摘要:
Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovirus infections like AIDS and AIDS-related diseases. Their antiviral activity is apparently based on inhibition of virus adsorption; their inhibitory effect on giant cell formation is stronger than that of dextran sulphate.
摘要:
The invention relates to new, pharmaceutically active copolymers with heparin-like activity, pharmaceutically acceptable salts thereof and a process for their preparation. The new copolymers comprise the units of the formula I ##STR1## wherein X stands for hydrogen or methyl and Y is hydrogen, units of the formula III ##STR2## optionally units of the formula II ##STR3## wherein Z' is hydrogen, and chain terminating units, formed from the units of the formulae I, III and optionally II under the conditions of copolymerization, in a statistical arrangement, and the pharmaceutically acceptable salts thereof, which contain, in addition to the above chain-members, units of the formulae IV and/or V ##STR4## wherein A is a cation/ satisfactorily replace the organogenic heparin, or give a synergistic combination with that,
摘要翻译:本发明涉及具有肝素样活性的新的药物活性共聚物及其药学上可接受的盐及其制备方法。 新的共聚物包含式I的单元/ I /其中X代表氢或甲基,Y是氢,式III的单元/ III /任选的式II单元/ IMAGE /其中Z'为氢,以及由式I,III和任选II的单元在统计学排列的共聚条件下形成的链终止单元及其药学上可接受的盐,除了 上述链成员,式IV和/或V的单元/ IV / / V /其中A
摘要:
Sulphated vinyl polymers such as sulphated polyvinylalcohol, sulphated copolymers of (meth)acrylic acid and vinylalcohol, and pharmaceutically acceptable salts thereof, have an antiviral effect against human immunodeficiency virus and may therefore be used as a therapeutic agent for treating retrovirus infections like AIDS and AIDS-related diseases. Their antiviral activity is apparently based on inhibition of virus adsorption; their inhibitory effect on giant cell formation is stronger than that of dextran sulphate.
摘要:
This invention relates to novel partially saponified polyvinyl acetates with a degree of hydrolysis of 30 to 65 mole % which might be considered as vinyl alcohol-vinyl acetate block copolymers. The invention relates further to the application of said novel block copolymers as a pore-forming additive used together with at least one known protective colloid in the homo- and copolymerization of vinyl compounds, primarily of vinyl chloride in a pure aqueous medium.