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公开(公告)号：US07687454B2
公开(公告)日：2010-03-30
申请号：US10661471
申请日：2003-09-12
申请人： Robert E. W. Hancock , B. Brett Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Melissa Rosenberger , Jon-Paul Steven Powers
发明人： Robert E. W. Hancock , B. Brett Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Melissa Rosenberger , Jon-Paul Steven Powers
CPC分类号： C12Q1/6883 , A61K38/10 , A61K38/1709 , A61K38/193 , C07K7/08 , C07K14/4723 , C07K14/521 , C07K14/7158 , C12Q2600/158 , G01N33/5047 , G01N33/505 , A61K2300/00
摘要： A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
摘要翻译： 描述了鉴定由一种或多种脓毒症或炎性诱导剂调节并被肽抑制的多核苷酸的多核苷酸或图案的方法。 鉴定抑制炎性或败血症反应的多核苷酸表达模式的方法。 该方法包括在存在或不存在阳离子肽的情况下使细胞与LPS，LTA，CpG DNA和/或完整的微生物或微生物组分接触; 在存在和不存在肽的情况下检测细胞的多核苷酸表达的模式，其中在肽存在下的图案表示炎症或败血病应答的抑制。 还包括通过本发明的方法鉴定的化合物和试剂。 另一方面，本发明提供用于增强受试者的先天免疫力的方法和化合物。
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公开(公告)号：US20070190533A1
公开(公告)日：2007-08-16
申请号：US11241882
申请日：2005-09-29
申请人： Robert Hancock , B. Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Rosenberger , Jon-Paul Powers
发明人： Robert Hancock , B. Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Rosenberger , Jon-Paul Powers
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： G01N33/564 , G01N2500/00 , G01N2800/26
摘要： The present invention provides a method of identifying agents that enhance innate immunity in a subject. The invention further provides a method of selectively supresses sepsis by suppressing expression of a proinflammatory gene while maintaining expression of an anti-inflammatory gene. Also provided are methods of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described, methods of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response, and compounds and agents identified by the methods of the invention.
摘要翻译： 本发明提供一种识别增强受试者中先天免疫力的药剂的方法。 本发明还提供了一种通过抑制促炎基因的表达同时保持抗炎基因的表达来选择性抑制败血症的方法。 还提供了鉴定由一种或多种败血症或炎性诱导剂调节并被肽抑制的多核苷酸的多核苷酸或图案的方法，描述了鉴定抑制炎性或败血病应答的多核苷酸表达模式的方法，以及化合物和 通过本发明的方法鉴定的试剂。
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公开(公告)号：US20070134261A1
公开(公告)日：2007-06-14
申请号：US11400411
申请日：2006-04-07
申请人： Robert Hancock , B. Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Rosenberger , Jon-Paul Steven Powers , Jie Yu , Neeloffer Mookherjee
发明人： Robert Hancock , B. Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Rosenberger , Jon-Paul Steven Powers , Jie Yu , Neeloffer Mookherjee
CPC分类号： A61K38/10 , A61K38/1709 , A61K38/193 , C07K7/08 , C07K14/4723 , C07K14/521 , C07K14/7158 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5047 , G01N33/505 , G01N33/564 , G01N2500/00 , G01N2800/26 , A61K2300/00
摘要： The present invention provides a method of identifying agents that enhance innate immunity in a subject. The invention further provides a method of selectively supressing sepsis by suppressing expression of a proinflammatory gene while maintaining expression of an anti-inflammatory gene. Also provided are methods of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described, methods of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response, and compounds and agents identified by the methods of the invention.
摘要翻译： 本发明提供一种识别增强受试者中先天免疫力的药剂的方法。 本发明还提供了通过抑制促炎基因的表达同时保持抗炎基因的表达来选择性抑制败血症的方法。 还提供了鉴定由一种或多种败血症或炎性诱导剂调节并被肽抑制的多核苷酸的多核苷酸或图案的方法，描述了鉴定抑制炎性或败血病应答的多核苷酸表达模式的方法，以及化合物和 通过本发明的方法鉴定的试剂。
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公开(公告)号：US07507787B2
公开(公告)日：2009-03-24
申请号：US10308905
申请日：2002-12-02
申请人： Robert E. W. Hancock , B. Brett Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Melissa Rosenberger , Jon-Paul Steven Powers
发明人： Robert E. W. Hancock , B. Brett Finlay , Monisha Gough Scott , Dawn Bowdish , Carrie Melissa Rosenberger , Jon-Paul Steven Powers
CPC分类号： A61K38/1709 , A61K38/10 , A61K38/193 , C07K7/08 , C07K14/4723 , C07K14/521 , C07K14/7158 , C12Q1/6883 , C12Q2600/158 , G01N33/505 , A61K2300/00
摘要： A method of identifying a polynucleotide or pattern of polynucleotides regulated by one or more sepsis or inflammatory inducing agents and inhibited by a peptide is described. A method of identifying a pattern of polynucleotide expression for inhibition of an inflammatory or septic response. The method includes contacting cells with LPS, LTA, CpG DNA and/or intact microbe or microbial components in the presence or absence of a cationic peptide; detecting a pattern of polynucleotide expression for the cells in the presence and absence of the peptide, wherein the pattern in the presence of the peptide represents inhibition of an inflammatory or septic response. Also included are compounds and agents identified by the methods of the invention. In another aspect, the invention provides methods and compounds for enhancing innate immunity in a subject.
摘要翻译： 描述了鉴定由一种或多种脓毒症或炎性诱导剂调节并被肽抑制的多核苷酸的多核苷酸或图案的方法。 鉴定抑制炎性或败血症反应的多核苷酸表达模式的方法。 该方法包括在存在或不存在阳离子肽的情况下使细胞与LPS，LTA，CpG DNA和/或完整的微生物或微生物组分接触; 在存在和不存在肽的情况下检测细胞的多核苷酸表达的模式，其中在肽存在下的图案表示炎症或败血病应答的抑制。 还包括通过本发明的方法鉴定的化合物和试剂。 另一方面，本发明提供用于增强受试者的先天免疫力的方法和化合物。
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