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公开(公告)号:US20070191369A1
公开(公告)日:2007-08-16
申请号:US11606524
申请日:2006-11-30
申请人: David Lauffer , Alexander Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
发明人: David Lauffer , Alexander Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
IPC分类号: A61K31/53 , A61K31/497 , A61K31/506 , A61K31/501 , A61K31/4439 , A61K31/433 , C07D498/04
CPC分类号: C07D498/04 , C07D487/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US20100144739A1
公开(公告)日:2010-06-10
申请号:US12441187
申请日:2007-09-18
申请人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
发明人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
IPC分类号: A61K31/5025 , C07D487/04 , C12N9/99 , C07D409/14 , A61K31/497 , A61P35/00
CPC分类号: C07D497/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US08481538B2
公开(公告)日:2013-07-09
申请号:US12441187
申请日:2007-09-18
申请人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
发明人: Alexander Aronov , Jon Come , John Court , David Deininger , David Lauffer , Pan Li , Kira McGinty , Suganthini Nanthakumar , Dean Stamos , Kirk Tanner
IPC分类号: A61K31/5025 , C07D487/04 , A61P35/00 , A61P9/10
CPC分类号: C07D497/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US07998987B2
公开(公告)日:2011-08-16
申请号:US12756301
申请日:2010-04-08
申请人: David Lauffer , Alex Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
发明人: David Lauffer , Alex Aronov , Pan Li , David Deininger , Kira McGinty , Dean Stamos , Jon Come , Michelle Stewart
IPC分类号: C07D513/04 , A61K31/433
CPC分类号: C07D498/04 , C07D487/04 , C07D513/04
摘要: The present invention provides compounds useful as inhibitors of c-Met tyrosine kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various proliferative disorders.
摘要翻译: 本发明提供了可用作c-Met酪氨酸激酶抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种增殖性疾病的方法。
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公开(公告)号:US20060135537A1
公开(公告)日:2006-06-22
申请号:US11266935
申请日:2005-11-04
申请人: Ronald Knegtel , Juan-Miguel Jimenez , Jean-Damien Charrier , Dean Stamos , Pan Li , Jon Come , Alex Aronov
发明人: Ronald Knegtel , Juan-Miguel Jimenez , Jean-Damien Charrier , Dean Stamos , Pan Li , Jon Come , Alex Aronov
IPC分类号: A61K31/519 , C07D487/04 , C07F9/6512 , A61K31/675
CPC分类号: C07D487/04 , C07F9/6561
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
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6.
公开(公告)号:US07528138B2
公开(公告)日:2009-05-05
申请号:US11266935
申请日:2005-11-04
申请人: Ronald Knegtel , Juan-Miguel Jimenez , Jean-Damien Charrier , Dean Stamos , Pan Li , Jon Come , Alex Aronov
发明人: Ronald Knegtel , Juan-Miguel Jimenez , Jean-Damien Charrier , Dean Stamos , Pan Li , Jon Come , Alex Aronov
IPC分类号: C07D487/04 , A61K31/519 , A61P35/00
CPC分类号: C07D487/04 , C07F9/6561
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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7.
公开(公告)号:US08188281B2
公开(公告)日:2012-05-29
申请号:US12273799
申请日:2008-11-19
申请人: Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人: Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号: C07D471/02
CPC分类号: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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8.
公开(公告)号:US07507826B2
公开(公告)日:2009-03-24
申请号:US11093821
申请日:2005-03-30
申请人: Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
发明人: Francesco Salituro , Luc Farmer , Randy Bethiel , Edmund Harrington , Jeremy Green , John Court , Jon Come , David Lauffer , Alex Aronov , Hayley Binch , Dean Boyall , Jean-Damien Charrier , Simon Everitt , Damien Fraysse , Michael Mortimore , Francoise Pierard , Daniel Robinson , Jian Wang , Joanne Pinder , Tiansheng Wang , Albert Pierce
IPC分类号: C07D471/02
CPC分类号: C07D471/04 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/695 , A61K45/06 , C07D519/00 , C07F7/0805
摘要: The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08937064B2
公开(公告)日:2015-01-20
申请号:US12817785
申请日:2010-06-17
申请人: Mark Ledeboer , Valerie Marone , Michelle Stewart , David Messersmith , John Duffy , Gabriel Martinez Botella , Jon Come , Huai Gao , Albert Pierce , Francesco Salituro
发明人: Mark Ledeboer , Valerie Marone , Michelle Stewart , David Messersmith , John Duffy , Gabriel Martinez Botella , Jon Come , Huai Gao , Albert Pierce , Francesco Salituro
IPC分类号: A61K31/535 , C07D415/00 , C07D487/00 , A01N43/90 , C07D487/04
CPC分类号: C07D487/04
摘要: The present invention relates to compounds of formula (I) useful as selective inhibitors of JAK2 kinase. The invention also provides pharmaceutical acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions or disorders. The invention also provides processes for preparing the compounds of the invention.
摘要翻译: 本发明涉及可用作JAK2激酶选择性抑制剂的式(I)化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US08921376B2
公开(公告)日:2014-12-30
申请号:US11438748
申请日:2006-05-22
申请人: Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人: Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号: C07D471/04 , A61K31/437 , C07D487/04
CPC分类号: C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂,特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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