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公开(公告)号：US07888531B2
公开(公告)日：2011-02-15
申请号：US12485156
申请日：2009-06-16
IPC分类号： C07C229/00 , C07C51/15
CPC分类号： C07C233/63 , C07C2601/14
摘要： Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble.
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公开(公告)号：US07586001B2
公开(公告)日：2009-09-08
申请号：US12098118
申请日：2008-04-04
IPC分类号： C07C229/00 , C07C51/15
CPC分类号： C07C233/63 , C07C2601/14
摘要： New nateglinide crystals, i. e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4°, 5.2°, 15.7°, 18.5° (2θ)), M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) and P-type crystals (main peaks in powder X-ray diffraction: 4.8°, 5.3°, 14.3°, 15.2° (2θ)), can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble or, alternatively, by dissolving nateglinide in a mixed solvent composed of a solvent in which nateglinide is highly soluble and another solvent in which it is difficultly soluble, cooling the nateglinide solution to form crystals, filtering the mixture and drying the crystals at a specified temperature.
摘要翻译： 新奈格列奈晶体， e。 那格列奈A型晶体（粉末X射线衍射中的主峰：4.4°，5.2°，15.7°，18.5°（2θ）），M型晶体（粉末X射线衍射中的主峰：6.0°，14.2° ，15.2°，18.8°（2θ））和P型晶体（粉末X射线衍射中的主峰：4.8°，5.3°，14.3°，15.2°（2θ））可以通过将那格列奈溶解在溶剂中 其中那格列奈高度可溶，然后加入那格列奈难以溶解的溶剂，或者通过将那格列奈溶解在由那格列奈高度溶解的溶剂和难溶于其中的溶剂组成的混合溶剂中，冷却 那格列奈溶液形成晶体，过滤混合物并在特定温度下干燥晶体。
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公开(公告)号：US20070232829A1
公开(公告)日：2007-10-04
申请号：US11757769
申请日：2007-06-04
IPC分类号： C07C229/36
CPC分类号： C07C231/24 , C07C2601/14 , C07C233/63
摘要： A method for producing B-type crystals of nateglinide substantially free of H-type crystals is provided, which comprises drying solvated wet crystals of nateglinide at a low temperature until no solvent remains and making a crystal conversion thereof. According to this method, B-type crystals of nateglinide can be produced at an industrial scale without allowing other forms of the crystalline polymorphism to coexist.
摘要翻译： 提供了一种生产基本上不含H型晶体的那格列奈B型晶体的方法，其包括在低温下干燥那格列奈的溶剂化湿的晶体，直到没有溶剂残留并进行晶体转化。 根据该方法，可以在工业规模下生产那格列奈的B型晶体，而不允许其他形式的结晶多晶型共存。
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公开(公告)号：US20060155143A1
公开(公告)日：2006-07-13
申请号：US11319177
申请日：2005-12-28
申请人： Michito Sumikawa , Takao Ohgane
发明人： Michito Sumikawa , Takao Ohgane
IPC分类号： C07C231/02
CPC分类号： C07D213/82 , C07C231/02 , C07C2601/14 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/63 , C07C233/87 , C07C235/60
摘要： There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under the alkali condition by using potassium hydroxide.
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公开(公告)号：US07030268B2
公开(公告)日：2006-04-18
申请号：US10418102
申请日：2003-04-18
申请人： Michito Sumikawa , Takao Ohgane
发明人： Michito Sumikawa , Takao Ohgane
IPC分类号： C07C229/34 , C07C229/02
CPC分类号： C07D213/82 , C07C231/02 , C07C2601/14 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/63 , C07C233/87 , C07C235/60
摘要： There is provided a method for producing easily highly-purified acylphenylalanine that is useful as a raw material of pharmaceutical products and the like, which comprises the step of reacting an acid chloride with phenylalanine in a mixed solvent of an organic solvent and water, while keeping the solvent under the alkali condition by using potassium hydroxide.
摘要翻译： 本发明提供一种易于高纯化的酰基苯丙氨酸的制造方法，其可用作药物等的原料，其包括使酰氯与苯丙氨酸在有机溶剂和水的混合溶剂中反应的步骤，同时保持 溶剂在碱性条件下使用氢氧化钾。
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公开(公告)号：US20050101672A1
公开(公告)日：2005-05-12
申请号：US10965171
申请日：2004-10-15
IPC分类号： A61K31/198 , C07C233/63 , C07C233/76
CPC分类号： C07C233/63 , C07C2601/14
摘要： New nateglinide crystals, i.e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4°, 5.2°, 15.7°, 18.5°(2θ)), M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8°(2θ)) and P-type crystals (main peaks in powder X-ray diffraction: 4.8°, 5.3°, 14.3°, 15.2°(2θ)), can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble or, alternatively, by dissolving nateglinide in a mixed solvent composed of a solvent in which nateglinide is highly soluble and another solvent in which it is difficultly soluble, cooling the nateglinide solution to form crystals, filtering the mixture and drying the crystals at a specified temperature.
