公开(公告)号：US5482712A

公开(公告)日：1996-01-09

申请号：US309482

申请日：1994-09-22

申请人： Moon H. Kim ,  Chan K. Park ,  Oh H. Kwon

发明人： Moon H. Kim ,  Chan K. Park ,  Oh H. Kwon

IPC分类号： A61K36/00 ,  A61J3/00 ,  A61K31/70 ,  A61K36/234 ,  A61K36/284 ,  A61K36/48 ,  A61K36/482 ,  A61K36/488 ,  A61K36/534 ,  A61K36/734 ,  A61K36/8998 ,  A61K36/9064 ,  A61P3/00 ,  A61P25/32 ,  A61P39/02 ,  A61K35/78

CPC分类号： A61K36/734 ,  A61K36/234 ,  A61K36/284 ,  A61K36/48 ,  A61K36/482 ,  A61K36/488 ,  A61K36/534 ,  A61K36/8998 ,  A61K36/9064 ,  Y10S514/811

摘要： The galenic composition of this invention has been found to possess valuable pharmacological properties in the prevention and treatment of the aftereffects related to ingesting excessive amount of ethanol. The inventive composition decreases blood alcohol concentration by stimulating the alcohol metabolism and reduces the increased content of neutral fat in the blood due to alcohol intake. The composition comprises puerariae radix, phaseoli radiati semen, small red bean, crataegi fructus, malt, cnidii rhizoma, atractylodes rhizoma, cassiae semen, amomi semen, menthae folium and fructose. In the galenic composition of the present invention puerariae radix, phaseoli radiati semen, small red bean, crataegi fructus, malt, cnidii rhizoma, atractylodes rhizoma, cassiae semen, amomi semen, menthae folium and fructose is present preferably in the weight ratio of 20-50:20-50:20-50: 10-25:10-25:10-25:10-25:10-25:3-7:1-5:200-300, respectively.

摘要翻译： 已经发现本发明的盖仑组合物在预防和治疗与摄取过量乙醇有关的后遗症方面具有有价值的药理学特性。 本发明的组合物通过刺激酒精代谢而降低血液酒精浓度，并减少由于酒精摄入引起的血液中的中性脂肪含量的增加。 该组合物包括葛根，相位辐射精液，小红豆，青us，麦芽，枸杞，白术，肉桂精液，amomi精液，薄荷叶和果糖。 在本发明的盖仑组合物中，优选以20重量％的重量比存在葛根，枸杞子，小红豆，枸杞，麦芽，ii ii，白术，桂皮精，阿米米精，薄荷叶和果糖， 50：20-50：20-50：10-25：10-25：10-25：10-25：10-25：3-7：1-5：200-300。

公开(公告)号：US5196356A

公开(公告)日：1993-03-23

申请号：US874612

申请日：1992-04-27

申请人： Tae Y. Won ,  Moon H. Kim ,  Kwang D. Yoo ,  Ji H. Yoo

发明人： Tae Y. Won ,  Moon H. Kim ,  Kwang D. Yoo ,  Ji H. Yoo

IPC分类号： H01L27/06 ,  H01L21/8249

CPC分类号： H01L21/8249 ,  Y10S148/009

摘要： A method for BICMOS devices is disclosed, wherein an emitter and a base of a vertical PNP transistor are self-aligned, an extrinsic base is formed by adapting a base electrode polysilicon layer as a diffusion source, and the base electrode and an intrinsic base are coupled by diffusion of N type impurities adapting the N.sup.+ polysilicon as a diffusion source, so that the manufacturing process is simplified and the resistance of the extrinsic base is reduced.

摘要翻译： 公开了一种用于BICMOS器件的方法，其中垂直PNP晶体管的发射极和基极是自对准的，通过使基极多晶硅层适应扩散源形成非本征基极，并且基极和本征基极 通过使N型多晶硅适应扩散源的N型杂质的扩散耦合，使得制造工艺简化，并且外部基极的电阻降低。

公开(公告)号：US5498615A

公开(公告)日：1996-03-12

申请号：US277602

申请日：1994-07-20

申请人： Wan J. Kim ,  Tae H. Park ,  Moon H, Kim ,  Tae S. Lee ,  Keun S. Nam

发明人： Wan J. Kim ,  Tae H. Park ,  Moon H, Kim ,  Tae S. Lee ,  Keun S. Nam

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K31/405 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention relates to novel quinolone carboxylic acid derivatives having useful antibacterial activities of formula (I): ##STR1## wherein, R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group optionally substituted with an amino or a hydroxy group;R.sub.4 is hydrogen atom, a lower alkyl, benzyl, t-butoxycarbonyl or ethoxycarbonyl group;R.sub.5 is hydrogen, chlorine atom, methyl or an amino group;R.sub.6 is a lower alkyl group, or a cyclopropyl or a phenyl group optionally substituted with a halogen atom; andX is a methyne group optionally substituted with a lower alkyl or a lower alkoxy group or a halogen atom, and pharmaceutically acceptable salts thereof, and processes for preparing these compounds. The present invention also relates to novel intermediates which are useful for preparing the quinolone compounds of the invention.

