公开(公告)号：US20120142103A1

公开(公告)日：2012-06-07

申请号：US13321130

申请日：2010-05-18

申请人： Kohji Nishida ,  Ryuhei Hayashi ,  Miharu Sakurai ,  Tomofumi Kageyama ,  Shinya Yamanaka ,  Keisuke Okita

发明人： Kohji Nishida ,  Ryuhei Hayashi ,  Miharu Sakurai ,  Tomofumi Kageyama ,  Shinya Yamanaka ,  Keisuke Okita

IPC分类号： C12N5/071

CPC分类号： A61L27/3834 ,  A61L27/3869 ,  A61L27/3895 ,  C12N5/0621 ,  C12N5/0629 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/39 ,  C12N2501/395 ,  C12N2502/1323 ,  C12N2502/1394 ,  C12N2506/45

摘要： The present invention relates to: a method for inducing differentiation into an epithelial progenitor cell/stem cell population or a corneal epithelial cell population by culturing, under particular conditions, induced pluripotent stem cells induced from mammalian somatic cells or undifferentiated stem cells; an epithelial progenitor cell/stem cell population or a corneal epithelial cell population obtained by the method; and a cell preparation for the treatment of epithelial disease and a cell sheet, which are prepared using these cell populations.

摘要翻译： 本发明涉及：通过在特定条件下培养从哺乳动物体细胞或未分化干细胞诱导的多能干细胞诱导分化成上皮祖细胞/干细胞群或角膜上皮细胞群的方法; 通过该方法获得的上皮祖细胞/干细胞群或角膜上皮细胞群; 以及用这些细胞群制备的用于治疗上皮疾病和细胞片的细胞制剂。