摘要翻译： 新那格列奈晶体，即那格列奈A型晶体（粉末X射线衍射中的主峰：4.4°，5.2°，15.7°，18.5°（2θ）），M型晶体（粉末X射线衍射中的主峰： 6.0°，14.2°，15.2°，18.8°（2θ））和P型晶体（粉末X射线衍射中的主峰：4.8°，5.3°，14.3°，15.2°（2θ））可以通过 将那格列奈溶解在那格列奈高度溶解的溶剂中，然后加入那格列奈难以溶解的溶剂，或者通过将那格列奈溶解在由那格列奈高度溶解的溶剂和其中所述的其他溶剂组成的混合溶剂中 难以溶解，冷却那格列奈溶液形成晶体，过滤混合物并在特定温度下干燥晶体。
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7.发明授权Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and methods for preparing them 失效N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的晶体及其制备方法
公开(公告)号：US5488150A
公开(公告)日：1996-01-30
申请号：US166144
申请日：1993-12-14
IPC分类号： C07C231/24 , A61K31/13 , A61K31/195 , C07C211/43 , C07C231/22 , C07C233/63 , C07C239/00
CPC分类号： C07C231/22 , C07C233/63
摘要： Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, eg. stability to grinding.
摘要翻译： N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的稳定晶体可以通过在至少10℃的温度下用溶剂处理该化合物并在溶剂中在至少10℃的温度下形成晶体来制备 例如，可以通过从溶液中结晶而形成晶体，或者可以由悬浮在溶剂中的化合物的固体颗粒形成晶体。 以这种方式形成的晶体具有来自先前已知形式的化合物的不同的熔点，红外光谱和X射线衍射图，并具有增强的可加工性，例如。 稳定磨削。
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公开(公告)号：US09029333B2
公开(公告)日：2015-05-12
申请号：US12625396
申请日：2009-11-24
IPC分类号： A61K31/7004 , A61P13/12 , A61K31/194 , A61K33/14
CPC分类号： A61K31/194 , A61K31/7004 , A61K33/14 , A61K2300/00
摘要： The present invention provides a glucose decomposition-suppressed solid preparation for dialysis among powdery or granular preparations for dialysis containing acetate-free solid organic acids as pH adjusting agents. The present invention provides the solid preparation for dialysis containing electrolytes, glucose and pH adjusting agents characterized in that solid organic acids containing reduced amount of microparticles are used, and more specifically, characterized in that solid organic acids whose 20 or less percent of particles are 250 μm or less in diameter, or solid organic acids whose 10 or less percent of particles are 150 μm or less in diameter, are used. Preferably, the solid organic acid contained therein is citric acid.
摘要翻译： 本发明提供了用于透析的葡萄糖分解抑制固体制剂，用于含有无醋酸固体有机酸作为pH调节剂的透析用粉末或颗粒状制剂。 本发明提供了含有电解质，葡萄糖和pH调节剂的透析用固体制剂，其特征在于，使用含有减少量的微粒的固体有机酸，更具体地说，其特征在于，其20％以下的颗粒的固体有机酸为250 或者其直径为10μm以下的颗粒的10％以下的固体有机酸。 其中所含的固体有机酸优选为柠檬酸。
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公开(公告)号：US20090253933A1
公开(公告)日：2009-10-08
申请号：US12485156
申请日：2009-06-16
IPC分类号： C07C229/36
CPC分类号： C07C233/63 , C07C2601/14
摘要： Nateglinide M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble.
摘要翻译： 那格列奈M型晶体（粉末X射线衍射中的主峰：6.0°，14.2°，15.2°，18.8°（2θ））可以通过将那格列奈溶解在那格列奈高度溶解的溶剂中，然后加入溶剂 那格列奈难以溶解。
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公开(公告)号：US20080194867A1
公开(公告)日：2008-08-14
申请号：US12098118
申请日：2008-04-04
IPC分类号： C07C229/28
CPC分类号： C07C233/63 , C07C2601/14
摘要： New nateglinide crystals, i.e. nateglinide A-type crystals (main peaks in powder X-ray diffraction: 4.4°, 5.2°, 15.7°, 18.5° (2θ)), M-type crystals (main peaks in powder X-ray diffraction: 6.0°, 14.2°, 15.2°, 18.8° (2θ)) and P-type crystals (main peaks in powder X-ray diffraction: 4.8°, 5.3°, 14.3°, 15.2° (2θ)), can be produced by dissolving nateglinide in a solvent in which nateglinide is highly soluble and then adding a solvent in which nateglinide is difficultly soluble or, alternatively, by dissolving nateglinide in a mixed solvent composed of a solvent in which nateglinide is highly soluble and another solvent in which it is difficultly soluble, cooling the nateglinide solution to form crystals, filtering the mixture and drying the crystals at a specified temperature.
摘要翻译： 新那格列奈晶体，即那格列奈A型晶体（粉末X射线衍射中的主峰：4.4°，5.2°，15.7°，18.5°（2θ）），M型结晶（粉末X射线衍射中的主峰： 6.0°，14.2°，15.2°，18.8°（2θ））和P型晶体（粉末X射线衍射中的主峰：4.8°，5.3°，14.3°，15.2°（2θ））可以通过 将那格列奈溶解在那格列奈高度溶解的溶剂中，然后加入那格列奈难以溶解的溶剂，或者通过将那格列奈溶解在由那格列奈高度溶解的溶剂和其中所述的其他溶剂组成的混合溶剂中 难以溶解，冷却那格列奈溶液形成晶体，过滤混合物并在特定温度下干燥晶体。
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