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1.发明申请公开(公告)号：US20230000371A1
公开(公告)日：2023-01-05
申请号：US17941610
申请日：2022-09-09
IPC分类号： A61B5/0215 , A61B5/00
摘要： The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are suited to implantation within the body to monitor physiological conditions, such as portal and/or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the portohepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading.
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公开(公告)号：US20200155014A1
公开(公告)日：2020-05-21
申请号：US16686700
申请日：2019-11-18
发明人： Amir ARTHUR , Nadav SHARON , Amir KOHEN , Amir HAREL , Erez JANAI
IPC分类号： A61B5/0215 , A61B5/00 , A61B8/12 , A61B8/08 , A61B17/34
摘要： Systems and methods for deployment and implantation of an implantable device having an attachment element directly in a luminal wall or tissue to monitor or detect physiological conditions. In an embodiment of the invention, a device is positioned at one or more target locations in the body to enable a medical professional to obtain physiological information for the target site(s). The invention also provides novel methods of monitoring physiological conditions using multiple sensors via techniques such as ultrasound with frequency separation or spatial separation.
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3.发明申请公开(公告)号：US20190320997A1
公开(公告)日：2019-10-24
申请号：US16389202
申请日：2019-04-19
发明人： Amir KOHEN , Yuval BECKER , Eric S. TAMMAM
摘要： A method and system of the invention generally relate to measuring ambient pressure in systems comprising incompressible fluids. Particularly, the method and system relate to monitoring pressure within body lumens. The ambient pressure may be measured by transmitting a frequency comb having non-uniform spacing between transmitted frequencies at the passive sensor and measuring the frequency response of the passive sensor. In one embodiment, a higher-order harmonic of the sensor is excited and measured to determine the ambient pressure. In another embodiment, the frequency response of frequencies in-between the transmitted frequencies are measured to determine the ambient pressure.
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公开(公告)号：US20190175105A1
公开(公告)日：2019-06-13
申请号：US16280418
申请日：2019-02-20
发明人： Yekaterina DLUGACH , Nadav AGIAN
IPC分类号： A61B5/00 , A61F2/915 , A61B5/0215
摘要： This invention relates to an implantable device for a physiologic sensor, comprising an implantable expandable anchor, a bridge on which the sensor is secured, as well as an optional adapting ring. The invention also relates to a method of monitoring bodily functions using the anchor and sensor. The anchor is compressed and the bridge assumes an elongated shape during delivery to a target lumen. Upon deployment at the target site, the anchor expands and the bridge bows into the interior lumen of the expanded anchor, distancing the sensor from the vessel wall. This invention also relates to a method of manufacturing said device and a method of implanting a sensor.
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公开(公告)号：US20190388062A1
公开(公告)日：2019-12-26
申请号：US16445383
申请日：2019-06-19
发明人： Amir KOHEN
摘要： The invention provides an apparatus, system, and method employing a marker based on a membrane that is reflective of ultrasonic waves. The technique allows controlling the resonance frequency of the membrane, amplitude, non-linearity and reverberation period by modifying material properties and geometrical properties (membrane area and thickness) such that the marker appears prominently on ultrasound imaging. The marker can be tailored for use either in color Doppler mode or harmonics mode.
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公开(公告)号：US10238339B2
公开(公告)日：2019-03-26
申请号：US14211397
申请日：2014-03-14
发明人： Yekaterina Dlugach , Nadav Agian
IPC分类号： A61B5/02 , A61B5/00 , A61B5/0215 , A61F2/82 , A61F2/915 , A61B5/145 , A61F2/24 , A61F2/86 , A61B90/00
摘要： This invention relates to an implantable device for a physiologic sensor, comprising an implantable expandable anchor, a bridge on which the sensor is secured, as well as an optional adapting ring. The invention also relates to a method of monitoring bodily functions using the anchor and sensor. The anchor is compressed and the bridge assumes an elongated shape during delivery to a target lumen. Upon deployment at the target site, the anchor expands and the bridge bows into the interior lumen of the expanded anchor, distancing the sensor from the vessel wall. This invention also relates to a method of manufacturing said device and a method of implanting a sensor.
