公开(公告)号：US09655512B2

公开(公告)日：2017-05-23

申请号：US13441733

申请日：2012-04-06

申请人： David Huang ,  Yan Li ,  Ou Tan ,  Maolong Tang

发明人： David Huang ,  Yan Li ,  Ou Tan ,  Maolong Tang

IPC分类号： A61B3/107 ,  A61B3/10 ,  G06T7/60

CPC分类号： A61B3/1005 ,  G06T7/60 ,  G06T2207/10101 ,  G06T2207/30041

摘要： This invention discloses methods and systems for measuring corneal epithelial thickness and power, stromal thickness, subepitheila corneal power and topography. The systems and methods disclosed herein are non-invasive, non-contact and automated imaging methods which preferably makes use of Fourier-domain optical tomography. Also disclosed herein are scanning patterns and image analysis methods for utilizing and analyzing Fourier-domain optical coherence tomography images to obtain information about conical epithelial and stromal properties as well as parameters useful for evaluating the properties. The methods and systems described herein are useful as eye disease diagnostic tools and eye surgery planning tools.

公开(公告)号：US20070282313A1

公开(公告)日：2007-12-06

申请号：US11757195

申请日：2007-06-01

申请人： David Huang ,  Jonathan Song ,  Yan Li ,  Maolong Tang

发明人： David Huang ,  Jonathan Song ,  Yan Li ,  Maolong Tang

IPC分类号： A61B18/18

CPC分类号： A61B3/1005 ,  A61B3/102 ,  A61F9/00804 ,  A61F9/00831 ,  A61F2009/00851 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882

摘要： Optical coherence tomography (OCT) is used to map the surface elevation and thickness of the cornea. The OCT maps are used to plan laser procedures for the treatment of an irregular, opacified or weakened cornea, and in the treatment of refractive errors. In the excimer laser phototherapeutic keratectomy (PTK) procedure, the OCT data is used to plan a map of ablation depth needed to restore a smooth optical surface. In the excimer laser photorefractive keratectomy procedure, OCT mapping of epithelial thickness is used to achieve clean laser epithelial removal. In femtosecond laser anterior keratoplasty procedure, OCT data is used to plan the depth of femtosecond laser dissection to remove an anterior layer of the cornea, leaving a smooth recipient bed of uniform thickness to receive a disk of donated corneal tissue. The linkage of an OCT system to a precise laser surgical system enables the performance of new procedures that are safer, less invasive and produce faster visual recovery than conventional surgical procedures.

摘要翻译： 光学相干断层扫描（OCT）用于绘制角膜的表面高程和厚度。 OCT图用于计划用于治疗不规则，不透明或弱化的角膜的激光程序，以及治疗屈光不正。 在准分子激光治疗性角膜切除术（PTK）中，OCT数据用于计划恢复光滑表面所需的消融深度图。 在准分子激光屈光角膜切除手术中，使用上皮厚度的OCT图来实现清洁的激光上皮移除。 在飞秒激光前角膜移植术中，OCT数据用于计划飞秒激光解剖深度以去除角膜前壁，留下均匀厚度的平滑受体床，以接收捐赠的角膜组织盘。 OCT系统与精确的激光手术系统的联系使得能够执行比常规外科手术更安全，更少侵入性并且产生更快的视觉恢复的新程序。

公开(公告)号：US20070291228A1

公开(公告)日：2007-12-20

申请号：US11743136

申请日：2007-05-01

申请人： David Huang ,  Maolong Tang

发明人： David Huang ,  Maolong Tang

IPC分类号： A61B3/107 ,  G06F17/10

CPC分类号： A61B3/107

摘要： The present invention discloses a method for characterizing ectatic diseases of the cornea by computing a mean curvature map of the anterior or posterior surfaces of the cornea and fitting the map to a Gaussian function to characterize the surface features of the map. Exemplary ectatic disease that may be characterized include keratoconus and pellucid marginal degeneration. Also disclosed are a system for diagnosing ectatic disease of the cornea and a computer readable medium encoding the method thereof.

摘要翻译： 本发明公开了一种用于通过计算角膜前表面或后表面的平均曲率图并将该贴图拟合为高斯函数来表征地图的表面特征的方法来表征角膜的异位疾病。 可以表征的示例性外周疾病包括圆锥角膜和透明边缘变性。 还公开了用于诊断角膜的角膜疾病的系统和编码其角膜的计算机可读介质。

公开(公告)号：US07497575B2

公开(公告)日：2009-03-03

申请号：US11743136

申请日：2007-05-01

申请人： David Huang ,  Maolong Tang

发明人： David Huang ,  Maolong Tang

IPC分类号： A61B3/14 ,  A61B3/10

CPC分类号： A61B3/107

摘要： The present invention discloses a method for characterizing ectatic diseases of the cornea by computing a mean curvature map of the anterior or posterior surfaces of the cornea and fitting the map to a Gaussian function to characterize the surface features of the map. Exemplary ectatic disease that may be characterized include keratoconus and pellucid marginal degeneration. Also disclosed are a system for diagnosing ectatic disease of the cornea and a computer readable medium encoding the method thereof.

摘要翻译： 本发明公开了一种用于通过计算角膜前表面或后表面的平均曲率图并将该贴图拟合为高斯函数来表征地图的表面特征的方法来表征角膜的异位疾病。 可以表征的示例性外周疾病包括圆锥角膜和透明边缘变性。 还公开了用于诊断角膜的角膜疾病的系统和编码其角膜的计算机可读介质。

公开(公告)号：US20050107775A1

公开(公告)日：2005-05-19

申请号：US10506842

申请日：2003-02-28

申请人： David Huang ,  Raj Shekhar ,  Maolong Tang

发明人： David Huang ,  Raj Shekhar ,  Maolong Tang

IPC分类号： A61F9/008 ,  A61F9/01 ,  G02B26/08 ,  A61B18/20

CPC分类号： A61F9/008 ,  A61F9/00806 ,  A61F2009/00842 ,  A61F2009/00844 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00897 ,  G02B26/0816

摘要： The present invention relates to laser ablation patterns to correct refractive errors of the eye (60) such as nearsightedness, farsightedness, astigmatism, and higher order aberrations of the eye (60). The laser ablation patterns used to control the laser (10) prevent induced aberrations by compensating for post-procedure epithelial smoothing. The position of laser pulses (12) is also controlled to optimize the achievement of the intended ablation pattern.

摘要翻译： 本发明涉及用于校正眼睛（60）的屈光不正的激光烧蚀图案，例如眼睛（60）的近视，远视，像散和高阶像差。 用于控制激光（10）的激光烧蚀图案通过补偿手术后上皮平滑来防止诱发的像差。 还控制激光脉冲（12）的位置以优化预期消融模式的实现。