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公开(公告)号：US20140220083A1
公开(公告)日：2014-08-07
申请号：US14130886
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
摘要翻译： 本发明一般涉及含有高浓度阳离子脂质并具有确定的油脂比例的阳离子水包油乳剂。 阳离子脂质可以与带负电荷的分子相互作用，从而将分子固定在乳液颗粒上。 本文所述的阳离子乳液可用于将带负电荷的分子（例如核酸分子）递送至细胞，以及配制基于核酸的疫苗。
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公开(公告)号：US20140212498A1
公开(公告)日：2014-07-31
申请号：US14130880
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K31/713
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
摘要翻译： 本发明一般涉及可用于递送核酸分子（例如RNA分子）的阳离子水包油乳液。 乳剂颗粒包含油芯和阳离子脂质。 乳剂颗粒的平均直径为约80nm至约180nm，乳液的N / P比至少为1.1:1。
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公开(公告)号：US09655845B2
公开(公告)日：2017-05-23
申请号：US14130880
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K31/713 , A61K39/155 , A61K39/12 , A61K9/00 , A61K39/00
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
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公开(公告)号：USD871714S1
公开(公告)日：2019-12-31
申请号：US29612748
申请日：2017-08-03
申请人： Michelle Chan
设计人： Michelle Chan
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5.发明授权Methods, systems and computer program products for monitoring performance of a modem during a connection 失效用于在连接期间监视调制解调器的性能的方法，系统和计算机程序产品公开(公告)号：US06823004B1
公开(公告)日：2004-11-23
申请号：US09430097
申请日：1999-10-29
申请人： Youssef Abdelilah , Gordon Taylor Davis , Jeffrey Haskell Derby , Ajay Dholakia , Michelle Chan Granholm , Dongming Hwang , Fredy D. Neeser , Robert John Schule , Malcolm Scott Ware , Hua Ye , Charles Robert Young
发明人： Youssef Abdelilah , Gordon Taylor Davis , Jeffrey Haskell Derby , Ajay Dholakia , Michelle Chan Granholm , Dongming Hwang , Fredy D. Neeser , Robert John Schule , Malcolm Scott Ware , Hua Ye , Charles Robert Young
IPC分类号： H04B138
CPC分类号： G06F11/3485 , H04M11/066 , H04W24/00 , H04W48/16 , H04W76/10
摘要： Methods, systems and computer program products are provided for monitoring performance of a modem which obtain diagnostic data directly from memory associated with the modem's digital signal processor (DSP). A secondary path to the DSP memory is utilized for the monitoring operations so that real time data can be obtained during connection startup procedures and during an active connection. First-in first-out (FIFO) buffers are incorporated in the DSP memory to track state transitions of one or more of the state machines within the modem and various performance data measurements may be obtained directly from the DSP memory responsive to different state transition events. The real time collected data may be stored in a file and provided to a remote location for use in diagnosing customer problems with specific customer line connections. Accordingly, real time monitoring of digital and analog line conditions and modem performance may be utilized to diagnose problems with modems and line connections.
摘要翻译： 提供了方法，系统和计算机程序产品，用于监视直接从与调制解调器的数字信号处理器（DSP）相关联的存储器获取诊断数据的调制解调器的性能。 利用DSP存储器的辅助路径进行监视操作，以便在连接启动过程期间和在主动连接期间可以获得实时数据。 先进先出（FIFO）缓冲器被并入DSP存储器中以跟踪调制解调器内的一个或多个状态机的状态转换，并且可以响应于不同的状态转换事件从DSP存储器直接获得各种性能数据测量 。 实时收集的数据可以存储在文件中并提供给远程位置以用于诊断具有特定客户线路连接的客户问题。 因此，可以利用数字和模拟线路条件和调制解调器性能的实时监测来诊断调制解调器和线路连接的问题。
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公开(公告)号：US09636410B2
公开(公告)日：2017-05-02
申请号：US14130886
申请日：2012-07-06
申请人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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