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    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF
    1.
    发明申请
    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF 有权

    公开(公告)号：US20220241408A1

    公开(公告)日：2022-08-04

    申请号：US17477739

    申请日：2021-09-17

    Applicant: Novavax AB

    Inventor： Bror MOREIN ,  Karin LÖVGREN BENGTSSON ,  Jill EKSTRÖM ,  Katarina RANLUND ,  Kefei HU

    IPC: A61K39/39

    Abstract: Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, block polymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A, CpG variants, CT and LT or fractions thereof.

    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF
    2.
    发明申请
    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF 审中-公开

    公开(公告)号：US20200345840A1

    公开(公告)日：2020-11-05

    申请号：US16701948

    申请日：2019-12-03

    Applicant: Novavax AB

    Inventor： Bror MOREIN ,  Karin LÖVGREN BENGTSSON ,  Jill EKSTRÖM ,  Katarina RANLUND ,  Kefei HU

    IPC: A61K39/39

    Abstract: Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, block polymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A, CpG variants, CT and LT or fractions thereof.

    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF
    3.
    发明申请
    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF 审中-公开
    QU WITH。WITH。。。。。。。。。。。。。。。。。。。

    公开(公告)号：US20140335049A1

    公开(公告)日：2014-11-13

    申请号：US14445690

    申请日：2014-07-29

    Applicant: Novavax AB

    Inventor： Bror Morein ,  Karin Lövgren Bengtsson ,  Jill Ekström ,  Katarina Ranlund ,  Kefei Hu

    IPC: A61K39/39

    CPC classification number: A61K39/39 ,  A61K2039/55577 ,  A61K2039/57

    Abstract: Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, block polymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A, CpG variants, CT and LT or fractions thereof.

    Abstract translation: Quil A的组分A可与至少一种其它佐剂一起用于制备佐剂组合物，其中所含的佐剂组分协同作用以增强免疫应答水平，并对共同施用的抗原或免疫原具有协同的免疫调节活性。 其他佐剂可以包含皂苷，天然存在的，合成的或半合成的皂苷分子; 例如 来自Quil A，细胞壁骨架，嵌段聚合物，TDM，脂肽，LPS和LPS衍生物的皂苷和皂苷级分，来自不同细菌种类及其衍生物的脂质A，例如单磷酰脂质A，CpG变体，CT和LT或其部分 。

    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF
    5.
    发明公开
    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF 审中-公开

    公开(公告)号：US20240024468A1

    公开(公告)日：2024-01-25

    申请号：US18376666

    申请日：2023-10-04

    Applicant: Novavax AB

    Inventor： Bror MOREIN ,  Karin LÖVGREN BENGTSSON ,  Jill EKSTRÖM ,  Katarina RANLUND ,  Kefei HU

    IPC: A61K39/39

    CPC classification number: A61K39/39 ,  A61K2039/57

    Abstract: Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, block polymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A, CpG variants, CT and LT or fractions thereof.

    Influenza vaccine
    8.
    发明授权
    Influenza vaccine 有权

    公开(公告)号：US10736958B2

    公开(公告)日：2020-08-11

    申请号：US16260557

    申请日：2019-01-29

    Applicant: Novavax AB

    Inventor： Albertus D. M. E. Osterhaus ,  Bror Morein ,  Karin Lovgren Bengtsson

    IPC: A61K39/145 ,  A61K39/12 ,  A61K39/00

    Abstract: The present invention relates to a composition comprising at least one ISCOM complex and at least one ectodomain from at least one hemagglutinin (HA) domain and at least one ectodomain from at least one neuraminidase (NA) domain from one or more influenza virus, wherein the extodomains represent ectodomains isolated from the influenza virus. The invention also regards a kit. The composition may be used as an immune stimulating medicine, immune modulating pharmaceutical or a vaccine e.g. against influenza for vertebrates, e.g. birds and mammals.

    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF
    10.
    发明申请
    QUIL A FRACTION WITH LOW TOXICITY AND USE THEREOF 审中-公开

    公开(公告)号：US20160184427A1

    公开(公告)日：2016-06-30

    申请号：US15054801

    申请日：2016-02-26

    Applicant: NOVAVAX AB

    Inventor： Bror Morein ,  Karin Lövgren Bengtsson ,  Jill Ekström ,  Katarina Ranlund ,  Kefei Hu

    IPC: A61K39/39

    CPC classification number: A61K39/39 ,  A61K2039/55577 ,  A61K2039/57

    Abstract: Fraction A of Quil A can be used together with at least one other adjuvant for the preparation of an adjuvant composition, where the included adjuvant components act synergistically to enhance level of immune response and have synergistic immunomodulating activity on the co-administered antigens or immunogens. Other adjuvants can comprise saponins, naturally occurring, synthetic or semisynthetic saponin molecules; e.g. saponins and saponin fractions from Quil A, cell wall skeleton, block polymers, TDM, lipopeptides, LPS and LPS-derivatives, Lipid A from different bacterial species and derivatives thereof, e.g., monophosphoryl lipid A, CpG variants, CT and LT or fractions thereof.

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