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1.发明授权公开(公告)号：US09169326B2
公开(公告)日：2015-10-27
申请号：US13012679
申请日：2011-01-24
CPC分类号： C07K16/3076 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07H21/04 , C07K16/303 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/32 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732
摘要： The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.
摘要翻译： 本发明提供了与人结肠直肠癌和胰腺癌相关抗原（CPAA）结合的纯化的或高度纯的重组单克隆抗体以及编码抗体链的核酸序列，以及对应于所述核酸的氨基酸序列，并且用于 说序列。
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公开(公告)号：US20120034227A1
公开(公告)日：2012-02-09
申请号：US13011485
申请日：2011-01-21
申请人： Myron Arlen , Kwong Tsang
发明人： Myron Arlen , Kwong Tsang
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K16/303 , A61K39/39558 , A61K47/6859 , A61K49/04 , A61K49/16 , A61K49/221 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , G01N33/57438 , G01N2333/705
摘要： The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.
摘要翻译： 本发明涉及单克隆抗体31.1的结合等同物，包括其嵌合和/或人源化形式，抗体片段以及竞争性结合和共同特异性抗体和抗体片段在治疗胰腺癌中的用途。
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公开(公告)号：US20110165599A1
公开(公告)日：2011-07-07
申请号：US13011631
申请日：2011-01-21
申请人： Myron ARLEN , Kwong TSANG
发明人： Myron ARLEN , Kwong TSANG
IPC分类号： A61B6/00 , G01N33/574 , A61B8/00
CPC分类号： C07K16/303 , A61K39/39558 , A61K47/6859 , A61K49/04 , A61K49/16 , A61K49/221 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , G01N33/57438 , G01N2333/705
摘要： The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.
摘要翻译： 本发明涉及单克隆抗体31.1的结合等同物，包括其嵌合和/或人源化形式，抗体片段以及竞争性结合和共同特异性抗体和抗体片段在治疗胰腺癌中的用途。
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公开(公告)号：US20060228363A1
公开(公告)日：2006-10-12
申请号：US11234645
申请日：2005-09-22
申请人： Myron Arlen , Kwong Tsang
发明人： Myron Arlen , Kwong Tsang
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/30
CPC分类号： C07K16/303 , A61K39/39558 , A61K47/6859 , A61K49/04 , A61K49/16 , A61K49/221 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , G01N33/57438 , G01N2333/705
摘要： The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.
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5.发明授权Monoclonal antibodies against human colon carcinoma-associated antigens and uses therefor 失效针对人结肠癌相关抗原的单克隆抗体及其用途
公开(公告)号：US5688657A
公开(公告)日：1997-11-18
申请号：US304524
申请日：1994-09-12
申请人： Kwong Y. Tsang , Myron Arlen
发明人： Kwong Y. Tsang , Myron Arlen
IPC分类号： G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K51/10 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/30 , C07K16/46 , C12N15/02 , C12P21/08 , G01N33/574 , G01N33/577
CPC分类号： G01N33/57419 , A61K39/0011 , A61K51/1063 , A61K51/1066 , C07K14/47 , C07K14/705 , C07K16/3046 , A61K38/00 , A61K39/00 , C07K2317/24 , C07K2317/732
摘要： Monoclonal antibodies, in particular 33.28 and 31.1, and chimeric antibodies, in particular mouse/human chimeric Chi #1 specific for glycoprotein antigens of colon carcinoma-associated antigens which are immunogenic in humans, are disclosed. Such antibodies, and fragments and derivatives thereof, are useful in immunodiagnosis and immunotherapy of human colon, breast, and ovarian cancer, and for purification of antigens which can serve as immunotherapeutic agents. Methods of detecting the colon carcinoma-associated antigen in a sample, and methods for treating subjects having colon, breast, and ovarian carcinomas are disclosed.
摘要翻译： 公开了单克隆抗体，特别是33.28和31.1，以及嵌合抗体，特别是针对人类免疫原性的结肠癌相关抗原的糖蛋白抗原特异性小鼠/人嵌合Chi＃1。 这样的抗体及其片段和衍生物可用于人结肠癌，乳腺癌和卵巢癌的免疫诊断和免疫治疗，以及可用作免疫治疗剂的抗原的纯化。 公开了检测样品中结肠癌相关抗原的方法，以及治疗患有结肠癌，乳腺癌和卵巢癌的受试者的方法。
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6.发明授权公开(公告)号：US08535667B2
公开(公告)日：2013-09-17
申请号：US12825022
申请日：2010-06-28
IPC分类号： A61K39/395 , C07K16/18 , G01N33/53 , A61P35/00
CPC分类号： C07K16/3076 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07H21/04 , C07K16/303 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/32 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732
摘要： The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.
