公开(公告)号：US07127477B2

公开(公告)日：2006-10-24

申请号：US10290085

申请日：2002-11-06

申请人： Chris Duncombe ,  Norman Jaffe ,  Nicholas M. Swain

发明人： Chris Duncombe ,  Norman Jaffe ,  Nicholas M. Swain

IPC分类号： G06F12/00 ,  G06F15/16

CPC分类号： G06F21/606 ,  G06F11/1464 ,  Y10S707/99954

摘要： A method and system for the simple, fast, and effective maintenance of consistent data files across a multiplicity of computer systems, which functionality is useful in collaborative work, effective backup, and disaster recovery. Consistency is maintained using secure file storage remote from any number of clients the files on which are automatically synchronized consuming minimal network bandwidth. Automated bi-directional “one-click” synchronization is implemented via a method that is neutral with respect to platform, operating system, firewall, and network configuration. The software product based on the invented method has the substantial advantage of installation, setup, and operation all without intervention by system administrators.

公开(公告)号：US07815677B2

公开(公告)日：2010-10-19

申请号：US11775043

申请日：2007-07-09

申请人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

发明人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2250/006 ,  Y10T29/49412

摘要： A reinforcement device for a biological valve includes an arrangement of supports configured to establish a double-trigone geometry in the valve and coupled to a base upon which the valve may be mounted. A plurality of commissural supports establish the geometry of a commissural trigone, and a plurality of intercommissural supports establish the geometry of an intercommissural trigone. A method for reinforcing a biological valve includes using commissural supports in conjunction with intercommissural supports, both sets of supports coupled to a base upon which the valve is mounted.

摘要翻译： 用于生物瓣膜的加强装置包括支撑件的布置，其构造成在阀中建立双三角形几何形状并且联接到可以安装阀的基座。 多个连合支架建立了连合三角体的几何形状，并且多个连合间支架建立了并发性三角体的几何形状。 一种用于加强生物瓣膜的方法包括使用连合支撑结合连合间支撑，两组支撑件联接到安装有阀的底座上。

公开(公告)号：US20090105813A1

公开(公告)日：2009-04-23

申请号：US12252918

申请日：2008-10-16

申请人： Sean Chambers ,  Ram Paul ,  Norman Jaffe

发明人： Sean Chambers ,  Ram Paul ,  Norman Jaffe

IPC分类号： A61F2/24

CPC分类号： A61F2/2475 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2240/001 ,  A61F2250/0098

摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.

摘要翻译： 描述了阀装置，制造阀装置的方法以及治疗各种静脉相关病症，病症和/或疾病的方法。 在一个实施例中，阀装置包括可扩展支撑框架和附接到支撑框架的生物假肢瓣膜。 生物假肢瓣膜包括从多叶瓣异种瓣膜收获的小叶和邻接的壁部分。 邻接的壁部分包括附件区域，其中小叶附着到血管壁，并且在一些实施例中包括叶片和血管壁之间的附着的天然边缘。

公开(公告)号：US20110022167A1

公开(公告)日：2011-01-27

申请号：US12896601

申请日：2010-10-01

申请人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

发明人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

IPC分类号： A61F2/24 ,  B21D51/16

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2250/006 ,  Y10T29/49412

摘要： A reinforcement device for a biological valve includes an arrangement of supports configured to establish a double-trigone geometry in the valve and coupled to a base upon which the valve may be mounted. A plurality of commissural supports establish the geometry of a commissural trigone, and a plurality of intercommissural supports establish the geometry of an intercommissural trigone. A method for reinforcing a biological valve includes using commissural supports in conjunction with intercommissural supports, both sets of supports coupled to a base upon which the valve is mounted.

