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公开(公告)号：US5954748A
公开(公告)日：1999-09-21
申请号：US680387
申请日：1996-07-15
CPC分类号： A61L17/08 , A61B17/06166 , A61L17/145 , A61B17/06128 , A61B17/06133
摘要： A catgut suture includes a cross linked gelatin coating which is substantially insoluble in tubing or storage solution. The gelatin coating is formed by immersing the gut suture in aqueous gelatin solution, fixing the gelatin in a solution of cross linking agent such as glutaraldehyde, buffering the coating, then drying the suture at a temperature of at least about 50.degree. C.
摘要翻译： 肠肠缝合线包括基本上不溶于管或储存溶液的交联明胶涂层。 通过将肠缝线浸入明胶水溶液中，将明胶固定在交联剂如戊二醛的溶液中，缓冲该涂层，然后在至少约50℃的温度下干燥缝合线，形成明胶涂层。
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公开(公告)号：US5584857A
公开(公告)日：1996-12-17
申请号：US338404
申请日：1994-11-14
CPC分类号： A61B17/06166 , A61L17/08 , A61L17/145
摘要： A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C.sub.2 -C.sub.4 alcohol and a lubricant of fatty acids, fatty acid alcohols and/or triglycerides of fatty acids. Gut sutures coated with the coating composition may be stored or packaged in the tubing fluid to provide sutures with improved flexibility, pliability, run-down performance and superior resistance to fraying and breaking.
摘要翻译： 提供用于缝线的涂层和管道液，特别是肠缝线。 涂料组合物包括亚麻子油，有机溶剂和催化剂。 管道液体包括水，软化剂，C 2 -C 4醇和脂肪酸的润滑剂，脂肪酸醇和/或脂肪酸的甘油三酯。 涂覆有涂料组合物的肠缝线可以储存或包装在管道液体中，以提供具有改善的柔韧性，柔韧性，破坏性能和优异的抗磨损和破裂性能的缝合线。
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公开(公告)号：US5939191A
公开(公告)日：1999-08-17
申请号：US880303
申请日：1997-06-23
IPC分类号： A61L17/08 , A61L17/14 , C08G63/08 , C08G63/64 , C08G63/664 , C09D167/04 , B05D1/36 , A61B17/04
CPC分类号： A61L17/08 , A61L17/145 , C08G63/08 , C08G63/64 , C08G63/664 , C09D167/04 , Y10T428/2933 , Y10T428/2938 , Y10T428/2967
摘要： A gut suture is coated with a bioabsorbable copolymer obtained by polymerizing a major amount of .epsilon.-caprolactone and a minor amount of at least one other copolymerizable monomer in the presence of polyhydric alcohol as initiator. The coated gut suture can be packaged in the absence of conventional tubing fluid, i.e., in the dry state, while at the same time retaining flexibility, pliability and resistance to fray. In an alternative embodiment, a gut suture is coated with a pre-coating composition prior to being coated with the bioabsorbable copolymer.
摘要翻译： 在多元醇作为引发剂的存在下，通过聚合主要量的ε-己内酯和少量的至少一种其它可共聚单体获得的生物可吸收共聚物涂布肠缝合线。 涂覆的肠缝合线可以在不存在常规管道流体的情况下被包装，即处于干燥状态，同时保持柔韧性，柔韧性和抗磨损性。 在替代实施例中，在用生物可吸收共聚物涂覆之前，用预涂组合物涂覆肠缝合线。
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公开(公告)号：US5236444A
公开(公告)日：1993-08-17
申请号：US966948
申请日：1992-10-27
摘要： Block copolymers have a first polymer block wherein glycolide is the predominant component and a second block having glycolide, lactide and trimethylene carbonate linkages. The copolymers are useful in forming surgical devices, including monofilament sutures.
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公开(公告)号：US5891167A
公开(公告)日：1999-04-06
申请号：US668024
申请日：1996-06-19
CPC分类号： A61L17/08 , A61B17/06128 , A61B17/06133 , A61L17/145 , A61B17/06166
摘要： A catgut suture includes a dehydrothermal cross-linked collagen coating which is insoluble in tubing solution. The collagen coating is formed by immersing the gut suture in a solution of collagen in acidified water. Optionally, a plasticizer may be included in the coating solution. The suture is then heated in a vacuum to effect cross-linking of the collagen.
