公开(公告)号：US20240270712A1

公开(公告)日：2024-08-15

申请号：US18566534

申请日：2022-06-02

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Ryosuke TANAKA ,  Hirokazu FUJIHARA ,  Shunsuke FUCHI ,  Kosuke FUKATSU

IPC: C07D401/04 ,  A61K9/14 ,  A61K9/16 ,  A61P33/00

CPC classification number: C07D401/04 ,  A61K9/143 ,  A61K9/145 ,  A61K9/1623 ,  A61P33/00

Abstract: An object of the present application is to provide a canine filariasis control agent for an animal, which is administered to a subject animal to exert an excellent effect and a method of using a canine filariasis control agent for a subject animal using the same. The present invention provides a benzimidazole compound represented by general formula (1):




wherein R represents a hydrogen atom, an alkyl group, or the like; Y1, Y2, Y3, Z1, and Z4 represent a hydrogen atom or the like; Z2 and Z3 represent a hydrogen atom, a halogen atom, or the like; R1 represents a haloalkyl group or the like; and X represents an oxygen atom or the like, or a salt thereof. The present invention also provides a canine filariasis control agent for an animal, containing the same as an active ingredient, a method of using the same, and the like.

公开(公告)号：US20240261266A1

公开(公告)日：2024-08-08

申请号：US18566227

申请日：2022-06-02

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Kosuke FUKATSU ,  Ryosuke TANAKA ,  Hirokazu FUJIHARA

IPC: A61K31/4184 ,  A61P33/14 ,  C07D405/04

CPC classification number: A61K31/4184 ,  A61P33/14 ,  C07D405/04

Abstract: An object of the present invention is to develop and provide a new drug that has an activity against canine filariasis having concerns about the possibility of developing resistance to addictive agents due to long-term use of canine filariasis control agents and that can be used to treat infections caused by canine filariasis. The present invention provides a benzimidazole compound represented by general formula (1):




wherein R, Y1, Y2, Y3, and Y4 represent a hydrogen atom or the like, and X represents an alkynyl group or the like, or a salt thereof. The present invention also provides a canine filariasis control agent for an animal, containing the same as an active ingredient, and a method of using the same.

公开(公告)号：US20230121730A1

公开(公告)日：2023-04-20

申请号：US17252455

申请日：2019-08-06

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Naoya FUJITA ,  Masao YAMASHITA ,  Ryusuke KISHIGAMI ,  Hiroko SATOH

IPC: A01N43/82 ,  C07D271/06 ,  C07D417/12 ,  C07D413/12 ,  C07D413/10 ,  C07D495/04 ,  C07D487/04 ,  C07D417/10 ,  C07D471/04 ,  A01N43/90 ,  A01P3/00 ,  A01N25/04 ,  A01N25/14

Abstract: In production of crops of agriculture and horticulture or the like, damage caused by diseases is still large, and, due to factors such as occurrence of resistant diseases to existing drugs, development of new agrohorticultural fungicides is desired.
The present invention provides an agrohorticultural fungicide and a method of use thereof of, an active ingredient thereof being a compound represented by the general formula (I) or salts thereof: {wherein X1, X2, X3 and X4 denote a hydrogen atom or the like, A, B, Y, denote a single bond or carbonyl group or the like, Q denotes a (C1-C6)alkyl group or hetero ring or the like, R5 and R6 denote a hydrogen atom or (C1-C6)alkyl group or the like.}.

公开(公告)号：US20230056277A1

公开(公告)日：2023-02-23

申请号：US17780853

申请日：2020-11-27

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Hirokazu FUJIHARA ,  Kazuki FUJII ,  Shunsuke FUCHI ,  Ryosuke TANAKA ,  Kenta AKIMOTO

IPC: A01N43/52 ,  C07D403/04 ,  A01P7/02 ,  A01P7/04

Abstract: An object of the present invention is to develop and provide a novel agricultural and horticultural insecticidal and acaricidal agent due to the emergence of resistant pests against existing drugs and the like in crop production in the fields of agriculture, horticulture and the like, where damages caused by pests and the like have been still serious.
The present invention provides a benzimidazole compound represented by the general formula (1) wherein R is an alkyl group or the like, Y1, Y2, Y3, and Y4 are a hydrogen atom or the like, Q is a 5-membered heterocyclic group optionally having a substituent such as a substituted imidazole bound at a nitrogen atom and a substituted pyrazole bound at a nitrogen atom, or a salt thereof, an agricultural and horticultural insecticidal and acaricidal agent having the compound or a salt thereof as an active ingredient, and a method for using the same.

公开(公告)号：US20220242869A1

公开(公告)日：2022-08-04

申请号：US17595759

申请日：2020-05-26

Applicant: Nihon Nohyaku Co., Ltd.

Inventor： Yusuke Sano ,  Ikki Yonemura

IPC: C07D487/04 ,  A01N43/90 ,  A01P7/04

Abstract: Objects of the present invention are to develop and provide a compound or a salt thereof, and a novel agricultural or horticultural insecticide containing the compound or the salt thereof, and to provide an agent for eliminating ectoparasites or endoparasites of animals. The objects can be achieved by a compound in which a pyridine ring containing an oxime group is bound to a condensed heterocyclic compound having a bridgehead nitrogen atom represented by the following general formula (1): or a salt thereof, an agricultural or horticultural insecticide containing the compound or the salt thereof as an active ingredient, an animal endoparasite or ectoparasite control agent containing the compound or the salt thereof as an active ingredient, and a method for using the insecticide or the control agent.

