公开(公告)号：US07815677B2

公开(公告)日：2010-10-19

申请号：US11775043

申请日：2007-07-09

申请人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

发明人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2250/006 ,  Y10T29/49412

摘要： A reinforcement device for a biological valve includes an arrangement of supports configured to establish a double-trigone geometry in the valve and coupled to a base upon which the valve may be mounted. A plurality of commissural supports establish the geometry of a commissural trigone, and a plurality of intercommissural supports establish the geometry of an intercommissural trigone. A method for reinforcing a biological valve includes using commissural supports in conjunction with intercommissural supports, both sets of supports coupled to a base upon which the valve is mounted.

摘要翻译： 用于生物瓣膜的加强装置包括支撑件的布置，其构造成在阀中建立双三角形几何形状并且联接到可以安装阀的基座。 多个连合支架建立了连合三角体的几何形状，并且多个连合间支架建立了并发性三角体的几何形状。 一种用于加强生物瓣膜的方法包括使用连合支撑结合连合间支撑，两组支撑件联接到安装有阀的底座上。

公开(公告)号：US20110022167A1

公开(公告)日：2011-01-27

申请号：US12896601

申请日：2010-10-01

申请人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

发明人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

IPC分类号： A61F2/24 ,  B21D51/16

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2250/006 ,  Y10T29/49412

摘要： A reinforcement device for a biological valve includes an arrangement of supports configured to establish a double-trigone geometry in the valve and coupled to a base upon which the valve may be mounted. A plurality of commissural supports establish the geometry of a commissural trigone, and a plurality of intercommissural supports establish the geometry of an intercommissural trigone. A method for reinforcing a biological valve includes using commissural supports in conjunction with intercommissural supports, both sets of supports coupled to a base upon which the valve is mounted.

摘要翻译： 用于生物瓣膜的加强装置包括支撑件的布置，其构造成在阀中建立双三角形几何形状并且联接到可以安装阀的基座。 多个连合支架建立了连合三角体的几何形状，并且多个连合间支架建立了并发性三角体的几何形状。 一种用于加强生物瓣膜的方法包括使用连合支撑结合连合间支撑，两组支撑件联接到安装有阀的底座上。

公开(公告)号：US20090018649A1

公开(公告)日：2009-01-15

申请号：US11775043

申请日：2007-07-09

申请人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

发明人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2250/006 ,  Y10T29/49412

摘要： A reinforcement device for a biological valve includes an arrangement of supports configured to establish a double-trigone geometry in the valve and coupled to a base upon which the valve may be mounted. A plurality of commissural supports establish the geometry of a commissural trigone, and a plurality of intercommissural supports establish the geometry of an intercommissural trigone. A method for reinforcing a biological valve includes using commissural supports in conjunction with intercommissural supports, both sets of supports coupled to a base upon which the valve is mounted.

摘要翻译： 用于生物瓣膜的加强装置包括支撑件的布置，其构造成在阀中建立双三角形几何形状并且联接到可以安装阀的基座。 多个连合支架建立了连合三角体的几何形状，并且多个连合间支架建立了并发性三角体的几何形状。 一种用于加强生物瓣膜的方法包括使用连合支撑结合连合间支撑，两组支撑件联接到安装有阀的底座上。

公开(公告)号：US5595571A

公开(公告)日：1997-01-21

申请号：US229452

申请日：1994-04-18

申请人： Norman Jaffe ,  Warren B. Hancock

发明人： Norman Jaffe ,  Warren B. Hancock

IPC分类号： A61L27/36 ,  A61L17/00 ,  A61F2/02 ,  D01C3/00

CPC分类号： A61L27/3683 ,  A61L27/3604 ,  A61L27/3645 ,  A61L27/3687 ,  A61L27/3691 ,  Y10S623/901 ,  Y10S623/915

摘要： Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH in the range from about 5.0 to 8.0 and a temperature in the range from about 12.degree. C. to 30.degree. C. for a sufficient period of time to render at least one region of the biological material substantially acellular while substantially preserving the structural integrity and non-cellular structural components of the biological material. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.

摘要翻译： 公开了一种受控的自溶方法，用于通过在生物材料的任何固定之前将生物材料暴露于至少一种pH在约5.0至8.0范围内的温度和约12 在30℃保持足够的时间以使生物材料的至少一个区域基本上不含细胞，同时基本上保留生物材料的结构完整性和非细胞结构组分。 还公开了一种使用已经通过受控自溶进行治疗的生物材料制备生物假体心脏瓣膜的方法，以及一种使用生物假体心脏瓣膜来治疗具有缺陷性心脏瓣膜的哺乳动物的方法，所述生物假体心脏瓣膜部分地通过受控的自溶制备。

公开(公告)号：US20170128212A1

公开(公告)日：2017-05-11

申请号：US15414794

申请日：2017-01-25

申请人： Sean Chambers ,  Ram Paul ,  Norman Jaffe

发明人： Sean Chambers ,  Ram Paul ,  Norman Jaffe

IPC分类号： A61F2/24

CPC分类号： A61F2/2475 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2240/001 ,  A61F2250/0098

摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.

