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1.发明授权公开(公告)号：US09080144B2
公开(公告)日：2015-07-14
申请号：US13890613
申请日：2013-05-09
CPC分类号： C12N5/0006 , A61K8/14 , A61K8/981 , A61K2800/10 , A61K2800/805 , A61Q19/00 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present application describes compounds, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. The present application also describes various uses of these modified liposomes including for tethering the chemoselective and bio-orthogonal complementary functional groups from cell surfaces by liposome delivery toward the goal of rewiring the cell surface.
摘要翻译： 本申请描述了将化学选择性和生物正交互补官能团掺入脂质体中的化合物，组合物和方法。 本申请还描述了这些修饰的脂质体的各种用途，包括通过脂质体递送将细胞表面的化学选择性和生物正交互补官能团连接到重新接线细胞表面的目的。
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公开(公告)号：US20160206748A1
公开(公告)日：2016-07-21
申请号：US14972782
申请日：2015-12-17
IPC分类号： A61K47/48 , A61K31/4188
CPC分类号： A61K47/54 , A61K47/551
摘要： Methods of conjugating two molecules are disclosed herein in which a non-polymeric aliphatic dialdehyde or non-polymeric aromatic dialdehyde is reacted with a compound comprising an amine (NH2) moiety to form a stable product under mild conditions.
摘要翻译： 本文公开了共轭两种分子的方法，其中非聚合脂族二醛或非聚合芳族二醛与包含胺（NH 2）部分的化合物反应以在温和条件下形成稳定的产物。
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公开(公告)号：US09968683B2
公开(公告)日：2018-05-15
申请号：US14972782
申请日：2015-12-17
IPC分类号： C07D211/90 , C07D213/82 , C07D211/82 , A61K47/48 , A61K47/54 , A61K47/55
CPC分类号： A61K47/54 , A61K47/551
摘要： Methods of conjugating two molecules are disclosed herein in which a non-polymeric aliphatic dialdehyde or non-polymeric aromatic dialdehyde is reacted with a compound comprising an amine (NH2) moiety to form a stable product under mild conditions.
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4.发明授权公开(公告)号：US10017460B2
公开(公告)日：2018-07-10
申请号：US14896069
申请日：2014-06-11
IPC分类号： A61K9/127 , C07C235/20 , C12N5/00 , C07F9/50 , C07C43/14 , C07C217/08 , C07C323/12 , C07C239/20 , C07C243/14 , C07C247/04 , C07D495/04 , C07D207/46 , C07C50/28 , C07D307/60 , C07F9/40 , C07C43/172 , C07C49/175 , C12N15/88
CPC分类号： C07C235/20 , A61K9/127 , C07C43/14 , C07C43/172 , C07C49/175 , C07C50/28 , C07C217/08 , C07C239/20 , C07C243/14 , C07C247/04 , C07C323/12 , C07C2601/10 , C07D207/46 , C07D307/60 , C07D495/04 , C07F9/4084 , C07F9/5022 , C12N5/0006 , C12N15/88
摘要： The present application describes amphiphatic compounds like compound IIa below, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. Such compounds are incorporated in greater numbers in liposome and fused cell surfaces, leading to greater adhesion and conjugation efficiency. The present application also describes various uses of these modified liposomes including for tethering the chemoselective and bioorthogonal complementary functional groups from cell surfaces by liposome delivery toward the goal of rewiring the cell surface.
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5.发明申请公开(公告)号：US20130302891A1
公开(公告)日：2013-11-14
申请号：US13890613
申请日：2013-05-09
IPC分类号： C12N5/00
CPC分类号： C12N5/0006 , A61K8/14 , A61K8/981 , A61K2800/10 , A61K2800/805 , A61Q19/00 , C07K2317/24 , C07K2317/31 , C07K2317/569 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present application describes compounds, compositions and methods for incorporating chemoselective and bio-orthogonal complementary functional groups into liposomes. The present application also describes various uses of these modified liposomes including for tethering the chemoselective and bio-orthogonal complementary functional groups from cell surfaces by liposome delivery toward the goal of rewiring the cell surface.
摘要翻译： 本申请描述了将化学选择性和生物正交互补官能团掺入脂质体中的化合物，组合物和方法。 本申请还描述了这些修饰的脂质体的各种用途，包括通过脂质体递送将细胞表面的化学选择性和生物正交互补官能团连接到重新接线细胞表面的目的。
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