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公开(公告)号：US10519213B2
公开(公告)日：2019-12-31
申请号：US16517988
申请日：2019-07-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： A61K38/00 , C07K14/635 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52 , A61K9/00
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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公开(公告)号：US10358471B2
公开(公告)日：2019-07-23
申请号：US16249540
申请日：2019-01-16
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： C07K14/00 , C07K14/635 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52 , A61K9/00
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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公开(公告)号：US20190338010A1
公开(公告)日：2019-11-07
申请号：US16517988
申请日：2019-07-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： C07K14/635 , A61K9/00 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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公开(公告)号：US20240312328A1
公开(公告)日：2024-09-19
申请号：US18607250
申请日：2024-03-15
发明人： Richard MILANI , Jonathan WILT , Matthew HERZOG
CPC分类号： G08B21/043 , G08B21/0446 , G08B25/016 , G16H10/20 , G16H20/00 , G16H50/20
摘要： A system and method that use a personal emergency response system (PERS) for fall detection and improving mobility is disclosed. The system and method for fall detection includes a PERS that has movement sensors incorporated therein configured to generate movement profiles of a user. A control system receives a movement profile from a movement sensor, compares a movement profile to a fall detection threshold indicative of a fall-down motion, and provides to the PERS, a notification prompting the user to activate an emergency contact function upon detecting that the movement profile met the fall detection threshold. The system and method for improving mobility includes a database storing user gait information and a control system configured to generate a mobility score of the user based on the gait information. Based on the mobility score of the user, the control system transmits a mobility improvement program to a device of the user.
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5.发明公开公开(公告)号：US20240226089A1
公开(公告)日：2024-07-11
申请号：US18095384
申请日：2023-01-10
IPC分类号： A61K31/472 , A61K31/4178 , A61K31/4184 , A61K31/437 , A61P1/18 , A61P35/00
CPC分类号： A61K31/472 , A61K31/4178 , A61K31/4184 , A61K31/437 , A61P1/18 , A61P35/00
摘要： Embodiments provide for methods of treatment for subjects suffering from a condition/disorder or disease for which the renin-angiotensin-aldosterone system (RAAS) plays at least some role. In one example, a method comprises administering to the subject an effective amount of one or more of an angiotensin receptor AT2R antagonist for a duration sufficient to elicit a desired response in the subject suffering from pancreatic cancer. The administering acts to reduce proliferation of tumor cells associated with the pancreatic cancer.
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公开(公告)号：US10760131B2
公开(公告)日：2020-09-01
申请号：US15553135
申请日：2016-02-23
IPC分类号： C12Q1/6883 , C12Q1/6813 , C12Q1/6874
摘要： Disclosed are methods of, and assay and kits for, detecting and diagnosing arterial plaque rupture using the expression of miR-222, mi-221 and circ284. Also disclosed are methods of treating arterial plaque rupture and methods of identifying agents for use thin the treatment of arterial plaque rupture.
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公开(公告)号：US20190135890A1
公开(公告)日：2019-05-09
申请号：US16249540
申请日：2019-01-16
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , OCHSNER CLINIC FOUNDATION , NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
IPC分类号： C07K14/635 , A61K9/00 , C12N9/10 , C12N9/64 , C12N9/50 , A61K35/28 , A61K38/16 , A61K8/64 , A61K8/66 , A61K38/48 , A61K38/29 , A61Q7/00 , C12N9/52
CPC分类号： C07K14/635 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K35/28 , A61K38/164 , A61K38/29 , A61K38/4886 , A61K2800/86 , A61K2800/91 , A61Q7/00 , C07K2319/00 , C07K2319/50 , C07K2319/70 , C12N9/1088 , C12N9/50 , C12N9/52 , C12N9/6489 , C12Y205/01018 , C12Y304/24003 , C12Y304/24007
摘要： Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.
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