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公开(公告)号：US08470326B2
公开(公告)日：2013-06-25
申请号：US13011485
申请日：2011-01-21
申请人： Myron Arlen , Kwong Tsang
发明人： Myron Arlen , Kwong Tsang
IPC分类号： A61K39/395
CPC分类号： C07K16/303 , A61K39/39558 , A61K47/6859 , A61K49/04 , A61K49/16 , A61K49/221 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , G01N33/57438 , G01N2333/705
摘要： The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.
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8.发明授权Identification and development of specific monoclonal antibodies to squamous cell carcinoma 失效鉴定和发展鳞状细胞癌的特异性单克隆抗体公开(公告)号：US07491801B2
公开(公告)日：2009-02-17
申请号：US10363095
申请日：2001-08-28
申请人： Myron Arlen , Kwong Y. Tsang
发明人： Myron Arlen , Kwong Y. Tsang
CPC分类号： C07K16/3007 , A61K2039/505 , C07K16/30 , C07K2317/24 , C07K2317/732 , G01N33/574
摘要： The present invention relates to novel antibodies, antibody fragments and antibody conjugates which display a high degree of selectivity for squamous cell carcinoma antigens including carcinomas of the lung, esophagus and cervix. The present invention relates to both in vivo and in vitro clinical screening methods for diagnosis or prognosis of carcinomas by means of detecting the expression of squamous cell carcinoma antigens in biological samples of the subject using the novel antibodies of the invention. The invention further provides for kits for carrying out the above described screening methods. Additionally, antibody conjugates may be used to efficiently deliver various agents which have anti-tumor effects to the tumor cell. The antibodies of the invention may also be administered to a patient in non-conjugated form to target ADCC to the tumor cell.
摘要翻译： 本发明涉及对包括肺癌，食道癌和子宫颈癌在内的鳞状细胞癌抗原呈现高度选择性的新型抗体，抗体片段和抗体缀合物。 本发明涉及通过使用本发明的新型抗体在受试者的生物样品中检测鳞状细胞癌抗原的表达的体内和体外临床筛查方法来诊断或预后的癌。 本发明还提供了用于实施上述筛选方法的试剂盒。 此外，抗体缀合物可以用于有效地递送对肿瘤细胞具有抗肿瘤作用的各种试剂。 本发明的抗体也可以以非轭合形式施用于靶向ADCC的肿瘤细胞。
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9.发明授权公开(公告)号：US07314622B2
公开(公告)日：2008-01-01
申请号：US11404566
申请日：2006-04-14
IPC分类号： A61K39/00 , A61K39/395 , G01N33/574 , C07K16/00 , C07H21/04
CPC分类号： C07K16/3076 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07H21/04 , C07K16/303 , C07K16/3046 , C07K2317/14 , C07K2317/24 , C07K2317/32 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/565 , C07K2317/73 , C07K2317/732
摘要： The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (CPAA), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.
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公开(公告)号：US09034588B2
公开(公告)日：2015-05-19
申请号：US13011631
申请日：2011-01-21
申请人： Myron Arlen , Kwong Tsang
发明人： Myron Arlen , Kwong Tsang
IPC分类号： G01N33/574 , A61K39/395 , C07K16/30 , A61K39/00
CPC分类号： C07K16/303 , A61K39/39558 , A61K47/6859 , A61K49/04 , A61K49/16 , A61K49/221 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/732 , C07K2319/00 , G01N33/57438 , G01N2333/705
摘要： The present invention relates to the use of binding equivalents of monoclonal antibody 31.1, including chimerized and/or humanized versions thereof, antibody fragments as well as competitively binding and co-specific antibodies and antibody fragments, in the treatment of pancreatic cancer.
摘要翻译： 本发明涉及单克隆抗体31.1的结合等同物，包括其嵌合和/或人源化形式，抗体片段以及竞争性结合和共同特异性抗体和抗体片段在治疗胰腺癌中的用途。
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