公开(公告)号：US20200156074A1

公开(公告)日：2020-05-21

申请号：US16689530

申请日：2019-11-20

申请人： Nongjian Tao ,  Wenwen Jing

发明人： Nongjian Tao ,  Wenwen Jing

IPC分类号： B01L3/00 ,  G01N1/38 ,  G01N33/543

摘要： A method for detecting biomarkers with shortened test time and maximized precision. A sample from the body fluid is made to flow over a sensor surface coated with a capture antibody to allow binding of a biomarker in the sample to the capture body. An optical method detects and counts the individual binding events along the sensor surface with single molecule resolution, and difference in the binding events along the sensor surface is detected in real time and analyzed to determine the biomarker concentration.

公开(公告)号：US10143401B2

公开(公告)日：2018-12-04

申请号：US13493552

申请日：2012-06-11

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： A61B5/08 ,  A61B5/083 ,  G06Q50/22

摘要： A method for weight and/or fitness management using a metabolic analyzer that measures metabolic data including oxygen and carbon dioxide. The metabolic analyzer includes integrated collection-detection sensors with for high efficiency and collection, high specificity and simultaneous detection of at least two metabolic signatures, including at least oxygen and carbon dioxide, in breath via a porous membrane with high density of sensing binding sites, where the porous membrane includes sensing materials such that the sensing binding sites are specific to the metabolic signatures, and change colors upon interactions with the metabolic signatures. Weight of the subject is measured using a weight measurement device and a recommendation for food intake and/or physical activity is based on at least the readings of the metabolic analyzer and weight of the subject.

公开(公告)号：US09581561B2

公开(公告)日：2017-02-28

申请号：US14160035

申请日：2014-01-21

申请人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A Iglesias

发明人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A Iglesias

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N27/27 ,  G01N21/78 ,  G01N31/22 ,  G01N21/05

CPC分类号： G01N27/27 ,  G01N21/05 ,  G01N21/783 ,  G01N31/223 ,  G01N33/0037 ,  Y02A50/245 ,  Y10T436/173845

摘要： A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

摘要翻译： 一种基于光电化学和光电信号检测的气相检测系统。 传感平台对于检测低ppbV浓度的氮氧化物特别强大。 光化学分析是由于化学反应发生在优化材料中的颜色发展。 电化学分析可以基于电化学传感器的掺杂水平或氧化还原电位变化; 光电化学检测可以基于电化学和光电化学方法的组合。 可以同时检测每个独立信号，提高检测的可靠性。

公开(公告)号：US20130248379A1

公开(公告)日：2013-09-26

申请号：US13893181

申请日：2013-05-13

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： G01N27/27

CPC分类号： G01N27/27 ,  G01N27/3277

摘要： An integrated sensing device is capable of detecting analytes using electrochemical (EC) and electrical (E) signals. The device introduces synergetic new capabilities and enhances the sensitivity and selectivity for real-time detection of an analyte in complex matrices, including the presence of high concentration of interferences in liquids and in gas phases.

摘要翻译： 集成的感测装置能够使用电化学（EC）和电（E）信号来检测分析物。 该设备引入了协同的新功能，并增强了对复杂基质中分析物的实时检测的灵敏度和选择性，包​​括在液体和气相中存在高浓度的干扰。

公开(公告)号：US20130150746A1

公开(公告)日：2013-06-13

申请号：US13493552

申请日：2012-06-11

申请人： Nongjian Tao ,  Erica Forzani

发明人： Nongjian Tao ,  Erica Forzani

IPC分类号： A61B5/083

CPC分类号： A61B5/0833 ,  A61B5/08 ,  A61B5/083 ,  A61B5/0836 ,  G06F19/00 ,  G06Q50/22 ,  Y02P90/84 ,  Y02P90/845

摘要： A method for weight and/or fitness management using a metabolic analyzer that measures metabolic data including oxygen and carbon dioxide. The metabolic analyzer includes integrated collection-detection sensors with for high efficiency and collection, high specificity and simultaneous detection of at least two metabolic signatures, including at least oxygen and carbon dioxide, in breath via a porous membrane with high density of sensing binding sites, where the porous membrane includes sensing materials such that the sensing binding sites are specific to the metabolic signatures, and change colors upon interactions with the metabolic signatures. Weight of the subject is measured using a weight measurement device and a recommendation for food intake and/or physical activity is based on at least the readings of the metabolic analyzer and weight of the subject.

