摘要:
A hybridization carrier, containing a single-stranded polynucleotide having the formula:5'-(dN).sub.n (dT).sub.m -3',wherein N represents admine, guanine or cytosin; T represents thymine; n is an integer of 2 or larger; and m is an integer of 5 or larger;the polynucleotide being immobilized by an amide bond on a surface of an organic polymers particle having a diameter of from about 0.05 .mu.m to about 5 .mu.m;the polynucleotide being immobilized at the site of a nucleotide sequence consisting of 2 or more polynucleotide which contain a primary amino residue in the polynucleotide; andthe amide bond having been formed between the primary amino residue and a carboxyl residue on the surface of the organic polymer particle.
摘要:
A process of producing particles for diagnostic reagent, including forming a matrix particle by mixing a nuclear particle having a CV value of 20% or less and a magnetic substance containing at least one of Fe2O3 and Fe3O4 and giving a shear force to the mixture to adsorb the magnetic substance on the surface of the nuclear particles; and polymerizing a polymerizable monomer in the presence of said matrix particle to form a polymer layer on the magnetic substance layer.
摘要翻译:制造用于诊断试剂的颗粒的方法,包括通过混合CV值为20%以下的核粒子和含有Fe 2 O 3和Fe 3 O 4中的至少一种的磁性物质形成基质颗粒,并向该混合物吸附而产生剪切力 核粒子表面的磁性物质; 并在所述基体颗粒的存在下聚合可聚合单体以在磁性物质层上形成聚合物层。
摘要:
A particle for a diagnostic agent, which comprises a polymer particle comprising (A) from 20 to 100% by weight of a structural unit derived from at least one of acrylate having an aliphatic hydrocarbon group and methacrylate having an aliphatic hydrocarbon group, (B) from 0 to 10% by weight of a structural unit derived from unsaturated carboxylic acid, and (C) from 0 to 80% by weight of a structural unit derived from a vinyl monomer copolymerizable with the acrylate, methacrylate and unsaturated carboxylic acid, and a turbidmetric immunoassay using the same.
摘要:
A process of producing particles for diagnostic reagent, including forming a matrix particle by mixing a nuclear particle having a CV value of 20% or less and a magnetic substance containing at least one of Fe2O3 and Fe3O4 and giving a shear force to the mixture to adsorb the magnetic substance on the surface of the nuclear particles; and polymerizing a polymerizable monomer in the presence of said matrix particle to form a polymer layer on the magnetic substance layer.
摘要翻译:一种生产用于诊断试剂的颗粒的方法,包括通过混合CV值为20%以下的核粒子和含有至少一种Fe 2 O 3的磁性体形成基质颗粒, 3和Fe 3 O 4,并向混合物施加剪切力以将磁性物质吸附在核粒子的表面上; 并在所述基体颗粒的存在下聚合可聚合单体以在磁性物质层上形成聚合物层。
摘要:
A process of producing particles for diagnostic reagent, including a step of polymerizing a polymerizable monomer in the presence of a matrix particle having a magnetic substance layer containing at least one of Fe2O3 and Fe3O4 on the surface thereof and having a mean particle size of 0.4-200 &mgr;m to form a polymer layer on the magnetic substance layer.
摘要翻译:一种生产用于诊断试剂的颗粒的方法,包括在其表面上具有含有至少一种Fe 2 O 3和Fe 3 O 4的磁性物质层的基质颗粒的存在下聚合可聚合单体并具有0.4〜 200微米,以在磁性物质层上形成聚合物层。