摘要翻译： 本发明涉及具有式（I）的有用抗菌活性的新型喹诺酮羧酸衍生物：其中R1，R2和R3可以相同或不同，分别为氢或卤素原子 或任选被氨基或羟基取代的低级烷基; R4是氢原子，低级烷基，苄基，叔丁氧基羰基或乙氧基羰基; R5是氢，氯原子，甲基或氨基; R6是低级烷基，或任选被卤素原子取代的环丙基或苯基; X是任选被低级烷基或低级烷氧基或卤素原子取代的甲炔基，以及其药学上可接受的盐，以及这些化合物的制备方法。 本发明还涉及可用于制备本发明的喹诺酮化合物的新型中间体。

公开(公告)号：US5631266A

公开(公告)日：1997-05-20

申请号：US477435

申请日：1995-06-07

申请人： Wan J. Kim ,  Tae H. Park ,  Moon H. Kim ,  Tae S. Lee ,  Keun S. Nam

发明人： Wan J. Kim ,  Tae H. Park ,  Moon H. Kim ,  Tae S. Lee ,  Keun S. Nam

IPC分类号： C07D471/04 ,  A61K31/47 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention relates to quinolone carboxylic acid derivatives having useful antibacterial activities of formula (I): ##STR1## wherein, R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, are each hydrogen or a halogen atom, or a lower alkyl group optionally substituted with an amino or a hydroxy group;R.sub.4 is hydrogen atom, a lower alkyl, benzyl, t-butoxycarbonyl or ethoxycarbonyl group;R.sub.5 is hydrogen, chlorine atom, methyl or an amino group;R.sub.6 is a lower alkyl group, or a cyclopropyl or a phenyl group optionally substituted with a halogen atom; andX is nitrogen atom, or a methyne group optionally substituted with a lower alkyl or a lower alkoxy group or a halogen atom, and pharmaceutically acceptable salts thereof, and processes for preparing these compounds. The present invention also relates to novel intermediates which are useful for preparing the quinolone compounds of the invention.

摘要翻译： 本发明涉及具有式（I）的有用抗菌活性的喹诺酮羧酸衍生物：其中R1，R2和R3可以相同或不同，分别为氢或卤素原子， 或任选被氨基或羟基取代的低级烷基; R4是氢原子，低级烷基，苄基，叔丁氧基羰基或乙氧基羰基; R5是氢，氯原子，甲基或氨基; R6是低级烷基，或任选被卤素原子取代的环丙基或苯基; X为氮原子或任选被低级烷基或低级烷氧基或卤素原子取代的甲炔基，及其药学上可接受的盐，以及制备这些化合物的方法。 本发明还涉及可用于制备本发明的喹诺酮化合物的新型中间体。

公开(公告)号：US5324516A

公开(公告)日：1994-06-28

申请号：US975168

申请日：1992-11-16

申请人： Un H. Pek ,  Moon H. Kim ,  Sung K. Hwang ,  Chan K. Park ,  Oh H. Kwon

发明人： Un H. Pek ,  Moon H. Kim ,  Sung K. Hwang ,  Chan K. Park ,  Oh H. Kwon

IPC分类号： A61K36/00 ,  A61K36/28 ,  A61K36/48 ,  A61K36/539 ,  A61K36/88 ,  A61K35/78

CPC分类号： A61K36/00 ,  A61K36/28 ,  A61K36/48 ,  A61K36/88 ,  Y10S514/811

摘要： The galenic composition of this invention has been found to possess valuable pharmacological properties in the prevention of the aftereffects related to ingesting excessive amounts of ethanol. The inventive composition decreases blood alcohol concentration and reduces the increased content of neutral fat in the blood due to alcohol intake. The composition comprises an amount of fructose and an aqueous extract of pueraria flower, phaseoli radiati semen and pinelliae tuber sufficient to increase, in vivo, metabolic activity of alcohol dehydrogenase and aldehyde dehydrogenase enzymes and a pharmaceutically acceptable carrier, adjuvant or excipient therefor. A method of treating the aftereffects of ingesting excessive amounts of ethanol is also disclosed.

摘要翻译： 已经发现本发明的盖仑组合物在预防与摄取过量乙醇有关的后遗症方面具有有价值的药理学性质。 本发明的组合物降低血液酒精浓度，并减少由于酒精摄取引起的血液中的中性脂肪含量的增加。 组合物包含一定量的果糖和葛根花的水提取物，相位辐射精液和足以在体内增加醇脱氢酶和醛脱氢酶的代谢活性及其药学上可接受的载体，佐剂或赋形剂。 还公开了一种处理摄取过量乙醇的后果的方法。