公开(公告)号：US08318781B2

公开(公告)日：2012-11-27

申请号：US12597281

申请日：2008-04-25

申请人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

发明人： Gozoh Tsujimoto ,  Akira Hirasawa ,  Naoki Miyata ,  Takayoshi Suzuki ,  Yoshiyuki Takahara ,  Masaji Ishiguro ,  Mie Hata

IPC分类号： A01N43/40 ,  A01N43/78 ,  A01N37/12 ,  A01N37/44 ,  A01N43/00 ,  A61K31/445 ,  A61K31/425 ,  A61K31/33 ,  C07D213/72 ,  C07D213/78 ,  C07D277/82 ,  C07C63/00 ,  C07C65/00

CPC分类号： C07C311/51 ,  C07C217/18 ,  C07D213/74 ,  C07D215/12 ,  C07D257/04

摘要： Disclosed is a novel aralkyl carboxylic acid compound which has an agonistic activity on GPR-120 and/or GPR-40, particularly GPR-120, and is therefore useful as an appetite regulator, an anti-obesity agent, a therapeutic agent for diabetes, a pancreatic beta differentiating cell growth enhancer, a therapeutic agent for metabolic syndrome, a therapeutic agent for a gastrointestinal disease, a therapeutic agent for a neuropathy, a therapeutic agent for a mental disorder, a therapeutic agent for a pulmonary disease, a therapeutic agent for a pituitary hormone secretion disorder or a lipid flavoring/seasoning agent. The aralkyl carboxylic acid compound is represented by the general formula (I). (I) wherein the ring Q represents a pyridyl or the like; R1 represents a C1-6 alkyl group or the like; R2 represents a hydrogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; m and n independently represent an integer of 1 to 5; and X represents an oxygen atom, a sulfur atom or —NR3— [wherein R3 represents a hydrogen atom or a C1-4 alkyl group].

摘要翻译： 公开了一种对GPR-120和/或GPR-40，特别是GPR-120具有激动作用的新的芳烷基羧酸化合物，因此可用作食欲调节剂，抗肥胖剂，糖尿病治疗剂， 胰腺β分化细胞生长增强剂，代谢综合征治疗剂，胃肠道疾病治疗剂，神经病变治疗剂，精神障碍治疗剂，肺病治疗剂，治疗剂 垂体激素分泌障碍或脂质调味剂/调味剂。 芳烷基羧酸化合物由通式（I）表示。 （I）其中环Q表示吡啶基等; R1表示C1-6烷基等; R2表示氢原子，C1-4烷基或C1-4烷氧基; m和n独立地表示1〜5的整数。 X表示氧原子，硫原子或-NR 3 - [其中R 3表示氢原子或C 1-4烷基]。

公开(公告)号：US20050281918A1

公开(公告)日：2005-12-22

申请号：US10523805

申请日：2003-08-08

申请人： Hiroshi Shibata ,  Mie Hata ,  Hiroaki Sasaki ,  Hiroshi Kono

发明人： Hiroshi Shibata ,  Mie Hata ,  Hiroaki Sasaki ,  Hiroshi Kono

IPC分类号： A23L2/52 ,  A23L1/304 ,  A23L2/00 ,  B01D61/44 ,  C02F1/469 ,  C02F1/68 ,  A23L1/30

CPC分类号： A23L33/16 ,  C02F1/469 ,  C02F2103/08 ,  Y02A20/134

摘要： A seawater mineral component-containing composition is produced which contains mineral components having a good effect on health, such as magnesium and calcium, has a decreased content of sodium, and thus can be used widely for foods. When processed, the seawater mineral component-containing composition provides foods and beverages useful for preventing cardiovascular diseases and lifestyle-related diseases. The seawater mineral component-containing composition is obtained by subjecting seawater to electrodialysis, and has a sodium concentration of 6 mg/L or less when adjusted to form an aqueous solution having a hardness of 100 (EDTA method).

摘要翻译： 制备含有对健康有良好效果的矿物质组分如镁和钙的具有降低的钠含量的海水含矿物组分的组合物，因此可广泛用于食品。 当加工时，含海水矿物成分的组合物提供用于预防心血管疾病和与生活方式有关的疾病的食物和饮料。 含海水矿物成分组合物是通过对海水进行电渗析而得到的，调整浓度为6mg / L以下，形成硬度为100（EDTA法）的水溶液时。