利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

30 条记录 (耗时 0.022 秒)

    Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and methods for preparing them
    1.
    发明授权
    Crystals of N-(trans-4-isopropylcyclohexycarbonyl)-D-phenylalanine and methods for preparing them 失效
    N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的晶体及其制备方法

    公开(公告)号：US5488150A

    公开(公告)日：1996-01-30

    申请号：US166144

    申请日：1993-12-14

    申请人： Michito Sumikawa ,  Yoshihito Koguchi ,  Takao Ohgane ,  Yasuo Irie ,  Satoji Takahashi

    发明人： Michito Sumikawa ,  Yoshihito Koguchi ,  Takao Ohgane ,  Yasuo Irie ,  Satoji Takahashi

    IPC分类号： C07C231/24 ,  A61K31/13 ,  A61K31/195 ,  C07C211/43 ,  C07C231/22 ,  C07C233/63 ,  C07C239/00

    CPC分类号： C07C231/22 ,  C07C233/63

    摘要： Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, eg. stability to grinding.

    摘要翻译： N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的稳定晶体可以通过在至少10℃的温度下用溶剂处理该化合物并在溶剂中在至少10℃的温度下形成晶体来制备 例如，可以通过从溶液中结晶而形成晶体，或者可以由悬浮在溶剂中的化合物的固体颗粒形成晶体。 以这种方式形成的晶体具有来自先前已知形式的化合物的不同的熔点，红外光谱和X射线衍射图，并具有增强的可加工性，例如。 稳定磨削。

    Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
    2.
    发明授权
    Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them 失效
    N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的晶体及其制备方法

    公开(公告)号：US5463116A

    公开(公告)日：1995-10-31

    申请号：US190460

    申请日：1994-02-02

    申请人： Michito Sumikawa ,  Yoshihito Koguchi ,  Takao Ohgane ,  Yasuo Irie ,  Satoji Takahashi

    发明人： Michito Sumikawa ,  Yoshihito Koguchi ,  Takao Ohgane ,  Yasuo Irie ,  Satoji Takahashi

    IPC分类号： C07C231/22 ,  C07C233/63 ,  C07C229/00

    CPC分类号： C07C231/22 ,  C07C233/63 ,  C07B2200/13 ,  C07C2101/14

    摘要： Stable crystals of N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine may be produced by treating this compound with a solvent at a temperature of at least 10.degree. C. and forming crystals in the solvent at a temperature of at least 10.degree. C. For example, crystals may be formed by crystallization out of solution, or may be formed from solid particles of the compound suspended in a solvent. Crystals formed in this way have different melting point, infra red spectrum and X-ray diffraction patterns from previously known forms of the compound and have enhanced processability, e.g., stability to grinding.

    摘要翻译： N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸的稳定晶体可以通过在至少10℃的温度下用溶剂处理该化合物并在溶剂中在至少10℃的温度下形成晶体来制备 例如，可以通过从溶液中结晶而形成晶体，或者可以由悬浮在溶剂中的化合物的固体颗粒形成晶体。 以这种方式形成的晶体具有来自先前已知形式的化合物的不同的熔点，红外光谱和X射线衍射图，并且具有增强的加工性，例如研磨的稳定性。

    Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test
    5.
    发明申请
    Method and Composition to Evaluate Cytochrome P450 2D6 Isoenzyme Activity Using a Breath Test 审中-公开
    使用呼吸试验评估细胞色素P450 2D6同工酶活性的方法和组成

    公开(公告)号：US20100329979A1

    公开(公告)日：2010-12-30

    申请号：US12874350

    申请日：2010-09-02

    申请人： Anil S. Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    发明人： Anil S. Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    IPC分类号： A61K51/08

    CPC分类号： C12Q1/26 ,  A61K51/1206

    摘要： The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.

    摘要翻译： 本发明一般涉及通过呼吸测定法确定和评估个体哺乳动物受试者中的细胞色素P450 2D6同工酶（CYP2D6）相关代谢能力的方法，通过确定受试者在静脉内或口服时呼出的13CO2的相对量 施用13C标记的CYP2D6底物化合物。 本发明可用作体内表型测定法，用于使用呼气中的代谢物13CO2评估CYP2D6相关活性，并确定CYP2D6底物化合物的最佳剂量和给药时间。

    Propeller for ship
    7.
    发明授权
    Propeller for ship 失效
    船用螺旋桨

    公开(公告)号：US4514146A

    公开(公告)日：1985-04-30

    申请号：US436988

    申请日：1982-10-22

    申请人： Takeo Nojiri ,  Yasuo Irie

    发明人： Takeo Nojiri ,  Yasuo Irie

    IPC分类号： B63H1/14 ,  B63H1/28 ,  B63H1/20

    CPC分类号： B63H1/28 ,  B63H1/14 ,  B63H2001/145

    摘要： In a propeller for use in a ship of the type comprising 4 or more even number blades, at least one of two adjacent blades is inclined forwardly or rearwardly or one inclined forwardly and the other rearwardly so as to make different the rake angles of the two blades. The pitch angle of the rearwardly inclined blade is made larger than that of the forwardly inclined blade. With this construction the mutual interference between adjacent blades is efficiently utilized to prevent decrease in the efficiency even when operating conditions and the diameter of the propeller vary.

