公开(公告)号：US5876949A

公开(公告)日：1999-03-02

申请号：US455073

申请日：1995-05-31

申请人： Gideon Dreyfuss ,  Mikiko C. Siomi ,  Yan Zhang

发明人： Gideon Dreyfuss ,  Mikiko C. Siomi ,  Yan Zhang

IPC分类号： C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/567 ,  C07K16/28 ,  C12P21/08

CPC分类号： C07K14/47 ,  C07K16/18 ,  C12Q1/6876 ,  C12Q2600/158

摘要： The present invention relates to substantially pure FXR1 and FXR2 proteins and isolated nucleic acid molecules encoding the same. Recombinant expression vectors comprising nucleic acid sequences that encode FXR1 and FXR2 protein are also provided. Antibodies which bind to an epitope of FXR1 or FXR2, or FMR1 protein are also provided. The present invention also relates to methods of screening individuals for FMR1 deficiency using antibodies or nucleic acid molecules of the invention and pharmaceutical kits for accomplishing the same.

摘要翻译： 本发明涉及基本上纯的FXR1和FXR2蛋白以及编码其的分离的核酸分子。 还提供了包含编码FXR1和FXR2蛋白的核酸序列的重组表达载体。 还提供了结合FXR1或FXR2或FMR1蛋白表位的抗体。 本发明还涉及使用本发明的抗体或核酸分子筛选个体用于FMR1缺陷的方法和用于实现本发明的药物试剂盒的方法。