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公开(公告)号：US20180059103A1
公开(公告)日：2018-03-01
申请号：US15797502
申请日：2017-10-30
发明人： SANJEEV SAXENA , LOUIS EUGENE BURTON , FRANCIS WILLIAM LAU , ANDREA CUPPOLETTI , RAJINDER KAUR BHATIA
IPC分类号： G01N33/543 , B01L3/00 , G01N33/574
CPC分类号： G01N33/54366 , B01L3/50273 , B01L3/502761 , B01L2200/0668 , B01L2300/0627 , B01L2300/0803 , B01L2300/0864 , B01L2400/0409 , G01N33/54313 , G01N33/574 , G01N33/57415
摘要： Devices for detecting biomarkers in a sample and methods for detecting such biomarkers are discussed. The biomarkers may be associated with a particular disease such as breast cancer or another health condition. The devices may contain a disc including a plurality of microfluidic channels extending in a radial direction of the disc, the microfluidic channels pre-loaded with a plurality of capture molecules specific to at least one biomarker. The methods may include introducing a fluid sample into at least one microfluidic channel of a disc, rotating the disc, such that the fluid sample flows radially outward through the at least one microfluidic channel to combine with capture molecules specific to at least one biomarker, and detecting a signal from the disc indicative of a presence of the at least one biomarker contained in the fluid sample.
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公开(公告)号：US20180161772A1
公开(公告)日：2018-06-14
申请号：US15881792
申请日：2018-01-28
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/0605 , B01L2300/0803 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0622 , G01N33/54313 , G01N33/54366
摘要： Aspects of the present disclosure are drawn to microfluidic devices. An exemplary microfluidic device may include a disc having at least one microfluidic channel pathway extending radially outward from a center of the disc. The channel pathway may include an inlet for receiving a sample, a first chamber fluidly connected to the inlet, and a second chamber positioned radially inward relative to and fluidly connected to the first chamber. The channel pathway may also include at least one third chamber positioned radially outward of the second chamber and fluidly connected to the second chamber via an outlet channel The channel pathway may include at least one fourth chamber fluidly connected to the at least one third chamber and positioned radially outward of the at least one third chamber. At least one of the first, second, third, or fourth chambers may contain at least one reagent pre-loaded into the disc.
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公开(公告)号：US20190070609A1
公开(公告)日：2019-03-07
申请号：US16180224
申请日：2018-11-05
IPC分类号： B01L3/00 , G01N33/538 , G01N33/543 , G01N33/574 , G01N33/00 , G01N33/533
摘要： Devices for detecting biomarkers in a sample and methods for detecting such biomarkers are discussed. The biomarkers may be associated with a particular disease such as cancer or another health condition. The devices may contain a disc including a plurality of microfluidic channels extending in a radial direction of the disc, the microfluidic channels pre-loaded with a plurality of capture molecules specific to at least one biomarker. The methods may include introducing a fluid sample into at least one microfluidic channel of a disc, rotating the disc, such that the fluid sample flows radially outward through the at least one microfluidic channel to combine with capture molecules specific to at least one biomarker, and detecting a signal from the disc indicative of a presence of the at least one biomarker contained in the fluid sample.
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公开(公告)号：US20180135110A1
公开(公告)日：2018-05-17
申请号：US15832635
申请日：2017-12-05
IPC分类号： C12Q1/6811 , C12Q1/6806 , C12Q1/686
CPC分类号： C12Q1/6811 , B01L3/5027 , C12N2310/16 , C12N2310/3519 , C12Q1/6806 , C12Q1/6834 , C12Q1/686 , C12Q2600/158 , G01N33/54366 , C12Q2523/32 , C12Q2525/205 , C12Q2565/625 , C12Q2565/629
摘要： Devices for detecting targets in a sample and methods for detecting such targets are discussed. The targets may be biomarkers associated with a disease or other health condition. The devices may contain a disc including a plurality of microfluidic channels each extending in a radial direction of the disc, the microfluidic channels containing a plurality of capture molecules specific to at least one target. The capture molecules may include an aptamer and/or an oligonucleotide capable of hybridizing to the target. The methods may include introducing a fluid sample into one or more microfluidic channels of a disc, rotating the disc, such that the fluid sample flows radially outward through the microfluidic channel(s) to combine with capture molecules in the disc, and detecting a signal from the disc indicative of a presence of the target.
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