公开(公告)号：US11252962B2

公开(公告)日：2022-02-22

申请号：US16648714

申请日：2018-09-20

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Ikki Yonemura ,  Shunpei Fujie ,  Ryosuke Tanaka

IPC: A01N43/52 ,  C07D401/04

Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. The present invention has been made in view of such circumstances, and an object of the present invention is to develop and provide a novel agricultural and horticultural insecticide. The present invention provides a benzimidazole compound represented by the general formula (1): {wherein R1 represents a hydrogen atom or a cyano group, R2 and R3 each represent a hydrogen atom, R4 represents a hydrogen atom or a haloalkoxy group, R5 represents a haloalkoxy group, a haloalkylthio group, a haloalkylsulfinyl group, or a haloalkylsulfonyl group, and m represents 0 or 2}, or a salt thereof; an agricultural and horticultural insecticide comprising the compound or the salt as an active ingredient; and a method for using the insecticide.

公开(公告)号：US11208410B2

公开(公告)日：2021-12-28

申请号：US16077971

申请日：2017-02-24

Applicant: Nihon Nohyaku Co., Ltd.

Inventor： Chiaki Yamauchi ,  Ikki Yonemura ,  Akiyuki Suwa ,  Shunpei Fujie

IPC: C07D487/04 ,  C07D213/80 ,  C07D237/20 ,  C07D401/12 ,  C07D471/04 ,  A01N43/40 ,  A01N43/58 ,  A01N43/90

Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. To solve the problems, the present invention has been made, and an object of the present invention is to develop and provide a novel agricultural and horticultural insecticide.
The present invention provides a heterocycle-bound condensed heterocyclic compound represented by the general formula (1): {wherein R1 represents an ethyl group, R2 represents a haloalkyl group, A1 represents a N-methyl group, A2 and A3 represent a nitrogen atom, n represents 1, m represents 2, and Q represents an oxadiazole}, or a salt thereof; an agricultural and horticultural insecticide comprising the compound or a salt thereof as an active ingredient; and a method for using the insecticide.

公开(公告)号：US20200214292A1

公开(公告)日：2020-07-09

申请号：US16648714

申请日：2018-09-20

Applicant: NIHON NOHYAKU CO., LTD.

Inventor： Ikki YONEMURA ,  Shunpei FUJIE ,  Ryosuke TANAKA

IPC: A01N43/52 ,  C07D401/04

Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. The present invention has been made in view of such circumstances, and an object of the present invention is to develop and provide a novel agricultural and horticultural insecticide. The present invention provides a benzimidazole compound represented by the general formula (1): {wherein R1 represents a hydrogen atom or a cyano group, R2 and R3 each represent a hydrogen atom, R4 represents a hydrogen atom or a haloalkoxy group, R5 represents a haloalkoxy group, a haloalkylthio group, a haloalkylsulfinyl group, or a haloalkylsulfonyl group, and m represents 0 or 2}, or a salt thereof; an agricultural and horticultural insecticide comprising the compound or the salt as an active ingredient; and a method for using the insecticide.

公开(公告)号：US10702507B2

公开(公告)日：2020-07-07

申请号：US16159882

申请日：2018-10-15

Applicant: THE UNIVERSITY OF TOKYO ,  NIHON NOHYAKU CO., LTD.

Inventor： Kiyoshi Kita ,  Akiyuki Suwa ,  Masatsugu Oda

IPC: A61K31/44 ,  A61K31/166 ,  C07D213/643 ,  C07D213/61 ,  C07D215/227 ,  C07D277/68 ,  C07D231/20 ,  C07D233/66 ,  C07D241/44 ,  C07D239/60 ,  C07D239/34 ,  C07D263/58 ,  C07D241/18 ,  C07C233/66 ,  C07C233/73

Abstract: The present invention is intended to provide a novel parasiticide, antiprotozoal or other endoparasite control agents which are effective for controlling animal endoparasites that have been impossible to control by conventional ones. Provided is an endoparasite control agent comprising, as an active ingredient, a carboxamide derivative represented by the general formula (I): or a salt thereof.

公开(公告)号：US10292395B2

公开(公告)日：2019-05-21

申请号：US15775296

申请日：2016-11-30

Applicant: Nihon Nohyaku Co., Ltd.

Inventor： Ikki Yonemura ,  Yusuke Sano ,  Akiyuki Suwa ,  Shunpei Fujie

IPC: C07D401/04 ,  A01N43/90 ,  A01N43/40 ,  A61K31/437 ,  A61K31/4439 ,  C07D471/04

Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. Under such circumstances, the development of novel agricultural and horticultural insecticides is desired. The present invention provides an agricultural and horticultural insecticide comprising, as an active ingredient, a 3H-pyrrolopyridine compound represented by the general formula (1): (wherein A1, A2, and A3 each represent a nitrogen atom or a CH group, R1 represents an ethyl group, R2 and R4 each represent a hydrogen atom, R3 and R7 each represent a haloalkyl group, R5 and R6 each represent a fluorine atom, and m represents 0 or 2), an N-oxide thereof or a salt thereof; and a method for using the agricultural and horticultural insecticide.