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177 条记录 (耗时 0.028 秒)

    Derivatives of 1,2-benzisoxazoles
    7.
    发明授权
    Derivatives of 1,2-benzisoxazoles 失效
    1,2-苯并异恶唑的衍生物

    公开(公告)号：US4156005A

    公开(公告)日：1979-05-22

    申请号：US917692

    申请日：1978-06-21

    申请人： Gerald E. Stokker ,  Edward J. Cragoe, Jr.

    发明人： Gerald E. Stokker ,  Edward J. Cragoe, Jr.

    IPC分类号： C07C45/56 ,  C07D261/20 ,  A61K31/42

    CPC分类号： C07D261/20 ,  C07C45/565

    摘要： Substituted 1,2-benzisoxazoles of the formula ##STR1## where: R.sup.1 and R.sup.3 =H or lower alkoxy;R.sup.2 =halo or .alpha.-branched lower alkyl;R.sup.4 =halo, halo lower alkyl, or lower alkylthio; provided, where R.sup.1 and R.sup.3 =H,R.sup.2 and R.sup.4 are other than simultaneously Cl or Br, which are active as antiinflammatory, antipyretic and analgesic agents, are derived from cyclodehydrating the corresponding salicylaldoximes with an isocyanate under extremely mild conditions.

    摘要翻译： 取代的1,2-苯并异恶唑，其结构式如下：

    Substituted 2-aminomethylphenyl sulfamates
    8.
    发明授权
    Substituted 2-aminomethylphenyl sulfamates 失效
    取代的2-氨基乙基苯磺酸盐

    公开(公告)号：US4113877A

    公开(公告)日：1978-09-12

    申请号：US833930

    申请日：1977-09-16

    申请人： Robert L. Smith ,  Gerald E. Stokker ,  Edward J. Cragoe, Jr.

    发明人： Robert L. Smith ,  Gerald E. Stokker ,  Edward J. Cragoe, Jr.

    IPC分类号： A61K31/16 ,  A61P7/10 ,  C07C67/00 ,  C07C301/00 ,  C07C303/40 ,  C07C307/02 ,  A61K31/095 ,  C07C141/16

    CPC分类号： C07C307/02

    摘要： Substituted 2-aminomethylphenyl sulfamates and pharmaceutically acceptable acid addition salts wherein the sulfamate group is N-substituted with up to 2 groups and the phenyl nucleus is further substituted by from 2 to 4 nuclear substituents which are useful as diuretics and saluretics are disclosed. The products may be prepared by reacting a N-protected substituted 2-aminomethylphenol with a substituted sulfamoyl chloride to generate an intermediate which is N-deblocked to give the compounds of this invention.

    摘要翻译： 公开了取代的2-氨基甲基苯基氨基磺酸盐和药学上可接受的酸加成盐，其中氨基磺酸酯基团被至多2个基团N-取代，并且苯基基团进一步被2至4个可用作利尿剂和盐析剂的核取代基取代。 产物可以通过使N-保护的取代的2-氨基甲基苯酚与取代的氨磺酰氯反应，以产生N-去闭锁的中间体，得到本发明的化合物。