摘要翻译： 使用代谢分析仪测量包括氧气和二氧化碳在内的代谢数据的体重和/或健康管理方法。 代谢分析仪包括集成采集检测传感器，通过具有高密度感测结合位点的多孔膜，具有高效率和收集性，高特异度和同时检测至少两种代谢特征（包括至少氧气和二氧化碳） 其中多孔膜包括感测材料，使得感测结合位点对于代谢特征是特异性的，并且在与代谢特征相互作用时改变颜色。 使用体重测量装置测量受试者的体重，并且关于食物摄取和/或身体活动的建议至少基于代谢分析仪的读数和受试者的体重。

公开(公告)号：US20120118045A1

公开(公告)日：2012-05-17

申请号：US13322898

申请日：2010-06-02

申请人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A. Iglesias

发明人： Nongjian Tao ,  Erica Forzani ,  Rodrigo A. Iglesias

IPC分类号： G01N7/00

CPC分类号： G01N27/27 ,  G01N21/05 ,  G01N21/783 ,  G01N31/223 ,  G01N33/0037 ,  Y02A50/245 ,  Y10T436/173845

摘要： A gas-phase detection system based on detecting optochemical and optoelectrochemical signals. The sensing platform is particularly powerful for detection of nitrogen oxides at low ppbV concentrations. The optochemical analysis is based on the color development due to a chemical reaction taking place in an optimized material. The electrochemical analysis can be based on the doping level or redox potential changes of an electrochemical sensor; and optoelectrochemical detection can be based on a combination of the electrochemical and optoelectrochemical methodologies. Each independent signal can be simultaneously detected, increasing the reliability of detection.

摘要翻译： 一种基于光电化学和光电信号检测的气相检测系统。 传感平台对于检测低ppbV浓度的氮氧化物特别强大。 光化学分析是由于化学反应发生在优化材料中的颜色发展。 电化学分析可以基于电化学传感器的掺杂水平或氧化还原电位变化; 光电化学检测可以基于电化学和光电化学方法的组合。 可以同时检测每个独立信号，提高检测的可靠性。

公开(公告)号：US10740650B2

公开(公告)日：2020-08-11

申请号：US16059904

申请日：2018-08-09

申请人： Nongjian Tao ,  Yuting Yang

发明人： Nongjian Tao ,  Yuting Yang

IPC分类号： G06K9/62 ,  G06T7/20 ,  G06K9/00

摘要： Systems and methods for tracking and analysis physical activity is disclosed. In some aspects, a provided method includes receiving a time sequence of images captured while with an individual is performing the physical activity, and generating, using the time sequence of images, at least one map indicating a movement of the individual. The method also includes identifying at least one body portion using the at least one map, and computing at least one index associated with the identified body portions to characterize the physical activity of the individual. The method further includes generating a report using the at least one index.

公开(公告)号：US10539530B2

公开(公告)日：2020-01-21

申请号：US15709032

申请日：2017-09-19

申请人： Nongjian Tao

发明人： Nongjian Tao

IPC分类号： G01N27/60 ,  B82Y35/00 ,  G01B11/00 ,  G01N15/06 ,  G01N33/00

摘要： A system for analyzing a content of a sample material is presented. The system includes a fiber sensitized to a first substance, and at least one electrode configured to expose the fiber to an electric field. The system includes an optical sensor configured to detect a displacement of the fiber when the fiber is exposed to the electric field, and a processor configured to use the displacement of the fiber to characterize a content of the sample material.

公开(公告)号：US20190325257A1

公开(公告)日：2019-10-24

申请号：US16059904

申请日：2018-08-09

申请人： Nongjian Tao ,  Yuting Yang

发明人： Nongjian Tao ,  Yuting Yang

IPC分类号： G06K9/62 ,  G06T7/20

摘要： Systems and methods for tracking and analysis physical activity is disclosed. In some aspects, a provided method includes receiving a time sequence of images captured while with an individual is performing the physical activity, and generating, using the time sequence of images, at least one map indicating a movement of the individual. The method also includes identifying at least one body portion using the at least one map, and computing at least one index associated with the identified body portions to characterize the physical activity of the individual. The method further includes generating a report using the at least one index.

公开(公告)号：US20190170748A1

公开(公告)日：2019-06-06

申请号：US16270312

申请日：2019-02-07

申请人： Nongjian Tao ,  Karan Syal

发明人： Nongjian Tao ,  Karan Syal

IPC分类号： G01N33/569 ,  G01N33/543

CPC分类号： G01N33/56916 ,  G01N33/54373 ,  G01N33/56911

摘要： A rapid antibiotic susceptibility test (AST) based on the detection and quantification of the movement of single bacterial cells with a plasmonic imaging and tracking (PIT) technology. The PIT-based AST detects changes in the metabolic activity of the bacterial cells long before cell replication, and allows rapid AST for both cultivable and non-cultivable strains. PIT tracks 3D movement with sub-nanometer resolution and millisecond temporal resolution. PIT also allows simultaneous measurement of the binding kinetic constants of antibiotics and bacterial metabolic state after the introduction of antibiotics.