公开(公告)号：US20060088481A1

公开(公告)日：2006-04-27

申请号：US11131448

申请日：2005-05-17

申请人： Narayan Athanikar ,  Scott Gubler

发明人： Narayan Athanikar ,  Scott Gubler

IPC分类号： A61K8/19 ,  A61K31/29 ,  A61K31/70

CPC分类号： A61Q17/005 ,  A61K8/19 ,  A61K8/365 ,  A61K8/42 ,  A61K8/49 ,  A61K8/494 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/676 ,  A61K8/88 ,  A61K8/97 ,  A61K9/0058 ,  A61K31/28 ,  A61K31/29 ,  A61K31/43 ,  A61K31/44 ,  A61K31/485 ,  A61K31/7135 ,  A61K33/245 ,  A61K38/164 ,  A61K45/06 ,  A61Q11/00 ,  A61Q19/00 ,  Y10S514/90 ,  Y10S514/902 ,  A61K2300/00

摘要： Topical oral dosage forms containing bismuth compounds are described, which are useful for treating H. pylori and other bacterial infections that cause gastrointestinal disorders and halitosis, as well as for treating ocular and dermal wounds. Methods of employing topical oral dosage forms for treating bacterial infections that cause gastrointestinal disorders and halitosis, and for treating ocular and dermal wounds, are also described.

公开(公告)号：US06379651B1

公开(公告)日：2002-04-30

申请号：US09364613

申请日：1999-07-29

申请人： Narayan Athanikar

发明人： Narayan Athanikar

IPC分类号： A61K968

CPC分类号： A61K31/485 ,  A61K8/19 ,  A61K8/365 ,  A61K8/42 ,  A61K8/49 ,  A61K8/494 ,  A61K8/60 ,  A61K8/64 ,  A61K8/66 ,  A61K8/676 ,  A61K8/88 ,  A61K8/97 ,  A61K9/0058 ,  A61K31/28 ,  A61K31/29 ,  A61K31/43 ,  A61K31/44 ,  A61K31/7135 ,  A61K33/245 ,  A61K36/00 ,  A61K38/164 ,  A61K45/06 ,  A61Q11/00 ,  A61Q17/005 ,  Y10S514/925 ,  Y10S514/926 ,  Y10S514/927 ,  Y10S514/928 ,  A61K2300/00

摘要： The invention relates to concomitant treatment with bismuth compounds, other antibacterial compounds, and/or antibiotics in oral-topical and peroral dosage forms to eradicate H. pylori from its niches both in the dental plaque and in the gastric mucosa in order to improve the ulcer cure rate and prevent ulcer relapse. The invention also provides oral topical dosage forms with pharmaceutically usable bismuth compounds, other antibacterial compounds, and/or antibiotics that eradicate or reduce H. pylori in dental plaque. The invention further provides for treatment with bismuth compounds, other antibacterial compounds, and/or antibiotics which are effective against Campylobacter rectus and Treponema denticola which are responsible for causing halitosis. The invention also provides bismuth compounds which have applications in wound healing, particularly in ocular and dermal wound healing.

摘要翻译： 本发明涉及在口腔 - 局部和口服剂型中与铋化合物，其它抗菌化合物和/或抗生素的同时治疗，以从其牙菌斑和胃粘膜中的细菌壁中消除幽门螺杆菌，以改善溃疡 治愈率并预防溃疡复发。 本发明还提供口服局部剂型与药用铋化合物，其它抗细菌化合物和/或抗生素，其消除或减少牙菌斑中的幽门螺杆菌。 本发明进一步提供对负责引起口臭的直肠弯曲杆菌和梅毒螺旋体有效的铋化合物，其它抗细菌化合物和/或抗生素的治疗。 本发明还提供了在伤口愈合中应用的铋化合物，特别是在眼部和皮肤伤口愈合中。