-
公开(公告)号：US08609106B2
公开(公告)日：2013-12-17
申请号：US12791186
申请日：2010-06-01
CPC分类号： A61K39/092
摘要： Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
摘要翻译： 肺炎球菌菌丝亚单位RrgB至少有三个进化枝。 对特定进化枝提出的血清是针对表达RrgB进化枝的肺炎球菌活跃的，但不反对表达其他两个进化枝之一的菌株，即具有进化枝交叉保护，而不是进化枝交叉保护。 因此，免疫原性组合物可以包括至少两个不同的RrgB进化枝，以改善针对含有菌毛的肺炎球菌的菌株覆盖。 这些多个进化枝可以作为单独的多肽存在于免疫原性组合物中，或者可以作为单个多肽链融合。
-
公开(公告)号：US20120076814A1
公开(公告)日：2012-03-29
申请号：US13375759
申请日：2010-06-01
CPC分类号： A61K39/092
摘要： Pneumococcal pilus subunit RrgB has at least three clades. Serum raised against a given clade is active against pneumococci which express that RrgB clade, but is not active against strains which express one of the other two clades i.e. there is intra-clade cross-protection, but not inter-clade cross-protection. Thus an immunogenic composition can include at least two different clades of RrgB to improve strain coverage against pilus-containing pneumococci. These multiple clades may be present in the immunogenic composition as separate polypeptides or may be fused as a single polypeptide chain.
摘要翻译： 肺炎球菌菌丝亚单位RrgB至少有三个进化枝。 对特定进化枝提出的血清是针对表达RrgB进化枝的肺炎球菌活跃的，但不反对表达其他两个进化枝之一的菌株，即具有进化枝交叉保护，而不是进化枝交叉保护。 因此，免疫原性组合物可以包括至少两个不同的RrgB进化枝，以改善针对含有菌毛的肺炎球菌的菌株覆盖。 这些多个进化枝可以作为单独的多肽存在于免疫原性组合物中，或者可以作为单个多肽链融合。
-
公开(公告)号：US20110243976A1
公开(公告)日：2011-10-06
申请号：US12733010
申请日：2008-08-01
申请人： Claudia Donati , Alessadro Muzzi , Vega Masignani , Fabio Bagnoli , Paolo Ruggiero , Michèle Anne Barocchi
发明人： Claudia Donati , Alessadro Muzzi , Vega Masignani , Fabio Bagnoli , Paolo Ruggiero , Michèle Anne Barocchi
IPC分类号： A61K39/09 , A61K39/116 , A61K39/295 , A61K39/385 , C07K14/315 , C12N15/31 , C12N1/21 , A61P37/04
CPC分类号： A61K39/092 , C07K14/3156 , C07K2319/40 , Y02A50/466
摘要： Disclosed herein are various combinations of pneumococcal polypeptides for use in immunisation. Also disclosed herein are pneumococcal polypeptides that may be useful as single antigens. These polypeptides may optionally be used in combination with pneumococcal saccharides. The antigens may be used in pneumococcal vaccines, but may also be used as components in vaccines for immunising against multiple pathogens.
摘要翻译： 本文公开了用于免疫的肺炎球菌多肽的各种组合。 本文还公开了可用作单一抗原的肺炎球菌多肽。 这些多肽可以任选地与肺炎球菌糖组合使用。 抗原可以用于肺炎球菌疫苗，但也可以作为免疫多种病原体的疫苗中的组分使用。
-
公开(公告)号：US5922573A
公开(公告)日：1999-07-13
申请号：US809185
申请日：1997-04-15
申请人： Diana Boraschi , Paola Bossu , Paolo Ruggiero , Giovanni Macchia , Aldo Tagliabue , Francesco Frigerio , Renata Grifantini , Gianni Frascotti , Guido Grandi
发明人： Diana Boraschi , Paola Bossu , Paolo Ruggiero , Giovanni Macchia , Aldo Tagliabue , Francesco Frigerio , Renata Grifantini , Gianni Frascotti , Guido Grandi
CPC分类号： C07K14/54 , A61K38/00 , Y10S930/141
摘要： DNA molecules that code for IL-1 antagonists with improved biological activity arc described. DNA molecules coding for improved IL-1 antagonists inserted into expression vectors and host cells transformed with the said vectors containing the DNA coding for improved IL-1 antagonists and a method for the production of improved IL-1 antagonists in essentially pure form are also described. Preparations that can be injected or can be administered by some other route, consisting of a pharmaceutical preparation of the said mutants, are particularly useful as drugs in the field of therapy.