摘要翻译： 用于生物瓣膜的加强装置包括支撑件的布置，其构造成在阀中建立双三角形几何形状并且联接到可以安装阀的基座。 多个连合支架建立了连合三角体的几何形状，并且多个连合间支架建立了并发性三角体的几何形状。 一种用于加强生物瓣膜的方法包括使用连合支撑结合连合间支撑，两组支撑件联接到安装有阀的底座上。

公开(公告)号：US20090018649A1

公开(公告)日：2009-01-15

申请号：US11775043

申请日：2007-07-09

申请人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

发明人： Norman Jaffe ,  Afksendiyos Kalangos ,  Yuri Zhivilo

IPC分类号： A61F2/24

CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2220/0033 ,  A61F2230/0013 ,  A61F2250/006 ,  Y10T29/49412

摘要： A reinforcement device for a biological valve includes an arrangement of supports configured to establish a double-trigone geometry in the valve and coupled to a base upon which the valve may be mounted. A plurality of commissural supports establish the geometry of a commissural trigone, and a plurality of intercommissural supports establish the geometry of an intercommissural trigone. A method for reinforcing a biological valve includes using commissural supports in conjunction with intercommissural supports, both sets of supports coupled to a base upon which the valve is mounted.

摘要翻译： 用于生物瓣膜的加强装置包括支撑件的布置，其构造成在阀中建立双三角形几何形状并且联接到可以安装阀的基座。 多个连合支架建立了连合三角体的几何形状，并且多个连合间支架建立了并发性三角体的几何形状。 一种用于加强生物瓣膜的方法包括使用连合支撑结合连合间支撑，两组支撑件联接到安装有阀的底座上。

公开(公告)号：US5595571A

公开(公告)日：1997-01-21

申请号：US229452

申请日：1994-04-18

申请人： Norman Jaffe ,  Warren B. Hancock

发明人： Norman Jaffe ,  Warren B. Hancock

IPC分类号： A61L27/36 ,  A61L17/00 ,  A61F2/02 ,  D01C3/00

CPC分类号： A61L27/3683 ,  A61L27/3604 ,  A61L27/3645 ,  A61L27/3687 ,  A61L27/3691 ,  Y10S623/901 ,  Y10S623/915

摘要： Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH in the range from about 5.0 to 8.0 and a temperature in the range from about 12.degree. C. to 30.degree. C. for a sufficient period of time to render at least one region of the biological material substantially acellular while substantially preserving the structural integrity and non-cellular structural components of the biological material. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.

摘要翻译： 公开了一种受控的自溶方法，用于通过在生物材料的任何固定之前将生物材料暴露于至少一种pH在约5.0至8.0范围内的温度和约12 在30℃保持足够的时间以使生物材料的至少一个区域基本上不含细胞，同时基本上保留生物材料的结构完整性和非细胞结构组分。 还公开了一种使用已经通过受控自溶进行治疗的生物材料制备生物假体心脏瓣膜的方法，以及一种使用生物假体心脏瓣膜来治疗具有缺陷性心脏瓣膜的哺乳动物的方法，所述生物假体心脏瓣膜部分地通过受控的自溶制备。

公开(公告)号：US10722365B2

公开(公告)日：2020-07-28

申请号：US15414794

申请日：2017-01-25

申请人： Sean Chambers ,  Ram Paul ,  Norman Jaffe

发明人： Sean Chambers ,  Ram Paul ,  Norman Jaffe

IPC分类号： A61F2/24

摘要： Valve devices, methods of making valve devices, and methods of treating various venous-related conditions, disorders and/or diseases are described. In one embodiment, a valve device includes an expandable support frame and a bioprosthetic valve attached to the support frame. The bioprosthetic valve comprises a leaflet and a contiguous wall portion harvested from a multi-leaflet xenogeneic valve. The contiguous wall portion includes the attachment region where the leaflets attaches to the vessel wall and, in some embodiments, includes the natural margins of attachment between the leaflet and vessel wall.

公开(公告)号：US20100234939A1

公开(公告)日：2010-09-16

申请号：US12789176

申请日：2010-05-27

申请人： Norman Jaffe

发明人： Norman Jaffe

IPC分类号： A61F2/06

CPC分类号： A61L27/507 ,  A61F2/2412 ,  A61F2/2475 ,  A61L27/3625

摘要： A bioprosthetic valve for repairing a deep venous insufficiency in a subject includes a single leaflet from a xenogeneic heart valve attached at natural margins of attachment to a patch of valve wall tissue. The patch may extend axially above and below the leaflet and circumferentially on either side of the leaflet to provide a region for attaching the patch to a fenestration in a host vein. A bioprosthetic valve may be manufactured by excising a portion of a xenogeneic heart valve including a single leaflet and contiguous wall tissue, and may further comprise shaving off excess leaflet tissue from adjacent leaflets. A method of replacing a malfunctioning venous valve in a subject includes providing a bioprosthetic valve as described above and inserting it to the host vein.

