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公开(公告)号：US20060121530A1
公开(公告)日：2006-06-08
申请号：US10513286
申请日：2003-04-24
申请人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
摘要翻译： 描述了用于制备潜在的生物活性二糖化合物的组合文库的方法。 为了改变脂质溶解度大小，这些化合物被多种功能化，起到其它特性的作用，特别是发现新的药物或药物样化合物或具有有用特性的化合物。 本发明提供了关于糖环的各种功能化的二糖的溶液或固相合成的中间体，方法和合成策略，包括添加芳香性和电荷，以及放置药学上有用的基团和等体积体。
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公开(公告)号：US20110201794A1
公开(公告)日：2011-08-18
申请号：US12926913
申请日：2010-12-17
申请人： Wim Meutermans , Michael L. West , George Adamson , Giang Thanh Le , Nicholas B. Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael L. West , George Adamson , Giang Thanh Le , Nicholas B. Drinnan , Giovani Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
摘要翻译： 描述了用于制备潜在的生物活性二糖化合物的组合文库的方法。 为了改变脂质溶解度大小，这些化合物被多种功能化，起到其它特性的作用，特别是发现新的药物或药物样化合物或具有有用特性的化合物。 本发明提供了关于糖环的各种功能化的二糖的溶液或固相合成的中间体，方法和合成策略，包括添加芳香性和电荷，以及放置药学上有用的基团和等体积体。
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公开(公告)号：US07875707B2
公开(公告)日：2011-01-25
申请号：US10513286
申请日：2003-04-24
申请人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas B. Drinnan , Giovanni Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
发明人： Wim Meutermans , Michael West , George Adamson , Giang Thanh Le , Nicholas B. Drinnan , Giovanni Abbenante , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam , Gerald Tometzki
IPC分类号： C07H1/00 , C07H15/00 , C07H17/00 , C07H5/04 , C07H5/06 , C07G3/00 , C07G11/00 , C08B37/00 , C13K5/00 , C13K7/00
摘要： Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.
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公开(公告)号：US07700577B2
公开(公告)日：2010-04-20
申请号：US10531303
申请日：2003-10-16
申请人： Wim Meutermans , Giang Le Thanh , Giovani Abbenante , Gerald Tometzki , George Adamson , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam
发明人： Wim Meutermans , Giang Le Thanh , Giovani Abbenante , Gerald Tometzki , George Adamson , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam
IPC分类号： A61K31/715 , C07H1/00 , A01N25/34
CPC分类号： A61K31/7016 , Y02A50/473
摘要： A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,
摘要翻译： 通过使细菌与至少一种通式I的二糖化合物接触来抑制细菌生长的方法，
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公开(公告)号：US20060142217A1
公开(公告)日：2006-06-29
申请号：US10531303
申请日：2003-10-16
申请人： Wim Meutermans , Giang Le Thanh , Giovani Abbenante , Gerald Tometzki , George Adamson , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam
发明人： Wim Meutermans , Giang Le Thanh , Giovani Abbenante , Gerald Tometzki , George Adamson , Bernd Becker , Matthias Grathwohl , Premraj Rajaratnam
IPC分类号： A61K31/7012
CPC分类号： A61K31/7016 , Y02A50/473
摘要： A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,
摘要翻译： 通过使细菌与至少一种通式I的二糖化合物接触来抑制细菌生长的方法，
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