摘要翻译： PCT No.PCT / EP95 / 03708 Sec。 371日期1997年04月15日 102（e）1997年4月15日PCT PCT 1995年9月20日PCT公布。 公开号WO96 / 09323 描述1996年3月28日描述了编码具有改善的生物活性的IL-1拮抗剂的DNA分子。 还描述了编码插入到表达载体中的改良的IL-1拮抗剂和用含有编码改进的IL-1拮抗剂的DNA的所述载体转化的宿主细胞的DNA分子和用于生产基本上纯的形式的改良的IL-1拮抗剂的方法 。 可以通过由所述突变体的药物制剂组成的其它途径注射或可以给药的制剂在治疗领域中特别有用。
-
公开(公告)号：US20050064537A1
公开(公告)日：2005-03-24
申请号：US10221854
申请日：2001-03-15
IPC分类号： G01N33/50 , C12Q1/28 , G01N27/447 , G01N33/535 , G01N33/58 , G01N33/68 , C12N9/08 , C12P21/06
CPC分类号： C12Q1/28 , G01N33/581 , G01N33/6803
摘要： A method for the preparation of molecular weight standards having peroxidase activity which can be directly identified at the time of the detection of the antigen in all western blot techniques based on the use of peroxidase.
摘要翻译： 一种制备具有过氧化物酶活性的分子量标准品的方法，该方法可以基于使用过氧化物酶的所有蛋白质印迹技术在检测抗原时直接鉴定。
-
公开(公告)号：US08479591B2
公开(公告)日：2013-07-09
申请号：US12643881
申请日：2009-12-21
CPC分类号： B64F5/60
摘要： Gripping claws and pairs of arched angular profiles are arranged along the perimeter of a cylindrical surface segment so as to grip the edges of a fuselage panel, closing the opening of a pressurizable chamber.
摘要翻译： 沿着圆柱形表面段的周边布置有夹爪和成对的拱形角形轮廓，以便夹紧机身面板的边缘，从而关闭可加压室的开口。
-
公开(公告)号：US20100186519A1
公开(公告)日：2010-07-29
申请号：US12643881
申请日：2009-12-21
IPC分类号： G01M5/00
CPC分类号： B64F5/60
摘要： Gripping claws and pairs of arched angular profiles are arranged along the perimeter of a cylindrical surface segment so as to grip the edges of a fuselage panel, closing the opening of a pressurizable chamber.
摘要翻译： 沿着圆柱形表面段的周边布置有夹爪和成对的拱形角形轮廓，以便夹紧机身面板的边缘，从而关闭可加压室的开口。
-
8.发明申请COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEIN AND PNEUMOCOCCAL SACCHARIDE CONJUGATES 审中-公开肉毒杆菌因子H结合蛋白和肺癌细胞结合蛋白的组合公开(公告)号：US20120064103A1
公开(公告)日：2012-03-15
申请号：US13260548
申请日：2010-03-24
IPC分类号： A61K39/095 , A61P37/04
CPC分类号： A61K39/095 , A61K39/092 , A61K2039/55505 , A61K2039/6037 , A61K2039/70
摘要： An immunogenic composition comprising: (i) a conjugated pneumococcal capsular saccharide; and (ii) a meningococcal factor H binding protein (fHBP) antigen, and not including meningococcal outer membrane vesicles, is useful for immunising a subject against bacterial meningitis.
摘要翻译： 一种免疫原性组合物，其包含：（i）共轭肺炎球菌荚膜糖; 和（ii）脑膜炎球菌因子H结合蛋白（fHBP）抗原，不包括脑膜炎球菌外膜囊泡，可用于免疫受试者免受细菌性脑膜炎。
-
9.发明授权
公开(公告)号：US4954433A
公开(公告)日：1990-09-04
申请号：US239642
申请日：1988-09-02
申请人： Paolo Ruggiero , Roberto Petracca
发明人： Paolo Ruggiero , Roberto Petracca
CPC分类号： G01N33/581 , G01N2001/2846 , Y10S435/81 , Y10S435/96 , Y10S436/825 , Y10S436/827
摘要： A method is disclosed for the immunolocalization of epitopes of non-glucidic nature, in cellular cultures, in tissue slices, or immobilized on such supports as nitrocellulose, by means of the incubation of the sample with specific antibodies for the antigen to be immunolocalized, belonging to the class of the IgM's, and sequential treatment of concanavalin A and with an enzymatic marker capable of binding with concanavalin A, such as, e.g., peroxidase. The method comprises, before the incubation, a suitable treatment of the sample under test, e.g., with periodic acid, in order to prevent concanavalin A from binding with the carbohydrates present in the sample.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.044 秒)
