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公开(公告)号：US20110020385A1
公开(公告)日：2011-01-27
申请号：US12791186
申请日：2010-06-01
CPC分类号： A61K39/092
摘要： Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
摘要翻译： 肺炎球菌菌丝亚单位RrgB至少有三个进化枝。 对特定进化枝提出的血清是针对表达RrgB进化枝的肺炎球菌活跃的，但不反对表达其他两个进化枝之一的菌株，即具有进化枝交叉保护，而不是进化枝交叉保护。 因此，免疫原性组合物可以包括至少两个不同的RrgB进化枝，以改善针对含有菌毛的肺炎球菌的菌株覆盖。 这些多个进化枝可以作为单独的多肽存在于免疫原性组合物中，或者可以作为单个多肽链融合。
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公开(公告)号：US08609106B2
公开(公告)日：2013-12-17
申请号：US12791186
申请日：2010-06-01
CPC分类号： A61K39/092
摘要： Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
摘要翻译： 肺炎球菌菌丝亚单位RrgB至少有三个进化枝。 对特定进化枝提出的血清是针对表达RrgB进化枝的肺炎球菌活跃的，但不反对表达其他两个进化枝之一的菌株，即具有进化枝交叉保护，而不是进化枝交叉保护。 因此，免疫原性组合物可以包括至少两个不同的RrgB进化枝，以改善针对含有菌毛的肺炎球菌的菌株覆盖。 这些多个进化枝可以作为单独的多肽存在于免疫原性组合物中，或者可以作为单个多肽链融合。
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公开(公告)号：US20120076814A1
公开(公告)日：2012-03-29
申请号：US13375759
申请日：2010-06-01
CPC分类号： A61K39/092
摘要： Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
摘要翻译： 肺炎球菌菌丝亚单位RrgB至少有三个进化枝。 对特定进化枝提出的血清是针对表达RrgB进化枝的肺炎球菌活跃的，但不反对表达其他两个进化枝之一的菌株，即具有进化枝交叉保护，而不是进化枝交叉保护。 因此，免疫原性组合物可以包括至少两个不同的RrgB进化枝，以改善针对含有菌毛的肺炎球菌的菌株覆盖。 这些多个进化枝可以作为单独的多肽存在于免疫原性组合物中，或者可以作为单个多肽链融合。
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公开(公告)号：US20110097360A1
公开(公告)日：2011-04-28
申请号：US12451736
申请日：2008-05-23
IPC分类号： A61K39/09 , C07K2/00 , C12N9/00 , C07K14/315 , C07K4/04 , C07H21/00 , C07H21/04 , C12N1/20 , A61P37/04 , A61P31/04
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , A61K2039/53 , C12N9/52 , G01N33/56944 , G01N2333/315 , G01N2469/10
摘要： Polypeptides from Streptococcus pneumoniae are described. In some aspects the polypeptides include pili polypeptides from a second pili island (pilus II island (INV1 04B)) identified in Streptococcus pneumoniae isolate INV1 04. In other aspects the polypeptides include pili polypeptides and non-pilus polypeptides from Streptococcus pneumoniae strains 23F, INV200, and OXC141 that are absent from Streptococcus pneumoniae isolate INV104. The polypeptides, including fragments and variants thereof, may be used in immunogenic compositions for prophylactic or therapeutic immunization against Streptococcus pneumoniae. The polypeptides are also disclosed to be used in compositions useful for the production of antibodies and immunostimulants. Also presented are methods of inhibiting Streptococcus pneumoniae, methods of treating Streptococcus pneumoniae infection, methods of identifying inhibitors of Streptococcus pneumoniae and methods for diagnosing/detecting Streptococcus pneumoniae infection.
摘要翻译： 描述了来自肺炎链球菌的多肽。 在一些方面，多肽包括来自肺炎链球菌分离株INV104中鉴定的第二个皮岛（pilus II岛（INV1 04B））的多肽。在其它方面，多肽包括来自肺炎链球菌菌株23F，INV200的多肽和非菌毛多肽 和OXC141，其不存在于肺炎链球菌分离株INV104中。 多肽，包括其片段和变体，可用于免疫原性组合物用于针对肺炎链球菌的预防性或治疗性免疫。 还公开了将多肽用于可用于生产抗体和免疫增强剂的组合物中。 还提出了抑制肺炎链球菌的方法，肺炎链球菌感染的治疗方法，肺炎链球菌抑制剂的鉴定方法和肺炎链球菌感染的诊断方法。
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