    摘要翻译： 在用于包括4个或更多个偶数叶片的类型的船舶的螺旋桨中，两个相邻叶片中的至少一个叶片向前或向后倾斜，或者向前倾斜并且向后倾斜，以使两者的前角不同 刀片。 使向后倾斜的叶片的俯仰角比前倾叶片的俯仰角大。 利用这种结构，即使在螺旋桨的操作条件和直径变化的情况下，相邻叶片之间的相互干扰也被有效地利用以防止效率降低。

    Coin dispensing apparatus
    8.
    发明授权
    Coin dispensing apparatus 有权
    硬币分配装置

    公开(公告)号：US07445545B2

    公开(公告)日：2008-11-04

    申请号：US11006191

    申请日：2004-12-07

    申请人： Hiroshi Abe ,  Yasuo Irie

    发明人： Hiroshi Abe ,  Yasuo Irie

    IPC分类号： G07D1/00

    CPC分类号： G07D9/008

    摘要： A coin dispensing apparatus is provided that has features to easily adjust the distance between the base plate and the rotating disk and to adapt to the thickness of the coins. The coin dispensing apparatus includes a disk (102) which separates coins one by one. A coin base (104) supports the coins which are moved by the disk. A body (100) includes the base and a step section (149) which provides different distances to the base to adapt to the thickness of the coins. A rotating shaft member (160) is selectively attached to the step section and can be adjusted to the body. The rotating shaft member for rotating the disk is selectively attached at the step section in stages. Therefore the distance between the disk and the base is adjusted to adapt the thickness of coin.

    摘要翻译： 提供了一种硬币分配装置，其具有容易地调整基板和旋转盘之间的距离并适应硬币的厚度的特征。 硬币分配装置包括一个一个地分离硬币的盘（102）。 硬币基座（104）支撑由盘移动的硬币。 主体（100）包括基座和台阶部分（149），其向基座提供不同距离以适应硬币的厚度。 旋转轴构件（160）选择性地附接到台阶部并且可以调节到身体。 用于旋转盘的旋转轴构件分阶段地选择性地附接在台阶部分。 因此，调整盘和基座之间的距离以适应硬币的厚度。

    Method and composition to evaluate cytochrome P450 2D6 isoenzyme activity using a breath test
    9.
    发明申请
    Method and composition to evaluate cytochrome P450 2D6 isoenzyme activity using a breath test 审中-公开
    使用呼吸试验评估细胞色素P450 2D6同工酶活性的方法和组成

    公开(公告)号：US20070026480A1

    公开(公告)日：2007-02-01

    申请号：US11404965

    申请日：2006-04-14

    申请人： Anil Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    发明人： Anil Modak ,  Yasuo Irie ,  Yasuhisa Kurogi

    IPC分类号： C12Q1/26

    CPC分类号： C12Q1/26 ,  A61K51/1206

    摘要： The present invention relates, generally to a method of determining and assessing cytochrome P450 2D6 isoenzyme (CYP2D6)-related metabolic capacity in an individual mammalian subject via a breath assay, by determining the relative amount of 13CO2 exhaled by a the subject upon intravenous or oral administration of a 13C-labeled CYP2D6 substrate compound. The present invention is useful as an in vivo phenotype assay for evaluating CYP2D6-related activity using the metabolite 13CO2 in expired breath and to determine the optimal dosage and timing of administration of CYP2D6 substrate compound.

    摘要翻译： 本发明一般涉及通过呼吸测定法确定和评估个体哺乳动物受试者中的细胞色素P450 2D6同工酶（CYP2D6）相关代谢能力的方法，通过测定相对量的< 在静脉内或口服给予13 C-标记的CYP2D6底物化合物时，由受试者呼出的SUB> 2 。 本发明可用作体内表型测定法，用于使用呼吸道呼吸中的代谢物13评估CYP2D6相关活性，并确定最佳剂量和施用时间 的CYP2D6底物化合物。

    Disc guiding device for directing discs discharged from a disc passageway
    10.
    发明授权
    Disc guiding device for directing discs discharged from a disc passageway 失效
    用于引导从盘通道排出的盘的盘引导装置

    公开(公告)号：US06821198B2

    公开(公告)日：2004-11-23

    申请号：US10166894

    申请日：2002-06-11

    申请人： Hiroshi Abe ,  Yasuo Irie

    发明人： Hiroshi Abe ,  Yasuo Irie

    IPC分类号： G07D100

    CPC分类号： G07D9/00 ,  G07D1/00

    摘要： A device guiding disc to direct discs to a desired location includes a guiding passageway for guiding and aligning the individual discs at an exit position. A pushing device can contact the discs at the exit position and move the disc out of the guiding passageway. A roller member can be positioned adjacent the bottom of the exit position to support and translate the disc as it is pushed by the pushing device. A support device, such as a tapered roller member, can be positioned above the exit position to receive an upper edge of the disc and to operatively position the disc for subsequent contact with the pushing device wherein the disc is positioned at an inclined angle to a longitudinal axis of the guiding passageway.

    摘要翻译： 装置引导盘将光盘引导到期望的位置包括用于在出口位置引导和对准各个盘的引导通道。 推动装置可以在出口处接触盘，并将盘移出引导通道。 辊子构件可以邻近出口位置的底部定位，以在由推动装置推动时支撑和平移盘。 诸如圆锥滚子构件的支撑装置可以位于出口位置上方以接收盘的上边缘并且可操作地定位盘以便随后与推动装置接触，其中盘以与倾斜角度倾斜的角度定位 引导通道的纵向轴线。