公开(公告)号：US5158071A

公开(公告)日：1992-10-27

申请号：US373264

申请日：1989-06-27

申请人： Shinichiro Umemura ,  Nagahiko Yumita ,  Koshiro Umemura ,  Kageyoshi Katakura

发明人： Shinichiro Umemura ,  Nagahiko Yumita ,  Koshiro Umemura ,  Kageyoshi Katakura

IPC分类号： A61B17/22 ,  A61B18/00 ,  A61F7/00 ,  A61N7/00

CPC分类号： A61M37/0092 ,  A61N7/00 ,  A61N7/02 ,  A61B2017/22008 ,  A61B2017/22028 ,  A61B2017/22088 ,  A61N2007/006 ,  A61N2007/0078 ,  A61N2007/0095 ,  A61N2007/027

摘要： An ultrasonic apparatus for thereapeutical use, especially for remedying a malignant tumor, through activation of a drug at a desired local portion inside of a living body by sequentially irradiating a plurality kinds of convergent ultrasonic waves having different focal positions of different acoustic pressure distribution shapes but having a mutually overlapping focal zone and by switching them within a short period. The drug is activated as a promotor for an ultrasonic therapeutical effect through continuous generation and rupture of cavitation caused by the irradiated and switched ultrasonic waves.

公开(公告)号：US4971991A

公开(公告)日：1990-11-20

申请号：US274109

申请日：1988-11-21

申请人： Kohshiro Umemura ,  Ryuichiro Nishigaki ,  Nagahiko Yumita

发明人： Kohshiro Umemura ,  Ryuichiro Nishigaki ,  Nagahiko Yumita

IPC分类号： A61B17/22 ,  A61B18/00 ,  A61K31/40 ,  A61K41/00 ,  A61K45/00 ,  A61M37/00 ,  A61P35/00

CPC分类号： A61K41/0052 ,  A61K31/40 ,  A61K41/0028 ,  A61M37/0092 ,  A61B2017/22008

摘要： Physiological function-enhancing agents to be used for the treatment of tumors comprise a compound capable of stimulating the generation of at least one type of active oxygen, such as superoxide radicals and singlet oxygen, upon ultrasonic irradiation (e.g., porphyrins, chlorins, methylene-blue, fluorescein, acridine derivatives, rhodamines and tetracyclines).Irradiating ultrasonic waves onto tumor tissues, with this agent orally or parenterally administered in advance, causes the active ingredient present at the irradiated site to generate active oxygen (e.g., superoxide radicals and singlet oxygen), which serves to destruct the tumor cells.These agents are very low in toxicity and exhibit antitumor activity only upon ultrasonic irradiation. Hence, there is no risk of causing any systemic idsorder. In addition, these act exclusively upon tumor tissues when combined with ultrasonic irradiation, with no adverse effect upon normal tissues.

摘要翻译： 用于治疗肿瘤的生理功能增强剂包括能够刺激在超声照射下产生至少一种类型的活性氧（例如超氧自由基和单线态氧）的化合物（例如，卟啉，二氢卟酚，亚甲基 - 蓝色，荧光素，吖啶衍生物，罗丹明和四环素）。 预先通过口服或肠胃外给药将肿瘤组织超声波照射到肿瘤组织上，导致存在于照射部位的活性成分产生用于破坏肿瘤细胞的活性氧（例如超氧自由基和单线态氧）。 这些药剂的毒性非常低，仅在超声波照射时才具有抗肿瘤活性。 因此，没有引起任何系统性疾病的风险。 此外，当与超声波照射组合时，它们仅在肿瘤组织上起作用，对正常组织没有不利影响。