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公开(公告)号：US20120149944A1
公开(公告)日：2012-06-14
申请号：US13256377
申请日：2010-03-15
申请人： Wlodzimierz W. Zmierczak , Jan Dean Miller , Raj Rajamani , Steven Messiter , Nicholas Drinnan , Edward Choros
发明人： Wlodzimierz W. Zmierczak , Jan Dean Miller , Raj Rajamani , Steven Messiter , Nicholas Drinnan , Edward Choros
CPC分类号： B01J8/22 , B01J8/1836 , B01J15/005 , B01J16/005 , B01J19/243 , B01J19/2475 , B01J2208/00203 , B01J2208/00212 , B01J2208/00752 , B01J2208/00911 , B01J2208/00938 , B01J2219/00094 , C07C5/05 , C07C29/154 , C07C41/09 , C07C2523/44 , C07C2531/28 , C10G2/342 , C10G45/00 , C10G50/00 , C10G2300/4081 , C07C11/08 , C07C31/04 , C07C43/04
摘要： A method of reacting compounds can include directing a liquid into a helical constrained flow (37) having an inner circumferential flow surface and an outer circumferential flow surface. The helical constrained flow (37) can be formed around an axial interior volume (38). At least a portion of the helical constrained flow can be exposed to a sparging portion (35) to allow a fluid to be sparged into the liquid along the helical constrained flow (37). The fluid reactant can be sparged through the helical constrained flow so as to form a fluid product.
摘要翻译： 使化合物反应的方法可以包括将液体引导到具有内周流动表面和外周流动表面的螺旋约束流（37）中。 螺旋限制流（37）可围绕轴向内部容积（38）形成。 螺旋限制流的至少一部分可以暴露于鼓泡部分（35），以允许流体沿着螺旋约束流（37）喷射到液体中。 流体反应物可以通过螺旋约束流喷射，以便形成流体产物。
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公开(公告)号：US20060121530A1
公开(公告)日：2006-06-08
申请号：US10513286
申请日：2003-04-24
申请人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
摘要翻译： 描述了用于制备潜在的生物活性二糖化合物的组合文库的方法。 为了改变脂质溶解度大小，这些化合物被多种功能化，起到其它特性的作用，特别是发现新的药物或药物样化合物或具有有用特性的化合物。 本发明提供了关于糖环的各种功能化的二糖的溶液或固相合成的中间体，方法和合成策略，包括添加芳香性和电荷，以及放置药学上有用的基团和等体积体。
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公开(公告)号：US08980196B2
公开(公告)日：2015-03-17
申请号：US13256377
申请日：2010-03-15
申请人： Wlodzimierz W. Zmierczak , Jan Dean Miller , Raj Rajamani , Steven Messiter , Nicholas Drinnan , Edward Choros
发明人： Wlodzimierz W. Zmierczak , Jan Dean Miller , Raj Rajamani , Steven Messiter , Nicholas Drinnan , Edward Choros
IPC分类号： B01J19/24 , B01J8/22 , B01J15/00 , B01J16/00 , C07C5/05 , C07C29/154 , C07C41/09 , C10G2/00 , C10G45/00 , C10G50/00
CPC分类号： B01J8/22 , B01J8/1836 , B01J15/005 , B01J16/005 , B01J19/243 , B01J19/2475 , B01J2208/00203 , B01J2208/00212 , B01J2208/00752 , B01J2208/00911 , B01J2208/00938 , B01J2219/00094 , C07C5/05 , C07C29/154 , C07C41/09 , C07C2523/44 , C07C2531/28 , C10G2/342 , C10G45/00 , C10G50/00 , C10G2300/4081 , C07C11/08 , C07C31/04 , C07C43/04
摘要： A method of reacting compounds can include directing a liquid into a helical constrained flow (37) having an inner circumferential flow surface and an outer circumferential flow surface. The helical constrained flow (37) can be formed around an axial interior volume (38). At least a portion of the helical constrained flow can be exposed to a sparging portion (35) to allow a fluid to be sparged into the liquid along the helical constrained flow (37). The fluid reactant can be sparged through the helical constrained flow so as to form a fluid product.
摘要翻译： 使化合物反应的方法可以包括将液体引导到具有内周流动表面和外周流动表面的螺旋约束流（37）中。 螺旋限制流（37）可围绕轴向内部容积（38）形成。 螺旋限制流的至少一部分可以暴露于鼓泡部分（35），以允许流体沿着螺旋约束流（37）喷射到液体中。 流体反应物可以通过螺旋约束流喷射，以便形成流体产物。
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公开(公告)号：US20050080042A1
公开(公告)日：2005-04-14
申请号：US10488677
申请日：2002-09-06
IPC分类号： C07H15/18 , A61K31/7028 , A61K31/7034 , A61K31/7072 , A61P7/02 , A61P9/10 , C07H3/06 , C07H7/033 , C07H11/00 , C07H15/203 , C07H15/26 , C07H23/00 , A61K31/727 , C07H11/04 , C08B37/10
CPC分类号： C07H9/00 , C07H3/06 , C07H5/04 , C07H7/033 , C07H11/00 , C07H13/04 , C07H13/08 , C07H15/10 , C07H15/18
摘要： Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.
摘要翻译： 制备用于制备合成类肝素的合成单糖，二糖，三糖，四糖和五糖。
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