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1.发明授权公开(公告)号：US10368846B2
公开(公告)日：2019-08-06
申请号：US15636739
申请日：2017-06-29
IPC分类号： G06K9/00 , A61B10/00 , A61B5/01 , C07K16/28 , C12Q1/6886 , A61B5/00 , G06T7/00 , G06T7/11 , G01N33/574
摘要： What is disclosed is a system and method for classifying the hormone receptor status of malignant tumorous tissue identified in a thermographic image of a breast. One embodiment of the present method involves the following. First, receive thermographic image(s) of both breasts of a patient with a malignant tumorous region and analyzing the image(s) to define a boundary contour of the breast. Then, the breast regions are segment into regions of elevated temperature. A function of first probability mass function Q, ƒ(Q), is determined based on temperatures of pixels within a first segmented region. A function of the second probability mass function P, ƒ(P), is determined based on temperatures of pixels within a second region. A distance measure between the two functions ƒ(Q) and ƒ(P) is calculated and provided to a classifier trained to classify the malignant tissue as hormone receptor positive, and negative otherwise, based on the distance measure.
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公开(公告)号：US20180000461A1
公开(公告)日：2018-01-04
申请号：US15636718
申请日：2017-06-29
发明人： Krithika Venkataramani , Susmija Jabbireddy , Himanshu J. Madhu , Siva Teja Kakileti , Hadonahalli V. Ramprakash
CPC分类号： A61B10/0041 , A61B5/0013 , A61B5/0033 , A61B5/015 , A61B5/4312 , A61B2562/0276 , A61B2576/02 , G06T7/0014 , G06T7/68 , G06T2207/10048 , G06T2207/30068
摘要： What is disclosed is a system and method for breast cancer screening which determines whether hot spots, as seen in a thermal image of both breasts, can be classified as possibly malignant based on a measure of symmetry. A thermographic image of both breasts of a patient is received and analyzed to determine whether there exists, in each of a left breast and a right breast, a hot spot comprising a patch of pixels with an elevated temperature with respect to surrounding tissue. If a hot spot has been identified in each breast then a measure of symmetry comprising a ratio of an area of a smaller hot spot to an area of a larger hot spot is extracted from the thermographic image. The measure of symmetry is provided to a classifier system trained to classify an unclassified hot spot as malignant or non-malignant based on a measure of symmetry.
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3.发明申请公开(公告)号：US20220237781A1
公开(公告)日：2022-07-28
申请号：US17588018
申请日：2022-01-28
IPC分类号： G06T7/00 , G16H15/00 , G06V10/25 , G06V10/82 , G06V10/764
摘要： A system and method for processing values of a subset of numeric features to provide interpretability of the results of a machine learning model, by determining an extent of the contribution of the subset of features towards a predicted class by performing: (i) receiving the thermal image, (ii) obtaining a region of interest in the thermal image of the subject, (iii) extracting a plurality of numeric features associated with the region of interest of the thermal image, (iv) predicting a class, (v) estimate an extent of contribution of the subset of numeric features towards the decision of the first machine learning prediction model (M) and (vi) generate a report that includes a generated discrete values that determines the extent of contribution of the subset of numeric features towards the predicted class.
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公开(公告)号：US10055542B2
公开(公告)日：2018-08-21
申请号：US14668178
申请日：2015-03-25
CPC分类号： G16H30/20 , A61B5/015 , A61B5/4312 , A61B5/743 , G06F19/321 , G06T7/0012 , G06T2200/24 , G06T2207/10048 , G06T2207/20104 , G06T2207/30068
摘要： What is disclosed is a software interface tool for breast cancer screening that is designed for medical professionals to view and analyze suspicious regions for hot spots and hence facilitate a determination of whether identified areas of breast tissue are cancerous. Isotherm maps are constructed at designated temperature resolution. Maps are displayed on the screen. Point & click on the isotherm map can extract temperature values of pixels within the region covered by the isotherm contours. Also provided are isothermic views at different viewing angles which is advantageous for visual detection. Additional functionalities for hotspot selection, cropping, zooming, viewing at different angles, etc. are also enabled by the present software interface. The present software interface further utilizes a tumor detection method which is also disclosed herein.
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5.发明申请公开(公告)号：US20180000462A1
公开(公告)日：2018-01-04
申请号：US15636739
申请日：2017-06-29
CPC分类号： A61B10/0041 , A61B5/00 , A61B5/015 , A61B5/4312 , A61B5/489 , A61B2576/02 , C07K16/2869 , C12Q1/6886 , G01N33/57415 , G06T7/0012 , G06T7/11 , G06T2207/10048 , G06T2207/30068
摘要： What is disclosed is a system and method for classifying the hormone receptor status of malignant tumorous tissue identified in a thermographic image of a breast. One embodiment of the present method involves the following. First, receive thermographic image(s) of both breasts of a patient with a malignant tumorous region and analyzing the image(s) to define a boundary contour of the breast. Then, the breast regions are segment into regions of elevated temperature. A function of first probability mass function Q, ƒ(Q), is determined based on temperatures of pixels within a first segmented region. A function of the second probability mass function P, ƒ(P), is determined based on temperatures of pixels within a second region. A distance measure between the two functions ƒ(Q) and ƒ(P) is calculated and provided to a classifier trained to classify the malignant tissue as hormone receptor positive, and negative otherwise, based on the distance measure.
