摘要翻译： 含有金属氧化物的聚合物，特别是含有细的磁性氧化铁颗粒的苯乙烯，丙烯酸或蛋白质聚合物通过在金属，特别是铁颗粒的存在下将NO 2取代的聚合物与酸如盐酸结合而形成。 铁被氧化成精细的黑色Fe 3 O 4颗粒，其选择性沉积在聚合物颗粒上。 硝化聚合物通过功能取代的硝化有机化合物如三硝基苯磺酸盐或二硝基氟苯与功能性聚集体如胺改性丙烯酸聚合物或蛋白质反应而形成。 也可以使用这种方法将其它过渡金属如钴还原成聚合物。
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公开(公告)号：US08295945B1
公开(公告)日：2012-10-23
申请号：US11464109
申请日：2006-08-11
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61M25/1002 , A61M25/1011
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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公开(公告)号：US07983766B1
公开(公告)日：2011-07-19
申请号：US11464128
申请日：2006-08-11
IPC分类号： A61N1/00
CPC分类号： A61N1/0558 , A61M25/10
摘要： An implantable lead having at least one electrode contact at or near its distal end prevents undesirable movement of the electrode contact from its initial implant location. One embodiment relates to a spinal cord stimulation (SCS) lead. A first injectable material is injected into the dura space to mechanically position the electrode array with respect to the spinal cord. Conjunctively for use with adhesives, or alternatively for use instead of the adhesives, a balloon may be positioned on the electrode lead array. The balloon is filled with air, liquid or a compliant material. When inflated, the balloon stabilizes the lead with respect to the spinal cord and holds the lead in place. An elastic aspect of the balloon serves as an internal contained relief valve to limit the pressure the balloon may place on the surrounding tissues when the epidural space is constrained.
摘要翻译： 具有在其远端处或其远端处具有至少一个电极接触的可植入引线防止电极接触件从其初始植入位置的不期望的移动。 一个实施方案涉及脊髓刺激（SCS）引线。 将第一可注射材料注入硬脑膜空间以相对于脊髓机械地定位电极阵列。 结合使用粘合剂，或代替粘合剂代替使用，球囊可以位于电极引线阵列上。 气球充满空气，液体或柔顺材料。 当膨胀时，气囊相对于脊髓稳定铅，并将铅保持在适当位置。 气囊的弹性方面用作内部包含的安全阀，以限制当硬膜外腔被约束时球囊可能在周围组织上的压力。
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