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公开(公告)号:US07998987B2
公开(公告)日:2011-08-16
申请号:US12756301
申请日:2010-04-08
申请人: David Lauffer , Alex Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
发明人: David Lauffer , Alex Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
IPC分类号: C07D513/04 , A61K31/433
CPC分类号: C07D498/04 , C07D487/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US20070191369A1
公开(公告)日:2007-08-16
申请号:US11606524
申请日:2006-11-30
申请人: David Lauffer , Alexander Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
发明人: David Lauffer , Alexander Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
IPC分类号: A61K31/53 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/4439 , A61K31/433 , C07D498/04
CPC分类号: C07D498/04 , C07D487/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US20100144739A1
公开(公告)日:2010-06-10
申请号:US12441187
申请日:2007-09-18
申请人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
发明人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
IPC分类号: A61K31/5025 , C07D487/04 , C12N9/99 , C07D409/14 , A61K31/497 , A61P35/00
CPC分类号: C07D497/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US08481538B2
公开(公告)日:2013-07-09
申请号:US12441187
申请日:2007-09-18
申请人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
发明人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
IPC分类号: A61K31/5025 , C07D487/04 , A61P35/00 , A61P9/10
CPC分类号: C07D497/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US20070254868A1
公开(公告)日:2007-11-01
申请号:US11726170
申请日:2007-03-21
申请人: David Lauffer , Robert Davies , Dean Stamos , Alexander Aronov , David Deininger , Ronald Grey , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Bethiel , Dylan Jacobs , Kira McGinty
发明人: David Lauffer , Robert Davies , Dean Stamos , Alexander Aronov , David Deininger , Ronald Grey , Jinwang Xu , Pan Li , Brian Ledford , Luc Farmer , Randy Bethiel , Dylan Jacobs , Kira McGinty
IPC分类号: A61K31/4439 , A61K31/437 , A61K31/454 , A61K31/55 , C07D213/82 , C07D401/04 , C07D471/04 , C12N9/99 , C07D403/14 , C07D223/00 , A61P35/00 , A61K31/497 , A61K31/44
CPC分类号: C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D451/02 , C07D451/06 , C07D453/02 , C07D471/04 , C07D471/08 , C07D495/04 , C07D498/08 , C07D513/04 , C12N9/99
摘要: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides processes for preparing the compounds of this invention, pharmaceutically acceptable compositions comprising the compounds of the invention, and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供了制备本发明化合物的方法,包含本发明化合物的药学上可接受的组合物,以及使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20120010222A1
公开(公告)日:2012-01-12
申请号:US13234634
申请日:2011-09-16
申请人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
发明人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud Le Tiran , Joseph Drumm
IPC分类号: A61K31/506 , A61K31/4184 , A61P31/04 , A61K31/4439
CPC分类号: C07D413/14 , A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译: 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗,预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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公开(公告)号:US08394803B2
公开(公告)日:2013-03-12
申请号:US11593418
申请日:2006-11-06
申请人: Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
发明人: Paul Charifson , David Deininger , Joseph Drumm , Anne-Laure Grillot , Arnaud LeTiran , Yusheng Liao , Emanuele Perola , Steven Ronkin , Dean Stamos , Tiansheng Wang
IPC分类号: A61K31/4184 , A61K31/4427 , A61K31/496 , A61K31/4155 , C07D235/04 , C07D403/02 , C07D403/14 , C07D401/02 , C07D401/14
CPC分类号: C07D403/04 , C07D401/04 , C07D403/14
摘要: The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译: 本发明涉及抑制细菌回旋酶和/或Topo IV的式I化合物或其药学上可接受的盐以及包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此,本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号:US20090325935A1
公开(公告)日:2009-12-31
申请号:US12478372
申请日:2009-06-04
申请人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号: A61K31/551 , C07D401/14 , A61K31/444 , A61K31/5377 , C07D413/14 , C12N9/99
CPC分类号: C07D403/04 , C07D401/14 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
摘要翻译: 本发明涉及抑制细菌回旋酶和/或Topo IV的化合物和包含所述化合物的药学上可接受的组合物。 这些化合物及其组合物可用于治疗细菌感染。 因此,本发明还涉及用于治疗哺乳动物细菌感染的方法。
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公开(公告)号:US20060025424A1
公开(公告)日:2006-02-02
申请号:US10971573
申请日:2004-10-21
申请人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号: A61K31/506 , C07D403/14
CPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to compounds that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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公开(公告)号:US20050256136A1
公开(公告)日:2005-11-17
申请号:US10986569
申请日:2004-11-11
申请人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
发明人: Paul Charifson , David Deininger , Anne-Laure Grillot , Yusheng Liao , Steven Ronkin , Dean Stamos , Emanuele Perola , Tiansheng Wang , Arnaud LeTiran , Joseph Drumm
IPC分类号: A61K31/4439 , A61K31/506 , A61P31/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
CPC分类号: A61K31/4439 , A61K31/506 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要: The present invention relates to methods of treating, preventing, or lessening the severity of resistant bacterial infections in mammals, utilizing compounds of formula I or formula VII or pharmaceutically salts thereof. The present invention also relates to methods of using compounds of formula I or formula VII in combination with one or more additional antibacterial agents and/or one or more additional therapeutic agents that increase the susceptibility of bacterial organisms to antibiotics.
摘要翻译: 本发明涉及使用式I或式VII化合物或其药学上可接受的方法治疗,预防或减轻哺乳动物中抗性细菌感染的严重性。 本发明还涉及使用式I或式VII化合物与一种或多种另外的抗菌剂和/或一种或多种增加细菌生物体对抗生素敏感性的其它治疗剂的组合的方法。
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