摘要翻译： 用于修复受试者深静脉功能不全的生物假体瓣包括来自异位心脏瓣膜的单个叶片，其附接到瓣膜组织贴片的自然边缘处。 补片可以在瓣叶的轴向上方和下方延伸，并沿圆周方向延伸在小叶的两侧，以提供用于将贴片附接到宿主静脉中的开窗的区域。 可以通过切除包括单个叶片和邻接的壁组织的异种心脏瓣膜的一部分来制造生物假体瓣膜，并且还可以包括从相邻小叶剥落多余的小叶组织。 更换受试者中的故障静脉瓣的方法包括提供如上所述的生物假体瓣膜并将其插入宿主静脉。

公开(公告)号：US20090105810A1

公开(公告)日：2009-04-23

申请号：US12252253

申请日：2008-10-15

申请人： Norman Jaffe

发明人： Norman Jaffe

IPC分类号： A61F2/06

CPC分类号： A61L27/507 ,  A61F2/2412 ,  A61F2/2475 ,  A61L27/3625

摘要： A bioprosthetic valve for repairing a deep venous insufficiency in a subject includes a single leaflet from a xenogeneic heart valve attached at natural margins of attachment to a patch of valve wall tissue. The patch may extend axially above and below the leaflet and circumferentially on either side of the leaflet to provide a region for attaching the patch to a fenestration in a host vein. A bioprosthetic valve may be manufactured by excising a portion of a xenogeneic heart valve including a single leaflet and contiguous wall tissue, and may further comprise shaving off excess leaflet tissue from adjacent leaflets. A method of replacing a malfunctioning venous valve in a subject includes providing a bioprosthetic valve as described above and inserting it to the host vein.

摘要翻译： 用于修复受试者深静脉功能不全的生物假体瓣包括来自异位心脏瓣膜的单个叶片，其附接到瓣膜组织贴片的自然边缘处。 补片可以在瓣叶的轴向上方和下方延伸，并沿圆周方向延伸在小叶的两侧，以提供用于将贴片附接到宿主静脉中的开窗的区域。 可以通过切除包括单个叶片和邻接的壁组织的异种心脏瓣膜的一部分来制造生物假体瓣膜，并且还可以包括从相邻小叶剥落多余的小叶组织。 更换受试者中的故障静脉瓣的方法包括提供如上所述的生物假体瓣膜并将其插入宿主静脉。

公开(公告)号：US5843180A

公开(公告)日：1998-12-01

申请号：US783934

申请日：1997-01-17

申请人： Norman Jaffe ,  Warren D. Hancock

发明人： Norman Jaffe ,  Warren D. Hancock

IPC分类号： A61L27/36 ,  A61F2/24

CPC分类号： A61L27/3683 ,  A61L27/3604 ,  A61L27/3645 ,  A61L27/3687 ,  A61L27/3691 ,  Y10S623/901 ,  Y10S623/915

摘要： Disclosed is a controlled autolysis method for making biological tissue substantially acellular by exposing the biological material, prior to any fixation thereof, to at least one buffered solution having a pH in the range from about 5.0 to 8.0 and a temperature in the range from about 12.degree. C. to 30.degree. C. for a sufficient period of time to render at least one region of the biological material substantially acellular while substantially preserving the structural integrity and non-cellular structural components of the biological material. Also disclosed is a method of making a bioprosthetic heart valve using biological material that has been treated by controlled autolysis and a method of treating a mammal having a defective heart valve using a bioprosthetic heart valve made, in part, by controlled autolysis.

摘要翻译： 公开了一种受控的自溶方法，用于通过在生物材料的任何固定之前将生物材料暴露于至少一种pH在约5.0至8.0范围内的温度和约12 在30℃保持足够的时间以使生物材料的至少一个区域基本上不含细胞，同时基本上保留生物材料的结构完整性和非细胞结构组分。 还公开了一种使用已经通过受控自溶进行治疗的生物材料制备生物假体心脏瓣膜的方法，以及一种使用生物假体心脏瓣膜来治疗具有缺陷性心脏瓣膜的哺乳动物的方法，所述生物假体心脏瓣膜部分地通过受控的自溶制备。