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    CLINICIAN-CONTROLLED SEMI-AUTOMATED MEDICATION MANAGEMENT
    2.
    发明申请
    CLINICIAN-CONTROLLED SEMI-AUTOMATED MEDICATION MANAGEMENT 审中-公开
    临床控制的半自动药物管理

    公开(公告)号：US20090054754A1

    公开(公告)日：2009-02-26

    申请号：US12188205

    申请日：2008-08-08

    申请人： Dave McMahon ,  Mark Ries Robinson ,  Mike Borrello ,  Richard Thompson ,  Shonn Hendee

    发明人： Dave McMahon ,  Mark Ries Robinson ,  Mike Borrello ,  Richard Thompson ,  Shonn Hendee

    IPC分类号： A61B5/145 ,  A61M5/00

    CPC分类号： A61M5/1723 ,  A61M2005/14296 ,  A61M2230/201 ,  G06F19/3468

    摘要： The present invention is directed to methods and apparatuses of medication management based upon active authorization of medication infusion by a clinician that can provide for effective management of an analyte in a patient's blood, reducing the opportunities for human error common with current manual systems while still placing final control of the medication management with the human clinician. For example, a semi-automated glucose management system can measure the glucose level in a patient's blood, recommend infusion parameters to a clinician who can authorize an infusion of glucose or insulin, and infuse the glucose or insulin into the patient.

    摘要翻译： 本发明涉及药物治疗方法和装置，其基于临床医生的药物输注的主动授权，其可以提供对患者血液中的分析物的有效管理，减少与当前手动系统共同的人为错误的机会，同时仍然放置 最终控制用药管理与人体临床医师。 例如，半自动葡萄糖管理系统可以测量患者血液中的葡萄糖水平，向可以授权输注葡萄糖或胰岛素的临床医生推荐输注参数，并将葡萄糖或胰岛素注入患者体内。

    Variable Sampling Interval for Blood Analyte Determinations
    3.
    发明申请
    Variable Sampling Interval for Blood Analyte Determinations 审中-公开
    血液分析物测定的可变取样间隔

    公开(公告)号：US20090054753A1

    公开(公告)日：2009-02-26

    申请号：US11842624

    申请日：2007-08-21

    申请人： Mark Ries Robinson ,  Mike Borrello ,  Dave McMahon

    发明人： Mark Ries Robinson ,  Mike Borrello ,  Dave McMahon

    IPC分类号： A61B5/00 ,  G01N33/50

    CPC分类号： A61B5/14503 ,  A61B5/14532 ,  G06F19/3456 ,  G16H40/63 ,  G16H50/20 ,  G16H50/50

    摘要： The present invention provides methods and apparatuses that can provide measurement of glucose with variable intervals between measurements, allowing more efficient measurement with greater patient safety. A method according to the present invention can comprise measuring the value of an analyte such as glucose at a first time; determining a second time from a patient condition, an environmental condition, or a combination thereof; then measuring the value of the analyte at the second time (where the second time can be expressed as an interval after the first time, an absolute time, or a time indicated when certain patient or environmental conditions, or both, are reached or detected). The second time can be determined, as an example, from a comparison of the analyte value at the first time with a threshold. The interval between the first time and the second time can be related to the difference between the analyte value at the first time and the threshold; e.g., the closer to the threshold, the closer the two measurement times. The invention can be used with automated measurement systems, allowing the system to determine measurement times and automatically make measurements at the determined times, reducing operator interaction and operator error.

    摘要翻译： 本发明提供了可以在测量之间提供可变间隔的葡萄糖测量的方法和装置，从而允许更有效的测量，从而提高患者的安全性。 根据本发明的方法可以包括在第一时间测量诸如葡萄糖的分析物的值; 从患者状况，环境状况或其组合确定第二次; 然后在第二时间测量分析物的值（其中第二次可以表示为第一次之后的间隔，绝对时间，或在达到或检测到某些患者或环境条件或两者时指示的时间） 。 作为示例，可以从第一次的分析物值与阈值的比较确定第二次。 第一时间和第二时间之间的间隔可以与第一时间的分析物值和阈值之间的差异相关; 例如越接近阈值，两个测量时间越接近。 本发明可以与自动测量系统一起使用，允许系统确定测量时间，并在确定的时间自动进行测量，减少操作人员的交互和操作者的错误。

    Managing Cross-contamination in Blood Samples Withdrawn from a Multilumen Catheter
    4.
    发明申请
    Managing Cross-contamination in Blood Samples Withdrawn from a Multilumen Catheter 审中-公开
    管理从多次导管撤回的血液样本中的交叉污染

