METHODS OF TREATING GENERALIZED PUSTULAR PSORIASIS (GPP) USING IL-17 ANTAGONISTS
    1.
    发明申请
    METHODS OF TREATING GENERALIZED PUSTULAR PSORIASIS (GPP) USING IL-17 ANTAGONISTS 审中-公开
    使用IL-17拮抗剂治疗一般化胶原蛋白(GPP)的方法

    公开(公告)号:US20160193333A1

    公开(公告)日:2016-07-07

    申请号:US14911387

    申请日:2014-08-13

    摘要: The disclosure is directed to methods, treatment regimens, uses, kits and therapies for treating Generalized Pustular Psoriasis (GPP). These methods, treatment regimens, uses, kits and therapies utilize, inter alia, administration of an IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab. Additionally disclosed are improved methods for treating plaque-type psoriasis that utilize up-titration and down-titration of the IL-17 antagonist, e.g., an IL-17 antibody, such as secukinumab, as well as modification of dose frequency. Further disclosed are methods of treating palmoplantar pustular psoriasis using the disclosed IL-17 antagonists, e.g., IL-17 antibodies, such as secukinumab.

    摘要翻译: 本公开涉及用于治疗广泛性脓疱性银屑病(GPP)的方法,治疗方案,用途,试剂盒和治疗方法。 这些方法,治疗方案,用途,试剂盒和治疗方法尤其利用IL-17拮抗剂(例如IL-17抗体,例如塞苏单抗)的施用。 另外公开了用于治疗斑块型银屑病的改进方法,其利用IL-17拮抗剂(例如IL-17抗体例如塞苏单抗)的上滴定和下调,以及剂量频率的修改。 进一步公开的是使用所公开的IL-17拮抗剂,例如IL-17抗体(例如塞苏单抗)治疗掌跖脓疱性牛皮癣的方法。

    Sequentially configurable programmable integrated circuit
    3.
    发明授权
    Sequentially configurable programmable integrated circuit 有权
    可连续配置的可编程集成电路

    公开(公告)号:US07932743B1

    公开(公告)日:2011-04-26

    申请号:US12699703

    申请日:2010-02-03

    IPC分类号: H03K19/173 H01L25/00

    摘要: A programmable integrated circuit performs an initial partial configuration of the programmable integrated circuit in response to receiving an activation signal. In this way, the programmable integrated circuit enables an initial functionality of the programmable integrated circuit. The programmable integrated circuit then performs a subsequent partial configuration of the programmable integrated circuit for enabling additional functionality of the programmable integrated circuit. In some embodiments, the programmable integrated circuit receives an input signal indicating a stimulus in an environment of the programmable integrated circuit and determines based on the input signal whether to perform the subsequent partial configuration of the programmable integrated circuit or generate a power down signal for powering down the programmable integrated circuit without performing the subsequent partial configuration. In some embodiments, the programmable integrated circuit performs a sequence of partial subsequent configurations for enabling a sequence of additional functionalities of the programmable integrated circuit.

    摘要翻译: 可编程集成电路响应于接收到激活信号而执行可编程集成电路的初始部分配置。 以这种方式,可编程集成电路实现了可编程集成电路的初始功能。 然后,可编程集成电路执行可编程集成电路的后续部分配置,以实现可编程集成电路的附加功能。 在一些实施例中,可编程集成电路接收指示可编程集成电路的环境中的刺激的输入信号,并且基于输入信号确定是否执行可编程集成电路的后续部分配置或者产生用于供电的掉电信号 而不执行后续的部分配置。 在一些实施例中,可编程集成电路执行一系列部分后续配置,以实现可编程集成电路的附加功能序列。