公开(公告)号：US07997728B2

公开(公告)日：2011-08-16

申请号：US11743135

申请日：2007-05-01

申请人： David Huang ,  SriniVas R. Sadda ,  Ou Tan

发明人： David Huang ,  SriniVas R. Sadda ,  Ou Tan

IPC分类号： A61B3/00 ,  A61B13/00

CPC分类号： A61B3/1005 ,  A61B3/102

摘要： The present invention discloses a method for comparing the detection of clinically significant diabetic macular edema by an optical coherence tomography (OCT) grid scanning protocol and biomicroscopic examination. Also provided are computer implemented, automated systems for performing the method thereof and computer readable media encoding the method thereof.

摘要翻译： 本发明公开了一种通过光学相干断层扫描（OCT）网格扫描方案和生物显微镜检查比较临床显着性糖尿病性黄斑水肿的检测方法。 还提供了计算机实现的，用于执行其方法的自动化系统和编码其方法的计算机可读介质。

公开(公告)号：US20080309881A1

公开(公告)日：2008-12-18

申请号：US12139376

申请日：2008-06-13

申请人： David Huang ,  Ou Tan

发明人： David Huang ,  Ou Tan

IPC分类号： A61B3/10 ,  G06K9/00

CPC分类号： G06T7/0012 ,  A61B3/024 ,  A61B3/102 ,  A61B5/0066 ,  G06K2209/05 ,  G06K2209/051 ,  G06T2207/30041

摘要： Methods for analyzing retinal tomography maps to detect patterns of optic nerve diseases such as glaucoma, optic neuritis, anterior ischemic optic neuropathy are disclosed in this invention. The areas of mapping include the macula centered on the fovea, and the region centered on the optic nerve head. The retinal layers that are analyzed include the nerve fiber, ganglion cell, inner plexiform and inner nuclear layers and their combinations. The overall retinal thickness can also be analyzed. Pattern analysis are applied to the maps to create single parameter for diagnosis and progression analysis of glaucoma and optic neuropathy.

摘要翻译： 用于分析视网膜断层摄影图的方法用于检测视神经疾病如青光眼，视神经炎，前部缺血性视神经病变的模式在本发明中公开。 映射区域包括以中心凹为中心的黄斑，以视神经头为中心的区域。 分析的视网膜层包括神经纤维，神经节细胞，内丛状和内核层及其组合。 也可以分析整个视网膜厚度。 模式分析应用于地图，为青光眼和视神经病变的诊断和进展分析创建单一参数。

公开(公告)号：US09655512B2

公开(公告)日：2017-05-23

申请号：US13441733

申请日：2012-04-06

申请人： David Huang ,  Yan Li ,  Ou Tan ,  Maolong Tang

发明人： David Huang ,  Yan Li ,  Ou Tan ,  Maolong Tang

IPC分类号： A61B3/107 ,  A61B3/10 ,  G06T7/60

CPC分类号： A61B3/1005 ,  G06T7/60 ,  G06T2207/10101 ,  G06T2207/30041

摘要： This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as well as parameters useful for evaluating the properties. The methods and systems described herein are useful as eye disease diagnostic tools and eye surgery planning tools.

公开(公告)号：US20100277691A1

公开(公告)日：2010-11-04

申请号：US12771849

申请日：2010-04-30

申请人： David HUANG ,  Ake Lu ,  Ou Tan

发明人： David HUANG ,  Ake Lu ,  Ou Tan

IPC分类号： A61B3/14

CPC分类号： G06T7/0012 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/30041

摘要： This invention discloses methods and systems for diagnosing glaucoma by combining diagnostic parameters derived from optical coherence tomography images of three different anatomic regions of the eye, including the macular ganglion cell complex (mGCC), the peripapillary nerve fiber layer (ppNFL), and the optic nerve head (ONH). The combined diagnostic parameters form a reduced set of global parameters, which are then fed to pre-trained machine classifiers as input to arrive at a single diagnostic indicator for glaucoma. Also disclosed are methods for training a machine classifier to be used in methods and systems of this invention.

摘要翻译： 本发明公开了通过组合来自眼睛三个不同解剖区域的光学相干断层摄影图像的诊断参数来诊断青光眼的方法和系统，包括黄斑神经节细胞复合物（mGCC），周围神经纤维层（ppNFL）和视神经纤维 神经头（ONH）。 组合的诊断参数形成一组减少的全局参数，然后将其输入预训练的机器分类器作为输入，以得到青光眼的单一诊断指标。 还公开了用于训练在本发明的方法和系统中使用的机器分类器的方法。

公开(公告)号：US07905599B2

公开(公告)日：2011-03-15

申请号：US12771849

申请日：2010-04-30

申请人： David Huang ,  Ake Lu ,  Ou Tan

发明人： David Huang ,  Ake Lu ,  Ou Tan

IPC分类号： A61B3/00

CPC分类号： G06T7/0012 ,  G06T2207/10101 ,  G06T2207/20081 ,  G06T2207/30041

摘要： This invention discloses methods and systems for diagnosing glaucoma by combining diagnostic parameters derived from optical coherence tomography images of three different anatomic regions of the eye, including the macular ganglion cell complex (mGCC), the peripapillary nerve fiber layer (ppNFL), and the optic nerve head (ONH). The combined diagnostic parameters form a reduced set of global parameters, which are then fed to pre-trained machine classifiers as input to arrive at a single diagnostic indicator for glaucoma. Also disclosed are methods for training a machine classifier to be used in methods and systems of this invention.

