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公开(公告)号：US4230724A
公开(公告)日：1980-10-28
申请号：US57608
申请日：1979-07-16
CPC分类号： A61K31/19 , Y10S514/912
摘要： A method of treating vascularization of the eye as a result of traumatic injury, surgery, such as, corneal transplant, or onset of diabetic retinopathy by topically treating the eye with Flurbiprofen or a pharmaceutically acceptable salt thereof.
摘要翻译： 通过用氟比洛芬或其药学上可接受的盐局部治疗眼睛来治疗由于创伤性损伤，手术（例如角膜移植）或糖尿病性视网膜病变发作引起的眼睛血管化的方法。
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2.发明授权
公开(公告)号：US5330689A
公开(公告)日：1994-07-19
申请号：US39941
申请日：1993-03-29
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
IPC分类号： A61K9/127 , A61K9/133 , A61K31/355
CPC分类号： A61K9/1272 , A61K31/355 , A61K9/1277 , Y10S436/829 , Y10S514/885 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
摘要翻译： 描述了用于制备α-生育酚囊泡的方法和组合物，其双层包含α-生育酚的有机酸衍生物的盐形式，例如α-生育酚半琥珀酸盐的三盐盐形式。 该方法快速有效，不需要使用有机溶剂。 α-生育酚囊泡可用于捕获不溶于水溶液的化合物。 这种制剂对于捕获有限溶解度的生物活性剂特别有用，因此能够在体内施用。
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公开(公告)号：US5234634A
公开(公告)日：1993-08-10
申请号：US599290
申请日：1990-10-17
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini
IPC分类号： A61K9/127 , A61K9/133 , A61K31/355
CPC分类号： A61K9/1272 , A61K31/355 , A61K9/1277 , Y10S436/829 , Y10S514/885 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
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公开(公告)号：US5041278A
公开(公告)日：1991-08-20
申请号：US280551
申请日：1988-12-06
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini
IPC分类号： A61K9/127 , A61K9/133 , A61K31/355
CPC分类号： A61K9/1272 , A61K31/355 , A61K9/1277 , Y10S436/829 , Y10S514/885 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
摘要翻译： 描述了用于制备α-生育酚囊泡的方法和组合物，其双层包含α-生育酚的有机酸衍生物的盐形式，例如α-生育酚半琥珀酸盐的三盐盐形式。 该方法快速有效，不需要使用有机溶剂。 α-生育酚囊泡可用于捕获不溶于水溶液的化合物。 这种制剂对于捕获有限溶解度的生物活性剂特别有用，因此能够在体内施用。
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5.发明授权
公开(公告)号：US5597560A
公开(公告)日：1997-01-28
申请号：US419387
申请日：1995-04-10
CPC分类号： A61K9/0048 , A61K31/70 , Y10S514/912 , Y10S514/914
摘要： This invention includes a pharmaceutically acceptable formulation of Diclofenac, Tobramycin, a solubility agent and, optionally, excipients, tonicifiers, buffers, viscosity modifying agents, preservatives, and chelating agents, at a pH from greater than 7.0 to about 9. The invention also discloses the use of this pharmaceutically acceptable formulation of an antibiotic and NSAIDs to treat eye and ear conditions accompanied by infection and inflammation.
摘要翻译： 本发明包括在大于7.0至约9的pH下的双氯芬酸，妥布霉素，溶解剂和任选的赋形剂，增香剂，缓冲剂，粘度调节剂，防腐剂和螯合剂的药学上可接受的制剂。本发明还公开 使用这种药学上可接受的抗生素和NSAID制剂来治疗伴有感染和炎症的眼睛和耳朵病症。
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6.发明授权Composition using salt form of organic acid derivative of alpha-tocopheral 失效使用盐形式的α-生育酚的有机酸衍生物的组合物
公开(公告)号：US4861580A
公开(公告)日：1989-08-29
申请号：US911138
申请日：1986-09-24
申请人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
发明人： Andrew S. Janoff , Lois E. Bolcsak , Alan L. Weiner , Paul A. Tremblay , Michael V. W. Bergamini , Robert L. Suddith
IPC分类号： A61K9/127 , A61K31/355 , A61K38/00 , A61K45/00 , A61K47/22 , A61K47/28 , A61P25/00 , A61P25/04 , A61P27/02 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/10 , A61P37/06
CPC分类号： A61K9/1277 , A61K31/355 , A61K9/1272 , Y10S436/829 , Y10S514/913 , Y10T428/2984
摘要： Methods and compositions are described for the preparation of alpha-tocopherol vesicles, the bilayers of which comprise a salt form of an organic acid derivative of alpha-tocopherol such as the Tris salt form of alpha-tocopherol hemisuccinate. The method is rapid and efficient and does not require the use of organic solvents. The alpha-tocopherol vesicles may be used to entrap compounds which are insoluble in aqueous solutions. Such preparations are especially useful for entrapping bioactive agents of limited solubility, thus enabling administration in vivo.
摘要翻译： 描述了用于制备α-生育酚囊泡的方法和组合物，其双层包含α-生育酚的有机酸衍生物的盐形式，例如α-生育酚半琥珀酸盐的三盐盐形式。 该方法快速有效，不需要使用有机溶剂。 α-生育酚囊泡可用于捕获不溶于水溶液的化合物。 这种制剂对于捕获有限溶解度的生物活性剂特别有用，因此能够在体内施用。
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