    公开(公告)号：US20090048576A1

    公开(公告)日：2009-02-19

    申请号：US11860544

    申请日：2007-09-25

    申请人： Mark Ries Robinson ,  Mike Borrello ,  John O'Mahony ,  Richard Thompson ,  Dave Tobler ,  V. Gerald Grafe

    发明人： Mark Ries Robinson ,  Mike Borrello ,  John O'Mahony ,  Richard Thompson ,  Dave Tobler ,  V. Gerald Grafe

    IPC分类号： A61M25/01

    CPC分类号： A61B5/150961 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/155 ,  A61B5/157

    摘要： The present invention comprises methods and apparatuses that can provide accurate measurement of glucose or other analytes from a multilumen catheter in the presence of infusion of substances, including glucose. Examples of “multilumen catheters” include central venous catheters having multiple lumens, midline catheters having multiple lumens, multiple catheters configured or emplaced such that their lumens are in proximity to each other, and, in the case of indwelling analyte sensors, a catheter with a lumen for infusion and an indwelling sensor spaced apart from the infusion lumen. For blood withdrawal, anti-cross contamination controls can prevent the entrainment of blood which might be contaminated with feeding fluids or medications that are administered through other lumens within the catheter and in proximity of the blood sampling port. Cross contamination can occur under various situations, and is known to occur when the patient is connected to a ventilator. The ventilator cyclically raises the intra-thoracic pressure and diminishes blood flow rate in the central veins returning to the heart. The diminished flow can increase the chances for cross-contamination when additional lumens are introducing fluids during a draw sample.

    摘要翻译： 本发明包括在存在输入物质（包括葡萄糖）的情况下可以提供来自多腔导管的葡萄糖或其它分析物的精确测量的方法和装置。 “多腔导管”的实例包括具有多个腔的中心静脉导管，具有多个腔的中线导管，配置或放置多个导管，使得它们的内腔彼此靠近，并且在留置分析物传感器的情况下， 用于输注的内腔和与输液腔间隔开的留置传感器。 为了取血，反交叉污染控制可以防止可能被导管内和在血液采样端口附近通过其他管腔给药液体或药物而被污染的血液夹带。 交叉污染可以在各种情况下发生，并且已知当患者连接到通气机时发生交叉污染。 呼吸机周期性地升高胸腔内压，并减少返回心脏的中央静脉血流量。 减少的流量可以增加在抽取样品期间附加管腔引入流体时交叉污染的机会。

    HEMODYNAMIC MONITORING DURING AUTOMATED MEASUREMENT OF BLOOD CONSTITUENTS
    7.
    发明申请
    HEMODYNAMIC MONITORING DURING AUTOMATED MEASUREMENT OF BLOOD CONSTITUENTS 审中-公开
    血液自动测量期间的血液动力学监测

    公开(公告)号：US20100094113A1

    公开(公告)日：2010-04-15

    申请号：US12576121

    申请日：2009-10-08

    申请人： Mark Ries Robinson ,  Mike Borrello ,  William R. Patterson

    发明人： Mark Ries Robinson ,  Mike Borrello ,  William R. Patterson

    IPC分类号： A61B5/1473 ,  A61B5/02 ,  A61B5/021

    CPC分类号： A61B5/0215 ,  A61B5/14532 ,  A61B5/14546

    摘要： The present invention provides methods and apparatuses that can provide measurement of analytes such as glucose with a variety of sensors in connection with hemodynamic monitoring. Some embodiments of the present invention enable the use of a single arterial access site for automated blood glucose measurement as well as hemodynamic monitoring. Some embodiments of the present invention can reduce or eliminate nuisance hemodynamic alarms. Some embodiments of the present invention can provide hemodynamic monitoring during an automated analyte measurement process. An example apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with or integrated into the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system.

    摘要翻译： 本发明提供了可以提供诸如葡萄糖等分析物与血液动力学监测相结合的各种传感器的测量方法和装置。 本发明的一些实施例使得能够使用单个动脉进入部位进行自动血糖测量以及血液动力学监测。 本发明的一些实施例可以减少或消除麻烦的血液动力学警报。 本发明的一些实施方案可以在自动分析物测量过程中提供血液动力学监测。 根据本发明的示例性装置包括血液存取系统，其适于从身体去除血液并将至少一部分血液注入体内。 这样的装置还包括安装有或集成到血液存取系统中的分析物传感器，使得分析物传感器测量血液中已被血液存取系统从体内除去的分析物。

    Robust System and Methods for Blood Access
    9.
    发明申请
    Robust System and Methods for Blood Access 审中-公开
    健壮的血液系统和方法