摘要翻译： 本发明公开了通过组合来自眼睛三个不同解剖区域的光学相干断层摄影图像的诊断参数来诊断青光眼的方法和系统，包括黄斑神经节细胞复合物（mGCC），周围神经纤维层（ppNFL）和视神经纤维 神经头（ONH）。 组合的诊断参数形成一组减少的全局参数，然后将其输入预训练的机器分类器作为输入，以得到青光眼的单一诊断指标。 还公开了用于训练在本发明的方法和系统中使用的机器分类器的方法。

公开(公告)号：US20070287932A1

公开(公告)日：2007-12-13

申请号：US11743135

申请日：2007-05-01

申请人： David Huang ,  SriniVas Sadda ,  Ou Tan

发明人： David Huang ,  SriniVas Sadda ,  Ou Tan

IPC分类号： A61B3/10

CPC分类号： A61B3/1005 ,  A61B3/102

摘要： The present invention discloses a method for comparing the detection of clinically significant diabetic macular edema by an optical coherence tomography (OCT) grid scanning protocol and biomicroscopic examination. Also provided are computer implemented, automated systems for performing the method thereof and computer readable media encoding the method thereof.

摘要翻译： 本发明公开了一种通过光学相干断层扫描（OCT）网格扫描方案和生物显微镜检查比较临床显着性糖尿病性黄斑水肿的检测方法。 还提供了计算机实现的，用于执行其方法的自动化系统和编码其方法的计算机可读介质。

公开(公告)号：US07347548B2

公开(公告)日：2008-03-25

申请号：US10833524

申请日：2004-04-28

申请人： David Huang ,  Ou Tan ,  Yan Li

发明人： David Huang ,  Ou Tan ,  Yan Li

IPC分类号： A61B3/10

CPC分类号： A61B3/102

摘要： Methods and systems are provided for measuring a retinal sublayer characteristic of an eye. A plurality of axial scans are performed over an area of the retina of the eye. Reflections are measured during the axial scans to determine a plurality of sets of reflection intensity values. A given set of reflection intensity values is associated with one of the plurality of axial scans. A progressive refinement boundary detection algorithm is performed using the plurality of sets of reflection intensity values to determine at least one boundary location associated with the retinal sublayer for each of the plurality of sets of reflection intensity values. The retinal sublayer characteristic is determined in response to the determined boundary locations.

摘要翻译： 提供了用于测量眼睛的视网膜亚层特征的方法和系统。 在眼睛的视网膜的一个区域上执行多个轴向扫描。 在轴向扫描期间测量反射以确定多组反射强度值。 给定的一组反射强度值与多个轴向扫描中的一个相关联。 使用多组反射强度值执行逐行细化边界检测算法，以针对多组反射强度值中的每一组来确定与视网膜子层相关联的至少一个边界位置。 响应于确定的边界位置来确定视网膜亚层特征。

公开(公告)号：US20050018133A1

公开(公告)日：2005-01-27

申请号：US10833524

申请日：2004-04-28

申请人： David Huang ,  Ou Tan ,  Yan Li

发明人： David Huang ,  Ou Tan ,  Yan Li

IPC分类号： A61B3/10 ,  A61B3/12 ,  G01B9/02

CPC分类号： A61B3/102

摘要： Methods and systems are provided for measuring a retinal sublayer characteristic of an eye. A plurality of axial scans are performed over an area of the retina of the eye. Reflections are measured during the axial scans to determine a plurality of sets of reflection intensity values. A given set of reflection intensity values is associated with one of the plurality of axial scans. A progressive refinement boundary detection algorithm is performed using the plurality of sets of reflection intensity values to determine at least one boundary location associated with the retinal sublayer for each of the plurality of sets of reflection intensity values. The retinal sublayer characteristic is determined in response to the determined boundary locations.

摘要翻译： 提供了用于测量眼睛的视网膜亚层特征的方法和系统。 在眼睛的视网膜的一个区域上执行多个轴向扫描。 在轴向扫描期间测量反射以确定多组反射强度值。 给定的一组反射强度值与多个轴向扫描中的一个相关联。 使用多组反射强度值执行逐行细化边界检测算法，以针对多组反射强度值中的每一组来确定与视网膜子层相关联的至少一个边界位置。 响应于确定的边界位置来确定视网膜亚层特征。

公开(公告)号：US09918630B2

公开(公告)日：2018-03-20

申请号：US15253597

申请日：2016-08-31

申请人： Ou Tan ,  David Huang

发明人： Ou Tan ,  David Huang

IPC分类号： A61B3/12 ,  A61B3/00 ,  A61B3/10

CPC分类号： A61B3/1225 ,  A61B3/0025 ,  A61B3/102 ,  G06T7/136 ,  G06T2207/30041

摘要： A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

公开(公告)号：US20170055829A1

公开(公告)日：2017-03-02

申请号：US15253597

申请日：2016-08-31

申请人： Ou Tan ,  David Huang

发明人： Ou Tan ,  David Huang

IPC分类号： A61B3/12 ,  A61B3/10 ,  A61B3/00

CPC分类号： A61B3/1225 ,  A61B3/0025 ,  A61B3/102 ,  G06T7/136 ,  G06T2207/30041

摘要： A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

摘要翻译： 公开了一种基于从光学相干断层摄影（OCT）图像数据获得的内部限制膜（ILM）的空间频率分析来检测受试者中的青光眼的方法。 基于所分析的ILM谱的空间频率含量，计算称为视网膜表面轮廓变异性（RSCV）的量，并且基于RSCV幅度确定青光眼状况的存在或不存在。