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公开(公告)号：US10307141B2
公开(公告)日：2019-06-04
申请号：US15636718
申请日：2017-06-29
发明人： Krithika Venkataramani , Susmija Jabbireddy , Himanshu J. Madhu , Siva Teja Kakileti , Hadonahalli V. Ramprakash
摘要： What is disclosed is a system and method for breast cancer screening which determines whether hot spots, as seen in a thermal image of both breasts, can be classified as possibly malignant based on a measure of symmetry. A thermographic image of both breasts of a patient is received and analyzed to determine whether there exists, in each of a left breast and a right breast, a hot spot comprising a patch of pixels with an elevated temperature with respect to surrounding tissue. If a hot spot has been identified in each breast then a measure of symmetry comprising a ratio of an area of a smaller hot spot to an area of a larger hot spot is extracted from the thermographic image. The measure of symmetry is provided to a classifier system trained to classify an unclassified hot spot as malignant or non-malignant based on a measure of symmetry.
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公开(公告)号：US10198670B2
公开(公告)日：2019-02-05
申请号：US15636754
申请日：2017-06-29
发明人： Siva Teja Kakileti
摘要： What is disclosed is a system and method for isolating blood vessels in a thermographic image of a patient's breast or any other muscular region of the body. A thermographic image of a patient is received. A temperature-based analysis is performed on the image to detect vessel pixels. An intensity-based method analysis is performed on the image. A shape-based analysis is also performed to detect pixels of vessel-like structures. Candidate pixels which satisfy one or more of intensity-based or temperature-based or shaped-based criterion are identified. A constraint of local maximallity is thereafter imposed on each candidate pixel that satisfies both criterion to eliminate spurious non-vessel pixels. Candidate pixels which satisfy both criterion are then marked with a different color such that the vessel structures in the breast tissue can be visually differentiated. The vessel structures are provided to a classifier system which classifies the tissue in the thermal image as malignant and non-malignant otherwise, based on a tortuosity of the vessel structures.
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公开(公告)号：US20180005085A1
公开(公告)日：2018-01-04
申请号：US15636754
申请日：2017-06-29
发明人： Siva Teja Kakileti
CPC分类号： G06K9/6267 , A61B5/0075 , A61B5/0077 , A61B5/0091 , A61B5/015 , A61B5/4312 , A61B5/489 , A61B5/7264 , A61B5/7282 , A61B2576/02 , G06K9/00885 , G06K9/4647 , G06K9/6202 , G06K9/6214 , G06K9/6269 , G06K9/6271 , G06K2009/00932 , G06T7/0012 , G06T7/11 , G06T2207/10048 , G06T2207/20021 , G06T2207/20084 , G06T2207/30068 , G06T2207/30096 , G06T2207/30101
摘要： What is disclosed is a system and method for isolating blood vessels in a thermographic image of a patient's breast or any other muscular region of the body. A thermographic image of a patient is received. A temperature-based analysis is performed on the image to detect vessel pixels. An intensity-based method analysis is performed on the image. A shape-based analysis is also performed to detect pixels of vessel-like structures. Candidate pixels which satisfy one or more of intensity-based or temperature-based or shaped-based criterion are identified. A constraint of local maximallity is thereafter imposed on each candidate pixel that satisfies both criterion to eliminate spurious non-vessel pixels. Candidate pixels which satisfy both criterion are then marked with a different color such that the vessel structures in the breast tissue can be visually differentiated. The vessel structures are provided to a classifier system which classifies the tissue in the thermal image as malignant and non-malignant otherwise, based on a tortuosity of the vessel structures.
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公开(公告)号：US20170245762A1
公开(公告)日：2017-08-31
申请号：US15055011
申请日：2016-02-26
CPC分类号： A61B5/0046 , A61B5/0013 , A61B5/0075 , A61B5/0091 , A61B5/015 , A61B5/7405 , A61B5/7475 , A61B34/30 , A61B90/50 , A61B2562/0204 , B25J9/0084 , B25J13/065 , B25J19/023
摘要： What is disclosed is an apparatus for enabling privacy for patients undergoing breast cancer screening in a non-clinical setting. One embodiment of the present apparatus comprises an enclosure in which a person can remove one or more garments to expose their breasts to a thermal camera for breast cancer screening. The enclosure is such that at least the breast area of that person is shielded from view by third parties. The apparatus also comprises a thermal camera for capturing thermal images of the exposed breast area. The thermal camera is connected to a robotic arm that changes the camera angle relative to real-world coordinates so that thermal images can be taken of the breast area from any angle between a frontal view and a left/right lateral view. A processor which executes a software interface tool for semi-automated or automated breast cancer screening based on the thermal images of the breast.
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公开(公告)号：US20240000372A1
公开(公告)日：2024-01-04
申请号：US18009303
申请日：2021-06-03
发明人： Siva Teja Kakileti , GEETHA MANJUNATH , V.N Ratna Kumari T. , Kanchana Gopinath , Himanshu J Madhu
CPC分类号： A61B5/4312 , A61B5/015 , A61B5/7264 , G06T2207/30068 , G16H15/00 , G16H10/60 , G06T2207/10048 , G06T7/0012
摘要： A system and method for a quantitative evaluation of a breast health of a pregnant and lactating woman for clinical management of a breast feeding by performing (i) receiving a thermal image of a breast region of the pregnant and lactating woman, (ii) automatically determine network structures associated with ductal or vascular thermal patterns of the pregnant and lactating woman by analysing the thermal images of the pregnant and lactating woman, (iii) estimate quantitative parameters corresponding to the network structures associated with the ductal or vascular thermal patterns using the machine learning model and (iv) generate a breast health report with the estimated quantitative parameters and the schematics of vascular network to enable clinical management of breastfeeding.
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