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1.发明授权[(5,6,9a-substituted-3-oxo-1,2,9,9a-tet rahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid esters and their analogs, the parent acids and their salts 失效[（5,6,9a-取代-3-氧代-1,2,9,9a-四氢-3H-芴-7-基）氧]链烷酸和环烷酸酯及其类似物，母体酸及其盐
公开(公告)号：US4356313A
公开(公告)日：1982-10-26
申请号：US235376
申请日：1981-02-19
IPC分类号： C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07C69/734 , C07D211/42 , C07D211/46 , C07D213/30 , C07D295/088 , C07D307/42 , C07D317/24 , C07C69/94
CPC分类号： C07D213/30 , C07C243/00 , C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07D211/42 , C07D211/46 , C07D295/088 , C07D307/42 , C07D317/24 , C07C2103/18
摘要： The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
摘要翻译： 本发明涉及新的[（5,6,9a-取代-3-氧代-1,2,9,9a-四氢-3H-芴-7-基）氧基]烷基和环烷酸及其类似物，酯， 盐和衍生物。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防由于事故，缺血性卒中和脑积水引起的脑和脊髓损伤; 还公开了用于这些用途的组合物。
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2.发明授权[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkano ic and cycloalkanoic acids, their analogs, esters, salts, and derivatives 失效[（5,6,9-取代的-3-氧代-1,2,9,9a-四氢-3H-芴-7-基）氧基]链烷酸和环烷酸，它们的类似物，酯，盐和衍生物
公开(公告)号：US4337354A
公开(公告)日：1982-06-29
申请号：US236079
申请日：1981-02-19
IPC分类号： C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07C69/95 , C07D211/42 , C07D211/46 , C07D213/30 , C07D295/088 , C07D307/42 , C07D317/24 , C07C69/94
CPC分类号： C07D213/30 , C07C243/00 , C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07D211/42 , C07D211/46 , C07D295/088 , C07D307/42 , C07D317/24 , C07C2103/18 , Y10S514/87
摘要： The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acid and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
摘要翻译： 本发明涉及新的[（5,6,9a-取代-3-氧代-1,2,9,9a-四氢-3H-芴-7-基）氧基]烷基和环烷酸及其类似物，酯， 盐和衍生物。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防由于事故，缺血性卒中和脑积水引起的脑和脊髓损伤; 还公开了用于这些用途的组合物。
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公开(公告)号：US4317922A
公开(公告)日：1982-03-02
申请号：US236081
申请日：1981-02-19
IPC分类号： C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/66 , C07C59/90 , C07C62/38 , C07C69/712 , C07D211/42 , C07D211/46 , C07D213/30 , C07D295/088 , C07D307/42 , C07D317/24 , C07C69/94
CPC分类号： C07D213/30 , C07C243/00 , C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07D211/42 , C07D211/46 , C07D295/088 , C07D307/42 , C07D317/24 , C07C2103/18 , Y10S514/87
摘要： The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
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4.发明授权[(5,6,9a-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alka noic and cycloalkanoic acids and their analogs, esters, salts and derivatives 失效[（5,6,9-取代的-3-氧代-1,2,9,9a-四氢-3H-芴-7-基）氧基]链烷酸和环烷酸及其类似物，酯，盐和衍生物
公开(公告)号：US4316043A
公开(公告)日：1982-02-16
申请号：US218335
申请日：1980-12-19
IPC分类号： C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/68 , C07C45/71 , C07C45/73 , C07C49/755 , C07C59/90 , C07C69/94
CPC分类号： C07C59/90 , C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/68 , C07C45/71 , C07C45/73 , C07C49/755 , C07C2103/18
摘要： The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)-oxy]alkanoic and cycloalkanoic acids and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
摘要翻译： 本发明涉及新的[（5,6,9a-取代-3-氧-1,2 -1,2,9,9a-四氢-3H-芴-7-基） - 氧基]烷酸和环烷酸及其类似物，酯 ，盐和衍生物。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防由于事故，缺血性卒中和脑积水引起的脑和脊髓损伤; 还公开了用于这些用途的组合物。
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5.发明授权[5,6,9A-Substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoi c and cycloalkanoic acids, their analogs, esters, salts, and derivatives 失效[5,6,9A-取代的-3-氧代-1,2,9,9a-四氢-3H-芴-7-基）氧基]链烷酸和环烷酸，它们的类似物，酯，盐和衍生物
公开(公告)号：US4356314A
公开(公告)日：1982-10-26
申请号：US236076
申请日：1981-02-19
IPC分类号： A61K31/235 , C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07D211/42 , C07D211/46 , C07D213/30 , C07D295/088 , C07D307/42 , C07D317/24 , C07C69/94
CPC分类号： C07D213/30 , C07C243/00 , C07C43/225 , C07C45/28 , C07C45/46 , C07C45/66 , C07C45/67 , C07C45/68 , C07C45/71 , C07C45/73 , C07C59/64 , C07C59/90 , C07C62/38 , C07D211/42 , C07D211/46 , C07D295/088 , C07D307/42 , C07D317/24 , C07C2103/18
摘要： The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoic and cycloalkanoic acids, and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
摘要翻译： 本发明涉及新的[（5,6,9a-取代-3-氧-1,2 -1,2,9,9a-四氢-3H-芴-7-基）氧]烷酸和环烷酸及其类似物酯 ，盐和衍生物。 这些化合物根据具体结构，中间体或优选反应顺序的选择，通过选自多种合成途径的方法合成。 该化合物可用于治疗和预防由于事故，缺血性卒中和脑积水引起的脑和脊髓损伤; 还公开了用于这些用途的组合物。
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