公开(公告)号：US08393201B2

公开(公告)日：2013-03-12

申请号：US12886799

申请日：2010-09-21

申请人： Norman Jaffe ,  Jose Crisologo

发明人： Norman Jaffe ,  Jose Crisologo

IPC分类号： G01M15/00

CPC分类号： G01M15/042 ,  G01M15/02

摘要： A method of sensing vehicle engine ignition status is disclosed wherein samples of only the electrical system voltage levels are used. Sampling voltages that drop sufficiently (in magnitude and quantity over a period of time) will signify an “engine off” state.

摘要翻译： 公开了一种感测车辆发动机点火状态的方法，其中仅使用电气系统电压电平的采样。 一个足够下降的采样电压（一段时间内的幅度和数量）将表示发动机关闭状态。

公开(公告)号：US20120067113A1

公开(公告)日：2012-03-22

申请号：US12886799

申请日：2010-09-21

申请人： Norman Jaffe ,  Jose Crisologo

发明人： Norman Jaffe ,  Jose Crisologo

IPC分类号： G01M15/00

CPC分类号： G01M15/042 ,  G01M15/02

摘要： A method of sensing vehicle engine ignition status is disclosed wherein samples of only the electrical system voltage levels are used. Sampling voltages that drop sufficiently (in magnitude and quantity over a period of time) will signify an “engine off” state.

摘要翻译： 公开了一种感测车辆发动机点火状态的方法，其中仅使用电气系统电压电平的采样。 足够下降的采样电压（在一段时间内的幅度和数量）将表示“发动机关闭”状态。

公开(公告)号：US07127477B2

公开(公告)日：2006-10-24

申请号：US10290085

申请日：2002-11-06

申请人： Chris Duncombe ,  Norman Jaffe ,  Nicholas M. Swain

发明人： Chris Duncombe ,  Norman Jaffe ,  Nicholas M. Swain

IPC分类号： G06F12/00 ,  G06F15/16

CPC分类号： G06F21/606 ,  G06F11/1464 ,  Y10S707/99954

摘要： A method and system for the simple, fast, and effective maintenance of consistent data files across a multiplicity of computer systems, which functionality is useful in collaborative work, effective backup, and disaster recovery. Consistency is maintained using secure file storage remote from any number of clients the files on which are automatically synchronized consuming minimal network bandwidth. Automated bi-directional “one-click” synchronization is implemented via a method that is neutral with respect to platform, operating system, firewall, and network configuration. The software product based on the invented method has the substantial advantage of installation, setup, and operation all without intervention by system administrators.

公开(公告)号：US5843181A

公开(公告)日：1998-12-01

申请号：US786395

申请日：1997-01-17

申请人： Norman Jaffe ,  Warren D. Hancock

发明人： Norman Jaffe ,  Warren D. Hancock

IPC分类号： A61L27/36 ,  A61F2/24 ,  B01C3/00

CPC分类号： A61L27/3683 ,  A61L27/3604 ,  A61L27/3645 ,  A61L27/3687 ,  A61L27/3691 ,  Y10S623/901 ,  Y10S623/915

摘要： Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH in the range from about 5.0 to 8.0 and a temperature in the range from about 12.degree. C. to 30.degree. C. for a sufficient period of time to render at least one region of the biological material substantially acellular while substantially preserving the structural integrity and non-cellular structural components of the biological material. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.

摘要翻译： 公开了一种受控的自溶方法，用于通过在生物材料的任何固定之前将生物材料暴露于至少一种pH在约5.0至8.0范围内的温度和约12 在30℃保持足够的时间以使生物材料的至少一个区域基本上不含细胞，同时基本上保留生物材料的结构完整性和非细胞结构组分。 还公开了一种使用已经通过受控自溶进行治疗的生物材料制备生物假体心脏瓣膜的方法，以及一种使用生物假体心脏瓣膜来治疗具有缺陷性心脏瓣膜的哺乳动物的方法，所述生物假体心脏瓣膜部分地通过受控的自溶制备。

公开(公告)号：US5720777A

公开(公告)日：1998-02-24

申请号：US442017

申请日：1995-05-16

申请人： Norman Jaffe ,  Warren D. Hancock

发明人： Norman Jaffe ,  Warren D. Hancock

IPC分类号： A61L27/36 ,  A61F2/24

CPC分类号： A61L27/3683 ,  A61L27/3604 ,  A61L27/3645 ,  A61L27/3687 ,  A61L27/3691 ,  Y10S623/901 ,  Y10S623/915

摘要： Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH in the range from about 5.0 to 8.0 and a temperature in the range from about 12.degree. C. to 30.degree. C. for a sufficient period of time to render at least one region of the biological material substantially acellular while substantially preserving the structural integrity and non-cellular structural components of the biological material. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.