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公开(公告)号：US20160013394A1
公开(公告)日：2016-01-14
申请号：US14796063
申请日：2015-07-10
摘要： The present invention relates to a transducer device having a planar array of electroacoustic cells, each including a piezoelectric bilayer unit. The transducer device achieves high transmission sensitivity across a broad bandwidth. The transducer device may be designed to have a broad or a focused directivity pattern, or may be multi-frequency, depending on the particular application and has a range of applications. For example, the transducer device may be used with an implanted passive ultrasonically excitable resonating sensor, to excite the sensor and/or to interrogate the sensor, for example in conjunction with Doppler-based analysis of the resonance frequency of the sensor, and/or to locate an implanted sensor. The invention also relates to a method of manufacturing the device.
摘要翻译： 本发明涉及具有电声单元的平面阵列的换能器装置，每个包括压电双层单元。 传感器器件在宽带宽下实现高传输灵敏度。 换能器装置可以被设计为具有宽的或聚焦的指向性图案，或者可以是多频的，这取决于具体应用并且具有一系列的应用。 例如，传感器装置可以与植入的被动超声波可激发谐振传感器一起使用，以激励传感器和/或询问传感器，例如结合基于对传感器的共振频率的基于多普勒的分析，和/或 定位植入的传感器。 本发明还涉及一种制造该装置的方法。
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公开(公告)号：US20140275865A1
公开(公告)日：2014-09-18
申请号：US13935001
申请日：2013-07-03
发明人： Eric S. TAMMAM , Oleg WEIZMAN , Yekaterina DLUGACH , Nadav AGIAN
IPC分类号： A61B5/00 , A61B5/145 , B21D31/00 , A61B5/0215
CPC分类号： A61B5/6882 , A61B5/0215 , A61B5/036 , A61B5/145 , A61B5/14503 , A61B5/20 , A61B5/4244 , A61B5/686 , A61B5/6869 , A61B5/6876 , A61B5/6885 , A61B2560/063 , A61B2560/066 , A61B2562/12 , B21D31/00
摘要： The device and method of the invention generally relate to a system and method for percutaneous delivery, implantation and securement of an anchor at a target site. The system comprises an anchor having a bridge, a first stabilizer having a crimped state and a deployed state, a second stabilizer having a crimped state and a deployed state, and a positioning arm. The system may further comprise a cannula, pushrod, and sheath. The system permits the deposit of an anchor at a target location in the body by utilizing a controlled amount of force. The anchors and methods are particularly well-suited to implantation within the body of a living animal or human to monitor various physiological conditions.
摘要翻译： 本发明的装置和方法一般涉及一种用于经皮递送，植入和固定锚点在目标部位的系统和方法。 该系统包括具有桥的锚，具有卷曲状态的第一稳定器和展开状态，具有卷曲状态和展开状态的第二稳定器以及定位臂。 系统还可以包括插管，推杆和护套。 该系统允许通过利用受控量的力将锚固体沉积在身体的目标位置。 锚和方法特别适合于植入活的动物或人的体内以监测各种生理状况。
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公开(公告)号：US20210043825A1
公开(公告)日：2021-02-11
申请号：US17077260
申请日：2020-10-22
摘要： The present invention relates to a transducer device having a planar array of electroacoustic cells, each including a piezoelectric bilayer unit. The transducer device achieves high transmission sensitivity across a broad bandwidth. The transducer device may be designed to have a broad or a focused directivity pattern, or may be multi-frequency, depending on the particular application and has a range of applications. For example, the transducer device may be used with an implanted passive ultrasonically excitable resonating sensor, to excite the sensor and/or to interrogate the sensor, for example in conjunction with Doppler-based analysis of the resonance frequency of the sensor, and/or to locate an implanted sensor. The invention also relates to a method of manufacturing the device.
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10.发明申请公开(公告)号：US20190008400A1
公开(公告)日：2019-01-10
申请号：US16129912
申请日：2018-09-13
IPC分类号： A61B5/0215 , A61B5/00
摘要： The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are particularly well-suited to implantation within the body of a living animal or human to monitor physiological conditions, such as portal and/or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure using the resonance frequency of an implanted sensor. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the porto-hepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading, and is particularly well-suited for detecting portal hypertension in patients with liver disorders.
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