    公开(公告)号：US20090156975A1

    公开(公告)日：2009-06-18

    申请号：US12325243

    申请日：2008-11-30

    申请人： Mark Ries Robinson ,  Mike Borrello ,  Dan Welsh

    发明人： Mark Ries Robinson ,  Mike Borrello ,  Dan Welsh

    IPC分类号： A61M1/14 ,  B01D65/02

    CPC分类号： A61M1/3653 ,  A61B5/0215 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150946 ,  A61B5/150961 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2005/1588 ,  A61M2039/0009

    摘要： Embodiments of the present invention provide robust systems for the removal and subsequent infusion of blood for measurement purposes, and embodiments of the present invention provide methods of operating such systems and providing capabilities such as predicting and avoiding occlusions and/or bubbles, managing occlusions and/or bubbles if they occur, automatic cleaning of the blood access system, and determining and managing the patency of the blood access site. Such operational challenges can occur during any of several phases of operation of a blood access system. Embodiments of the present invention can effectively incorporate a variety of inputs for the identification of trends consistent with present or pending occlusions. An embodiment of the present invention can be aware of the stage of operation, e.g., withdrawal, infusion, or cleaning, and the prior performance of the system. Embodiments of the present invention can have the ability to identify the location of the problem so that effective procedures can be used to resolve the problem.

    摘要翻译： 本发明的实施例提供用于去除和随后输注用于测量目的的血液的鲁棒系统，并且本发明的实施例提供了操作这样的系统并提供诸如预测和避免闭塞和/或气泡的能力的方法，管理闭塞和/ 如果发生气泡，自动清洗血液存取系统，以及确定和管理血液通道的通畅。 这样的操作挑战可以在血液存取系统的几个操作阶段的任何阶段发生。 本发明的实施例可以有效地结合用于识别与当前或未决遮挡一致的趋势的各种输入。 本发明的实施例可以意识到操作的阶段，例如撤回，输注或清洁，以及系统的先前的执行。 本发明的实施例可以具有识别问题的位置的能力，从而可以使用有效的过程来解决问题。

    Detecting Cross-contamination in Blood Measurements with a Multilumen Catheter
    10.
    发明申请
    Detecting Cross-contamination in Blood Measurements with a Multilumen Catheter 审中-公开
    用多次导管检测血液测量中的交叉污染

    公开(公告)号：US20090048535A1

    公开(公告)日：2009-02-19

    申请号：US11860545

    申请日：2007-09-25

    申请人： Mark Ries Robinson ,  Mike Borrello ,  John O'Mahony ,  Richard Thompson ,  V. Gerald Grafe

    发明人： Mark Ries Robinson ,  Mike Borrello ,  John O'Mahony ,  Richard Thompson ,  V. Gerald Grafe

    IPC分类号： A61B5/155

    CPC分类号： A61B5/150961 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/155 ,  A61B5/157

    摘要： The present invention comprises methods and apparatuses that can provide accurate measurement of glucose or other analytes from a multilumen catheter in the presence of infusion of substances, including glucose. Examples of “multilumen catheters” include central venous catheters having multiple lumens, midline catheters having multiple lumens, multiple catheters configured or emplaced such that their lumens are in proximity to each other, and, in the case of indwelling analyte sensors, a catheter with a lumen for infusion and an indwelling sensor spaced apart from the infusion lumen. For blood withdrawal, anti-cross contamination controls can prevent the entrainment of blood which might be contaminated with feeding fluids or medications that are administered through other lumens within the catheter and in proximity of the blood sampling port. Cross contamination can occur under various situations, and is known to occur when the patient is connected to a ventilator. The ventilator cyclically raises the intra-thoracic pressure and diminishes blood flow rate in the central veins returning to the heart. The diminished flow can increase the chances for cross-contamination when additional lumens are introducing fluids during a draw sample.

    摘要翻译： 本发明包括在存在输入物质（包括葡萄糖）的情况下可以提供来自多腔导管的葡萄糖或其它分析物的精确测量的方法和装置。 “多腔导管”的实例包括具有多个内腔的中心静脉导管，具有多个腔的中线导管，多个导管被配置或放置成使得它们的内腔彼此靠近，并且在留置分析物传感器的情况下， 用于输注的内腔和与输液腔间隔开的留置传感器。 为了取血，反交叉污染控制可以防止可能被导管内和在血液采样端口附近通过其他管腔给药液体或药物而被污染的血液夹带。 交叉污染可以在各种情况下发生，并且已知当患者连接到通气机时发生交叉污染。 呼吸机周期性地升高胸腔内压，并减少返回心脏的中央静脉血流量。 减少的流量可以增加在抽取样品期间附加管腔引入流体时交叉污染的机会。