摘要翻译： 肠道缝合线包括不溶于管道溶液的脱水热交联胶原涂层。 通过将肠缝线浸入胶原蛋白溶液在酸化水中而形成胶原蛋白。 任选地，可以在涂布溶液中包含增塑剂。 然后将缝合线在真空中加热以实现胶原蛋白的交联。
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公开(公告)号：US5584858A
公开(公告)日：1996-12-17
申请号：US339372
申请日：1994-11-14
CPC分类号： A61L17/08 , A61B17/06166 , A61L17/145
摘要： A coating and tubing fluid for sutures, especially gut sutures, is provided. The coating composition includes linseed oil, an organic solvent and a catalyst. The tubing fluid includes water, a softening agent, a C.sub.2 -C.sub.4 alcohol and a lubricant of fatty acids, fatty acid alcohols and/or triglycerides of fatty acids. Gut sutures coated with the coating composition may be stored or packaged in the tubing fluid to provide sutures with improved flexibility, pliability, run-down performance and superior resistance to fraying and breaking.
摘要翻译： 提供用于缝线的涂层和管道液，特别是肠缝线。 涂料组合物包括亚麻子油，有机溶剂和催化剂。 管道液体包括水，软化剂，C 2 -C 4醇和脂肪酸的润滑剂，脂肪酸醇和/或脂肪酸的甘油三酯。 涂覆有涂料组合物的肠缝线可以储存或包装在管道液体中，以提供具有改善的柔韧性，柔韧性，破坏性能和优异的抗磨损和破裂性能的缝合线。
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公开(公告)号：US5312437A
公开(公告)日：1994-05-17
申请号：US896856
申请日：1992-06-12
CPC分类号： A61L17/145 , Y10T428/2933 , Y10T428/2938
摘要： An absorbable composition for application to a surgical suture to improve the knot tie-down and/or knot security characteristics thereof is obtained from the reaction of a poly(oxypropylene) glycol and a lactide/glycolide copolymer, optionally, in the presence of an initiator and/or catalyst.
摘要翻译： 一种用于外科缝合线以改善其结扎和/或结点安全性的可吸收组合物可从聚氧化丙烯与丙交酯/乙交酯共聚物的反应中获得，任选地，在引发剂存在下 和/或催化剂。
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公开(公告)号：US5607686A
公开(公告)日：1997-03-04
申请号：US343389
申请日：1994-11-22
IPC分类号： A61L27/26 , A61L27/50 , A61L31/04 , A61L31/14 , C08L101/00 , A61L25/00 , A61K47/34 , A61K47/36
CPC分类号： A61L31/14 , A61L27/26 , A61L27/50 , A61L31/041 , C08L101/00
摘要： A polymeric composition for use in medicine includes a hydrophobic bioabsorbable polymer admixed with a hydrophilic liquid polymer wherein the polymeric composition undergoes macroscopic phase separation on contact with aqueous media. The polymeric composition optionally includes a medicinal agent. The polymeric composition may be deposited as a permeable, semipermeable or occlusive irregular mass, regular mass, film or foam over a suitable surface such viable body tissue. Bioabsorbable implants formed from the polymeric composition may assume a variety of three dimensional configurations such as planar, spherical, cylindrical, rectangular and polygonal.
摘要翻译： 用于医药的聚合物组合物包括与亲水性液体聚合物混合的疏水性生物可吸收聚合物，其中聚合物组合物在与水性介质接触时经历宏观相分离。 聚合物组合物任选地包括药剂。 可以将聚合物组合物作为可渗透的，半渗透的或闭塞的不规则团块，规则的质量，膜或泡沫沉积在合适的表面上，这样的活体组织。 由聚合物组合物形成的生物可吸收植入物可呈现各种三维构型，例如平面，球形，圆柱形，矩形和多边形。
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公开(公告)号：US5478921A
公开(公告)日：1995-12-26
申请号：US295977
申请日：1994-08-25
CPC分类号： C08G63/90 , C08F6/005 , Y02P20/544
摘要： A method for purifying a material containing a bioabsorbable polymer involves contacting the polymer with an extractant under supercritical conditions of temperature and pressure to extract residual impurities from the polymer and thereafter recovering the purified polymer. The method sharply reduces residual monomer levels in bioabsorbable polymers without altering polymer viscosity or melting point.
摘要翻译： 用于纯化含有生物可吸收聚合物的材料的方法包括在超临界温度和压力条件下使聚合物与萃取剂接触以从聚合物中提取残余杂质，然后回收纯化的聚合物。 该方法大大降低了生物可吸收聚合物中的残留单体水平，而不改变聚合物粘度或熔点。
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10.发明授权Method for improving the in vivo strength retention of a bioabsorbable implantable medical device and resulting medical device 失效用于改善生物可吸收的可植入医疗装置和所产生的医疗装置的体内强度保持的方法
公开(公告)号：US5478355A
公开(公告)日：1995-12-26
申请号：US367754
申请日：1994-12-30
CPC分类号： A61L27/18 , A61B17/06166 , A61L17/10 , A61L31/06 , A61B2017/0023
摘要： A method is provided for improving the in vivo strength retention of a bioabsorbable implantable medical device such as a suture.
摘要翻译： 提供了一种用于改善生物可吸收的可植入医疗装置例如缝合线的体内强度保留的方法。
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